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Whole-Brain RT Recommended for Patients with Brain Metastases

By MedImaging International staff writers
Posted on 10 Oct 2019
A new study shows that patients with brain metastases who received whole-brain radiotherapy (RT) experience fewer neurologic symptoms and better cognition over time when hippocampal neural stem cells are protected.

Researchers at Northwestern Medicine (NM; Winfield, IL, USA) and the Mayo Clinic (Rochester, MN, USA) conducted a study in 518 patients in order to examine the hypothesis that radiation to the hippocampal stem cells plays a role in cognitive decline. To do so, study participants were randomized to whole brain RT plus memantine (a NMDA antagonist used to improve cognition, mood, behavior, and the ability to perform daily activities in moderate to severe Alzheimer's disease), with or without hippocampal avoidance.

The researchers found a 26% relative reduction in risk of cognitive toxicity following whole brain RT with hippocampal avoidance, compared to whole-brain RT. Patients who received treatment that avoided the hippocampus continued to maintain measurable improvements in cognition, with fewer neurologic symptoms, less interference of neurologic symptoms in their daily activities, and less memory problems. Toxicity, intracranial progression-free survival, and overall survival outcomes were similar to those experienced by patients who had whole-brain RT. The study was presented at the American Society for Radiation Oncology annual meeting, held during September 2019 in Chicago (IL, USA).

“These results revolutionize our understanding of the cognitive effects of brain irradiation in a manner that has far-reaching implications in terms of the safer radiotherapy treatment of primary or metastatic brain tumors,” said lead author and study presenter Vinai Gondi, MD, director of research at the NM Proton Center. “Our phase III trial not only provides evidence for practice change in the management of brain metastases, but also builds upon decades of preclinical and clinical research to definitely establish the hippocampus as a radiosensitive and cognition-specific organ at risk during brain irradiation.”

The hippocampus (part of the Limbic system) is a small formation in the temporal lobe responsible for the processing of long-term memory and emotional responses. Certain sub-regions of the hippocampus play roles in different types of memory, such as spatial memories, emotional behavior, and regulation of hypothalamic functions. The hippocampus is one of the unique regions in brain where the neurogenesis continues even in adult life, thanks to neural stem cells that integrate into the mainstream neurons.

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102 (215.05355834961): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (!!!!! 6172.8954315186): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
105 (!!!!! 8736.1335754395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
106 (!!!!! 3726.9592285156): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779631 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (932.93190002441): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779631 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (818.01414489746): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
109 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
110 (77.009201049805): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294779631 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (!!!!! 3015.9950256348): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294779631 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (957.96585083008): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (524.04403686523): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (336.1701965332): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
115 (374.07875061035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
116 (600.09956359863): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
117 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
118 (874.99618530273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
119 (269.88983154297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
120 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
121 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
122 (224.11346435547): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
123 (!!!!! 59267.044067383): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
124 (!!!!! 4305.1242828369): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779631 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779631 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (!!!!! 19907.95135498): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (!!!!! 3606.0810089111): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (649.92904663086): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
128 (272.98927307129): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (!!!!! 4356.861114502): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
130 (!!!!! 5589.9620056152): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (!!!!! 2264.0228271484): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
132 (87.976455688477): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (284.91020202637): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
134 (45.7763671875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (!!!!! 2510.0708007812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
136 (!!!!! 3199.1004943848): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (193.11904907227): SELECT name FROM jos_deeppockets WHERE id=213
138 (41.961669921875): SELECT name FROM jos_deeppockets WHERE id=213
139 (689.02969360352): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
140 (571.96617126465): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (114.91775512695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
142 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
143 (!!!!! 13458.013534546): TRUNCATE TABLE jos_trademed_module
144 (!!!!! 1737.117767334): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779631 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
145 (102.99682617188): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779631 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (575.06561279297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (931.0245513916): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
149 (83.208084106445): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
150 (!!!!! 1765.0127410889): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
151 (!!!!! 4494.9054718018): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
152 (195.02639770508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
153 (921.01097106934): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779631 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779631 AND type='deeppockets_item' AND published='1' LIMIT 1
154 (101.08947753906): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)
155 (318.05038452148): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)
156 (41.961669921875): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
157 (488.9965057373): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
158 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779631 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779631 AND published='1' LIMIT 1
159 (413.89465332031): select jos_twitters.link from jos_twitters where cat=10
160 (40.054321289062): select jos_facebook.link from jos_facebook where cat=10
161 (36.001205444336): select jos_google_plus.link from jos_google_plus where cat=10
162 (72.002410888672): select jos_linkedin.link from jos_linkedin where cat=10