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Anchored Beacon Transponder Guides Lung Cancer Radiotherapy

By MedImaging International staff writers
Posted on 01 May 2018

Image: The Calypso anchored beacon transponder (Photo courtesy of Varian Medical Systems).

A novel beacon transponder detects even slight movements of a tumor, helping clinicians deliver lung stereotactic body radiotherapy (SBRT) more precisely.

The Varian Medical Systems (Varian; Palo Alto, CA, USA) Calypso Anchored Beacon Transponder is designed for implantation in small airways within or near the tumor target. Anchoring is provides via five expandable nitinol legs that provide stable fixation, preventing the transponder from moving. Once in place, the transponder emits continuous, non-ionizing electromagnetic signals that are tracked in real-time and used to keep a SBRT beam on target. The Anchored Beacon transponder is intended for use with the Varian TrueBeam, Edge, and Clinac C-series medical linear accelerators.

The direct internal tracking eliminates the need for external surrogates to track tumor motion in real time, so that high-dose lung SBRT can be delivered with reduced margins between the clinical target volume (CTV) and the planning target volume (PTV). The implantation process itself is straightforward, similar to a lung biopsy, using a pre-loaded, single use delivery catheter designed for interventional pulmonologists and general pulmonologists with advanced bronchoscopy training. The Calypso Anchored Beacon Transponder has been approved by the U.S. Food and Drug Administration (FDA).

“The 510(k) clearance of the Anchored Beacon Transponder expands the application of the Calypso system platform,” said Ed Vertatschitsch, vice president of global portfolio solutions at Varian. “Using the Calypso system and Anchored Beacon transponder, clinicians can deliver dose to lung tumors with increased confidence and accuracy.”

SBRT is emerging as an attractive option for treating cancers in the lung, head and neck, prostate, liver and other disease sites, with the objective of increasing local control of the target lesion while limiting damage to nearby critical structures and normal tissue. Requirements include precise localization of the target lesion in the treatment planning process; accounting for tumor motion due to respiration or other changes in the body; highly conformal dose distribution to the target volume, including a steep dose gradient to minimize radiation to surrounding healthy tissue; and image-guidance at the time of dose delivery for verification and adjustment of the target localization.

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66 (62.942504882812): select jos_google_plus.link from jos_google_plus where cat=10

67 (48.87580871582): select jos_linkedin.link from jos_linkedin where cat=10

68 (!!!!! 4846.0960388184): SELECT fid FROM jos_deeppockets WHERE id=294773360 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294773360 AND published='1' LIMIT 1

69 (127.07710266113): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (450.13427734375): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294773360 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (366.2109375): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294773360 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (70.810317993164): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (396.0132598877): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (236.03439331055): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (113.96408081055): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (87.02278137207): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (59.843063354492): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (82.969665527344): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (102.99682617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (82.015991210938): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (84.161758422852): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (394.10591125488): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294773360 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (95.129013061523): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294773360 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (44.107437133789): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (549.0779876709): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 4229.0687561035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

105 (142.81272888184): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

106 (67.949295043945): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294773360 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294773360 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

109 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

110 (63.896179199219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294773360 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (549.0779876709): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294773360 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (638.96179199219): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (379.08554077148): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

115 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

116 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

117 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

118 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

119 (34.093856811523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

120 (49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

121 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

122 (526.90505981445): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294773360 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294773360 AND type='deeppockets_item' AND published='1' LIMIT 1

123 (!!!!! 2312212.9440308): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

124 (443.93539428711): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

125 (!!!!! 3594.1600799561): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

126 (305.8910369873): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

127 (454.90264892578): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

128 (85.830688476562): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

129 (108.95729064941): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

130 (80.82389831543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

131 (608.92105102539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

132 (850.20065307617): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

133 (50.067901611328): SELECT name FROM jos_deeppockets WHERE id=213

134 (36.001205444336): SELECT name FROM jos_deeppockets WHERE id=213

135 (820.15991210938): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

136 (405.78842163086): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

137 (!!!!! 2800.9414672852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

138 (!!!!! 3147.1252441406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

139 (461.10153198242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

142 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

143 (!!!!! 1223.087310791): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

144 (210.04676818848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

145 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

146 (56.028366088867): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294773360 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294773360 AND type='deeppockets_item' AND published='1' LIMIT 1

147 (103.95050048828): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

148 (95.129013061523): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

149 (!!!!! 4356.1458587646): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

150 (!!!!! 3192.9016113281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

151 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773360 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773360 AND published='1' LIMIT 1

152 (42.200088500977): select jos_twitters.link from jos_twitters where cat=10

153 (25.98762512207): select jos_facebook.link from jos_facebook where cat=10

154 (25.98762512207): select jos_google_plus.link from jos_google_plus where cat=10

155 (25.98762512207): select jos_linkedin.link from jos_linkedin where cat=10

156 (562.90626525879): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

157 (!!!!! 9560.8234405518): insert into jos_banners_delta values (14615,'2025-04-30 13:55:25','3.136.159.203','view'),(14202,'2025-04-30 13:55:25','3.136.159.203','view'),(14203,'2025-04-30 13:55:25','3.136.159.203','view')

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