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PET Scan May Help Personalize Cancer Treatment

By MedImaging International staff writers
Posted on 14 Mar 2018

Image: PET images of kidneys and spleen 90 minutes post injection of 18F-BMS-986192 and anti-PD-L1 immunohistochemistry of healthy monkey spleen tissue (R) (Photo courtesy of David Donnelly/ BMS).

A same-day, noninvasive positron emission tomography (PET)-based imaging approach could help guide cancer treatment decisions and assess treatment response, claims a new study.

Researchers at Bristol-Myers Squibb (BMS; Princeton, NJ, USA) have developed a fluorine-18 (18F)-labeled engineered protein that targets the programmed death protein (PD-1), and its ligand PD-L1, which enables cancer to evade the immune system. The PD-L1 radioligand (18F-BMS-986192) was then evaluated in mice bearing bilateral PD-L1(-) and PD-L1(+) subcutaneous tumors in human tissues, as well as evaluating distribution, binding and radiation dosimetry in healthy cynomolgus monkey.

The results revealed that 18F-BMS-986192 bound to human and cynomolgus PD-L1 tumor tissues as a function of PD-L1 expression, with radioligand binding blocked in a dose-dependent manner. In-vivo PET imaging clearly visualized PD-L1 expression in the mice implanted with PD-L1(+) xenograft tumors. Two hours after dosing, a 3.5-fold-higher uptake was observed in the implanted mice, compared to control mice with PD-L1(–) tumors. Co-administration of an anti–PD-L1 adnectin reduced tumor uptake at two hours after injection by approximately 70%, demonstrating PD-L1–specific binding.

Biodistribution in the cynomolgus monkey showed binding in the spleen, which is rich in the PD-L1, with rapid blood clearance through the kidneys and bladder. Binding in the PD-L1(+) spleen was also reduced by co-administration of 18F-BMS-986192. According to the researchers, the results demonstrate the feasibility of the approach, and that radiation dosimetry estimates indicate that the tracer is safe to administer in human studies. The study was published in the March 2018 issue of The Journal of Nuclear Medicine.

“This approach represents an opportunity for physicians to noninvasively assess all of a patient's tumors for PD-L1 expression with a single PET scan and timely readout,” said lead author David Donnelly, PhD, of BMS Pharmaceutical Research and Development. “This may help guide treatment decisions and assess treatment response, to help identify the right treatment for the right patient at the right time and right dose.”

The PD-1 pathway is a cell surface receptor that plays an important role in down-regulating the immune system and promoting self-tolerance by suppressing T-cell inflammatory activity. The pathway guards against autoimmunity through a dual mechanism of promoting apoptosis in lymph node antigen-specific T-cells, while simultaneously reducing apoptosis in regulatory T-cells. Through these mechanisms, PD-1 inhibits the immune system, preventing autoimmune diseases, but it can also prevent the immune system from killing cancer cells.

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66 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

67 (28.848648071289): select jos_linkedin.link from jos_linkedin where cat=10

68 (31.948089599609): SELECT fid FROM jos_deeppockets WHERE id=294772835 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294772835 AND published='1' LIMIT 1

69 (36.954879760742): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (258.9225769043): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294772835 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (205.03997802734): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294772835 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 13813.972473145): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 3927.9460906982): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294772835 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (47.922134399414): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294772835 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (36.001205444336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (468.96934509277): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (485.89706420898): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (221.01402282715): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (432.01446533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

105 (175.95291137695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

106 (200.03318786621): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294772835 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (663.04206848145): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294772835 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 3319.9787139893): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

109 (78.201293945312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

110 (55.074691772461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294772835 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (683.06922912598): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294772835 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (574.82719421387): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 3523.8265991211): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

115 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

116 (409.12628173828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

117 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

118 (380.03921508789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

119 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

120 (425.10032653809): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 48138.856887817): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (523.80561828613): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

123 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

124 (519.0372467041): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294772835 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294772835 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 1342006.9217682): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 711351.87149048): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (247.00164794922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (201.94053649902): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (344.99168395996): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (210.04676818848): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (260.82992553711): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (197.8874206543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (!!!!! 2840.0421142578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (586.03286743164): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (357.86628723145): SELECT name FROM jos_deeppockets WHERE id=213

136 (45.061111450195): SELECT name FROM jos_deeppockets WHERE id=213

137 (690.93704223633): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (477.07557678223): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (!!!!! 1640.796661377): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

140 (441.07437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

141 (!!!!! 6088.0184173584): TRUNCATE TABLE jos_trademed_module

142 (181.91337585449): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294772835 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (!!!!! 1178.9798736572): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294772835 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (385.99967956543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

147 (42.200088500977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

148 (!!!!! 2151.0124206543): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (144.00482177734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

150 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

151 (!!!!! 2531.0516357422): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294772835 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294772835 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (368.83354187012): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

153 (42.915344238281): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

154 (56.982040405273): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (260.1146697998): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

156 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294772835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294772835 AND published='1' LIMIT 1

157 (357.15103149414): select jos_twitters.link from jos_twitters where cat=10

158 (113.96408081055): select jos_facebook.link from jos_facebook where cat=10

159 (102.99682617188): select jos_google_plus.link from jos_google_plus where cat=10

160 (139.95170593262): select jos_linkedin.link from jos_linkedin where cat=10

161 (969.88677978516): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1250.9822845459): insert into jos_banners_delta values (14615,'2025-04-30 14:00:49','3.144.201.213','view'),(14202,'2025-04-30 14:00:49','3.144.201.213','view'),(14203,'2025-04-30 14:00:49','3.144.201.213','view')

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