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Radiotherapy Prolongs Survival of NSCLC Patients

By MedImaging International staff writers
Posted on 07 Sep 2017

Metastatic non-small-cell lung cancer (mNSCLC) patients treated with a combined chemotherapy and radiation therapy (RT) regimen can live up to one year longer, according to a new study.

Researchers at Siena University Hospital (Italy), Bianchi-Melacrino-Morelli Hospital (Reggio, Italy) and other institutions conducted a retrospective analysis of 69 patients with unresectable, inoperable mNSCLC who received the mPEBev chemotherapy regimen, composed of fractionated cisplatin, oral etoposide, and bevacizumab, a monoclonal antibody that inhibits blood vessel growth in the tumor. Of these patients, 45 were also given palliative RT treatments to one or more metastatic sites.

A statistical analysis of the study results revealed a much longer median survival period of about 10 months (with the longest survival of over two years) in the group of patients who received RT, with no difference in progression-free survival. In particular, the patients survival correlated with the mPEBev regimen ability to induce the percentage of activated dendritic cells (DCs) and central-memory- T-cells (CD3, CD8+, CD45RA-, and CCR7+). The study was published on August 24, 2017, in Oncotarget.

“We found that radiotherapy, together with its direct cytolytic effect on tumor tissue, also elicits systemic immunological events, similarly to cancer vaccines,” said study co-author Professor Luigi Pirtoli, MD, director of radiation oncology at the University of Siena. “This response may result in the regression of distant metastases, known as the abscopal effect, as suggested by immunological mechanisms further investigated by our team in previous research.”

NSCLC is the most common type of lung cancer, and include squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Other subtypes, such as adenosquamous and sarcomatoid carcinoma, are less common. Patients in early stages of NSCLC can undergo lung lobectomy, but it is not performed on patients that have lung cancer that has already metastasized to other parts of the body.

Related Links:
Siena University Hospital
Bianchi-Melacrino-Morelli Hospital

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70 (405.07316589355): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294770680 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (334.9781036377): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294770680 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (70.095062255859): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (47.206878662109): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (!!!!! 1360.8932495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (43.869018554688): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294770680 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294770680 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (66.041946411133): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (62.942504882812): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (94.175338745117): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

105 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

106 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294770680 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (523.80561828613): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294770680 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

109 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

110 (48.87580871582): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294770680 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (468.96934509277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294770680 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (795.84121704102): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (531.91184997559): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (133.99124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

115 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

116 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

117 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

118 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

119 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

120 (414.84832763672): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 60351.848602295): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (159.97886657715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

123 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

124 (575.06561279297): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294770680 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294770680 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 697192.90733337): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (97.990036010742): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (159.97886657715): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (138.99803161621): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (137.8059387207): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (106.0962677002): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (106.0962677002): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (!!!!! 1046.1807250977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (748.1575012207): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (211.95411682129): SELECT name FROM jos_deeppockets WHERE id=213

136 (43.869018554688): SELECT name FROM jos_deeppockets WHERE id=213

137 (916.95785522461): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (988.96026611328): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (808.0005645752): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

140 (221.96769714355): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

141 (!!!!! 18618.106842041): TRUNCATE TABLE jos_trademed_module

142 (161.88621520996): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294770680 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (401.02005004883): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294770680 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (552.89268493652): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (167.8466796875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (114.91775512695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

147 (184.05914306641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

148 (!!!!! 1189.9471282959): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (257.01522827148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

150 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

151 (295.87745666504): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294770680 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294770680 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (105.14259338379): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

153 (76.055526733398): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

154 (429.15344238281): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

156 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770680 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770680 AND published='1' LIMIT 1

157 (219.10667419434): select jos_twitters.link from jos_twitters where cat=10

158 (76.055526733398): select jos_facebook.link from jos_facebook where cat=10

159 (74.863433837891): select jos_google_plus.link from jos_google_plus where cat=10

160 (76.055526733398): select jos_linkedin.link from jos_linkedin where cat=10

161 (684.02290344238): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1693.0103302002): insert into jos_banners_delta values (14615,'2025-04-30 13:41:47','3.137.136.226','view'),(14202,'2025-04-30 13:41:47','3.137.136.226','view'),(14203,'2025-04-30 13:41:47','3.137.136.226','view')

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