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Single RT Treatment Relieves Spinal Compression Symptoms

By MedImaging International staff writers
Posted on 16 Jun 2017

Image: A new study shows a single dose of radiation therapy can treat metastatic spinal cord compression (Photo courtesy of NCI).

A new study suggests that a single radiation therapy (RT) treatment is as effective as a full week of RT for treating spinal cord compression (SCC), a common complication of metastatic cancer.

The phase III clinical trial, conducted at Mount Vernon Cancer Centre (Northwood, United Kingdom), enrolled 688 patients (median 70 years, 73% male) with metastatic prostate (44%), lung (18%), breast (11%), and gastrointestinal cancers (11%). The researchers randomly assigned the patients to receive external beam spinal canal radiation therapy either as a single dose of 8 Gy or as a 20 Gy dose split in five doses over five days. The primary endpoint of the study was ambulatory status, measured on a four-point scale.

The results showed that at eight weeks, 69.5% of patients who received single-dose RT and 73.3% of those who received five doses had ambulatory status 1 (normal walking) or 2 (able to walk with walking aid), showing that both shorter- and longer-course RT treatments helped patients stay mobile. The median overall survival was similar in both groups, as were side effects, but mild side effects were less common in the single-dose group. The study was presented at the American Society of Clinical Oncology (ASCO) annual meeting, held during June 2017 in Chicago (IL, USA).

“Our findings establish single-dose radiotherapy as the standard of care for metastatic spinal canal compression, at least for patients with a short life expectancy. For patients, this means fewer hospital visits and more time with family,” said lead author and study presenter oncologist Peter Hoskin, MD. “Longer radiation may be more effective for preventing regrowth of metastases in the spine than single-dose radiation. Therefore, a longer course of radiation may still be better for patients with a longer life expectancy, but we need more research to confirm this.”

Metastatic SCC is a spinal cord or cauda equina compression by direct pressure and/or induction of vertebral collapse or instability, which leads to irreversible neurological damage such as paraplegia or tetraplegia, depending on the level of the lesion. Up to 10% of all cancer patients will have metastatic SCC, and early diagnosis and treatment are essential to prevent permanent neurological damage.

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Mount Vernon Cancer Centre

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69 (41.961669921875): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (!!!!! 1889.9440765381): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294769639 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (461.10153198242): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294769639 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 25102.138519287): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 2597.0935821533): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (122.0703125): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (!!!!! 2948.9994049072): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (99.897384643555): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (101.08947753906): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294769639 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (36.001205444336): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294769639 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (38.862228393555): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 3791.0938262939): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (117.06352233887): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (58.174133300781): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (109.19570922852): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (128.98445129395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

105 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

106 (98.943710327148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294769639 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (701.904296875): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294769639 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 6271.1238861084): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

109 (178.09867858887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

110 (83.92333984375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294769639 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (735.04447937012): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294769639 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (933.88557434082): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 2000.093460083): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (874.04251098633): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

115 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

116 (!!!!! 1157.9990386963): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

117 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

118 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

119 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

120 (447.03483581543): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 49570.083618164): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (996.11282348633): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

123 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

124 (953.19747924805): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294769639 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294769639 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 1421357.8701019): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (96.08268737793): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (468.01567077637): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (59.127807617188): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (584.84077453613): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (180.95970153809): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (576.97296142578): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (155.92575073242): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (401.97372436523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (360.01205444336): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (161.88621520996): SELECT name FROM jos_deeppockets WHERE id=213

136 (30.994415283203): SELECT name FROM jos_deeppockets WHERE id=213

137 (430.82237243652): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (461.10153198242): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

140 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

141 (!!!!! 6860.9714508057): TRUNCATE TABLE jos_trademed_module

142 (428.91502380371): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294769639 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (146.86584472656): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294769639 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (505.92422485352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (128.98445129395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

147 (596.04644775391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

148 (!!!!! 5771.8753814697): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (94.175338745117): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

150 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

151 (79.870223999023): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294769639 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294769639 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (33.140182495117): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

153 (28.133392333984): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

154 (34.093856811523): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (127.07710266113): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

156 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769639 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769639 AND published='1' LIMIT 1

157 (131.13021850586): select jos_twitters.link from jos_twitters where cat=10

158 (31.948089599609): select jos_facebook.link from jos_facebook where cat=10

159 (33.855438232422): select jos_google_plus.link from jos_google_plus where cat=10

160 (35.04753112793): select jos_linkedin.link from jos_linkedin where cat=10

161 (293.97010803223): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 6648.063659668): insert into jos_banners_delta values (14615,'2025-04-30 13:58:08','18.117.145.188','view'),(14202,'2025-04-30 13:58:08','18.117.145.188','view'),(14203,'2025-04-30 13:58:08','18.117.145.188','view')

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