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Multi-Parametric MRI and PET Imaging Improve Accuracy of Prostate Cancer Biopsies

By MedImaging International staff writers
Posted on 25 Jul 2016

Image: The graphic shows Gleason 3+4 prostate cancer in T2-weighted (A) and diffusion-weighted (B) MRI images. Graphic (C) shows F-18-choline PET, and graphic (D) shows PET/MRI (D) (Photo courtesy of the University of Michigan).

Researchers have demonstrated that a combination of PET and multi-parametric MR imaging can improve targeted prostate cancer biopsies.

The study was published in the July 2016 issue of The Journal of Nuclear Medicine and found that adding F-18-choline Positron Emission Tomography (PET) molecular imaging to multi-parametric Magnetic Resonance Imaging (mpMRI) improves the chance of recognizing significant prostate cancer during targeted trans-rectal prostate biopsies.

The study, part of an ongoing prospective clinical trial was carried out by researchers at the University of Michigan (UMS; Ann Arbor, MI, USA) and included 36 subjects of which 15 were eventually identified with significant prostate cancer. The researchers concluded that image registration using fusion PET imaging together with MRI real-time Trans-Rectal Ultrasound (TRUS) during targeted prostate biopsies was accurate and clinically feasible. The addition of F-18-choline PET, to the mpMRI procedure resulted in improved identification of significant prostate cancer.

Morand Piert, MD, radiology professor, Division of Nuclear Medicine, University of Michigan, said, "Our positive results suggest that in the future, PET/MRI may become a one-stop imaging test for men with suspected but undetected prostate cancer or for patients undergoing surveillance for known low-risk prostate cancer. Since prostate cancer is often multi-focal and presents with multiple lesions of varying risk, it is important to identify the lesions that harbor the greatest malignant potential. Accurate identification of clinically significant cancer and avoidance of clinically insignificant cancer is the centerpiece of modern prostate cancer diagnosis. The use of advanced imaging to inform placement of biopsy needles promises to greatly minimize the uncertainty associated with prostate cancer care."

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67 (40.054321289062): select jos_linkedin.link from jos_linkedin where cat=10

68 (36.954879760742): SELECT fid FROM jos_deeppockets WHERE id=294765250 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294765250 AND published='1' LIMIT 1

69 (43.869018554688): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (300.16899108887): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294765250 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (195.02639770508): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294765250 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (51.021575927734): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 1878.9768218994): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (174.04556274414): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (!!!!! 1611.9480133057): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (!!!!! 1876.1157989502): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (74.148178100586): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (499.96376037598): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294765250 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (58.889389038086): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294765250 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (!!!!! 1629.114151001): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 1059.0553283691): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (178.09867858887): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (518.0835723877): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (121.11663818359): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (812.05368041992): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (247.00164794922): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (!!!!! 3562.9272460938): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (!!!!! 7321.1193084717): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (!!!!! 6207.2277069092): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 7169.9619293213): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

105 (!!!!! 1146.0781097412): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

106 (488.0428314209): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294765250 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (384.09233093262): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294765250 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 1399.9938964844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

109 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

110 (277.04238891602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294765250 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (627.99453735352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294765250 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 1186.1324310303): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 2205.1334381104): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (215.05355834961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

115 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

116 (598.90747070312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

117 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

118 (741.00494384766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

119 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

120 (658.03527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

121 (48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

122 (329.01763916016): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 44296.026229858): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 10262.012481689): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294765250 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294765250 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 16288.042068481): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 2316.951751709): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (524.99771118164): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (360.01205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (265.83671569824): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (39.815902709961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 2486.9441986084): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (373.12507629395): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (185.01281738281): SELECT name FROM jos_deeppockets WHERE id=213

138 (51.021575927734): SELECT name FROM jos_deeppockets WHERE id=213

139 (579.1187286377): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (550.0316619873): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (722.88513183594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

142 (!!!!! 3653.0494689941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

143 (!!!!! 18922.805786133): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 7361.888885498): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294765250 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (636.81602478027): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294765250 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (450.84953308105): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

149 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

150 (!!!!! 1590.0135040283): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 2068.042755127): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

152 (118.97087097168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

153 (77.009201049805): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294765250 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294765250 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (735.99815368652): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (82.015991210938): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (68.902969360352): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

158 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765250 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765250 AND published='1' LIMIT 1

159 (!!!!! 2936.1248016357): select jos_twitters.link from jos_twitters where cat=10

160 (85.830688476562): select jos_facebook.link from jos_facebook where cat=10

161 (543.11752319336): select jos_google_plus.link from jos_google_plus where cat=10

162 (82.969665527344): select jos_linkedin.link from jos_linkedin where cat=10

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