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Chemoradiation May Help Increase Cancer Survival Rates

By MedImaging International staff writers
Posted on 07 Mar 2016

The addition of chemotherapy to radiation therapy (RT) improves survival rates among a subset of septuagenarian head and neck cancer patients, according to a new study.

Researchers at the University of Colorado (Anschutz; Aurora, USA) queried the US National Cancer Data Base (NCDB) for records of patients older than 70 years who were treated for non-metastatic head and neck squamous cell carcinoma (HNSCC) cancers between 1998 and 2011. The patients were then divided into two groups, based on whether or not patients received chemotherapy concurrent with RT (CRT), defined as beginning a course of chemotherapy within 14 days of RT.

The results showed that 68% of the patients received RT alone, and 32% received CRT. When compared to RT alone, CRT demonstrated a survival benefit among septuagenarians that was similar to that of younger HNSCC patients with limited comorbidity and later-stage disease. Specifically, CRT was beneficial for patients 71–79 years of age with low comorbidity scores and advanced disease stage. The study was presented at the annual Multidisciplinary Head and Neck Cancer Symposium, held during February 2016 in Scottsdale (AZ, USA).

“Because the toxicity of concurrent chemoradiation is greater than radiation alone for definitive HNSCC treatment, many clinicians have reservations about offering CRT for elderly head and neck cancer patients,” said senior author and study presenter Sana Karam, MD, PhD, assistant professor of radiation oncology at Anschutz. “However, in the era of improved radiation techniques, improved systemic therapy and better supportive care, we find that CRT does, in fact, improve survival for a large segment of this population.”

HNSCC develops in the mucous membranes of the mouth, nose, and throat, and is classified by its location: the oral cavity, the oropharynx, the nasal cavity and paranasal sinuses, the nasopharynx, the larynx, and the hypopharynx. The can also be grouped into wider oropharyngeal, laryngeal, and hypopharyngeal cancers. Depending on the location, the cancer can cause ulcerations, unusual bleeding or pain, sinus congestions, pain when swallowing or difficulty swallowing, a hoarse voice, difficulty breathing, or enlarged lymph nodes.

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70 (257.96890258789): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294763090 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (203.84788513184): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294763090 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (36.954879760742): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (56.028366088867): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294763090 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (28.848648071289): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294763090 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (32.901763916016): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

105 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

106 (50.783157348633): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294763090 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (45.061111450195): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294763090 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

109 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

110 (68.902969360352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294763090 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (597.95379638672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294763090 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (551.93901062012): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (318.05038452148): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

115 (48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

116 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

117 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

118 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

119 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

120 (293.01643371582): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 22893.905639648): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (144.00482177734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

123 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

124 (507.11631774902): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294763090 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294763090 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 420642.8527832): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (92.983245849609): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (56.982040405273): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (63.896179199219): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (58.889389038086): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (28.848648071289): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (494.95697021484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (343.79959106445): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (269.17457580566): SELECT name FROM jos_deeppockets WHERE id=213

136 (46.014785766602): SELECT name FROM jos_deeppockets WHERE id=213

137 (551.93901062012): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (468.01567077637): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

140 (52.213668823242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

141 (!!!!! 9577.9895782471): TRUNCATE TABLE jos_trademed_module

142 (95.129013061523): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294763090 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (53.167343139648): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294763090 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (458.0020904541): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

147 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

148 (!!!!! 1382.1125030518): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

150 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

151 (56.982040405273): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294763090 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294763090 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (584.84077453613): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

153 (41.961669921875): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

154 (46.014785766602): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (109.91096496582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

156 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294763090 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294763090 AND published='1' LIMIT 1

157 (54.836273193359): select jos_twitters.link from jos_twitters where cat=10

158 (36.954879760742): select jos_facebook.link from jos_facebook where cat=10

159 (37.908554077148): select jos_google_plus.link from jos_google_plus where cat=10

160 (36.954879760742): select jos_linkedin.link from jos_linkedin where cat=10

161 (350.9521484375): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1410.0074768066): insert into jos_banners_delta values (14615,'2025-05-01 20:45:54','18.218.65.88','view'),(14202,'2025-05-01 20:45:54','18.218.65.88','view'),(14203,'2025-05-01 20:45:54','18.218.65.88','view')

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