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More Accurate PET Imaging Biomarker Developed for Detecting Prostate Cancer

By MedImaging International staff writers
Posted on 01 Feb 2016

Positron Emission Tomography (PET) imaging combined with a new experimental agent can detect 97% of prostate cancers—more than those detected by pathologists when examining prostate glands that were excised.

The findings were published online in the journal Urology. The new method is better at detecting prostate cancer than any radiographical, biopsy or blood test currently in use. The study cohort consisted of 25 men suffering from prostate cancer who opted to have their prostate glands removed in a radical prostatectomy operation. Before the operation the men underwent the new imaging test.

The researchers from the Thomas Jefferson University (Philadelphia PA, USA) compared the results of the imaging test, and the examination by the pathologists. The imaging test uses a new biomarker, 64Cu-TP3805, and is administered to patients intravenously before they undergo a PET/CT (Computed Tomography) scan. The biomarker attaches itself to VPAC1 receptors on the surface of cancer cells. In addition, a radiation emitting copper peptide, Cu-64, is hooked onto the biomarker TP3805. PET Imaging can then be used to find where in the prostate the 64Cu-TP3805 has attached itself to cancer cells. The radioactive agent Cu-64 decays rapidly and has a lower whole-body radiation risk than a CT scan.

The results of the study showed that the new test identified 97%, or 105 out of 107 cancerous lesions found by the pathologists in the excised prostate glands, and nine additional lesions that were not found in the pathologic exam. The researchers also successfully investigated the use of 64Cu-TP3805 in human breast cancer, and are investigating the use of the test in animal models of bladder and lung cancer.

Senior investigator of the study, Mathew Thakur, PhD, professor of Radiology at the Thomas Jefferson University Sidney Kimmel Medical College, said, “There is a critical need for an accurate method to detect and stage prostate cancer so that the disease can be precisely managed. We believe this method has that potential. Current tests now used are inexact because they all require an invasive biopsy and these costly biopsies—which have the potential for complications—can miss 66% of cancers. It is hard to believe that hundreds of thousands of patients in the US have been relying on biopsies to dictate their treatment, when two-thirds of these tests do not accurately reflect what is happening inside the prostate. Results of this study exceeded our goal of detecting 80% of cancers seen pathologically, and provided us with real insights into how prostate cancer can be accurately imaged. A larger study that confirms these exciting findings should be conducted.”

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69 (32.901763916016): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (353.81317138672): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294762526 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (227.92816162109): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294762526 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (38.14697265625): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (!!!!! 2633.0947875977): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (80.108642578125): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (48.160552978516): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294762526 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (29.087066650391): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294762526 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (36.001205444336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 2701.0440826416): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

105 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

106 (121.11663818359): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294762526 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (650.88272094727): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294762526 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 2058.9828491211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

109 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

110 (70.810317993164): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294762526 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (586.98654174805): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294762526 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (937.93869018555): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (379.08554077148): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 1811.9812011719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

115 (274.8966217041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

116 (437.97492980957): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

117 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

118 (!!!!! 3695.011138916): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

119 (!!!!! 5915.8802032471): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

120 (474.92980957031): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 47498.941421509): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (193.11904907227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

123 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

124 (579.833984375): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294762526 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294762526 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 928545.95184326): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 3928.1845092773): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (299.21531677246): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (338.07754516602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (126.12342834473): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (70.810317993164): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (92.983245849609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (382.90023803711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (366.9261932373): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (125.16975402832): SELECT name FROM jos_deeppockets WHERE id=213

136 (30.040740966797): SELECT name FROM jos_deeppockets WHERE id=213

137 (423.90823364258): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (396.0132598877): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

140 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

141 (!!!!! 5258.0833435059): TRUNCATE TABLE jos_trademed_module

142 (77.962875366211): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294762526 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294762526 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (500.91743469238): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (895.02334594727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

147 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

148 (!!!!! 1272.9167938232): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

150 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

151 (298.02322387695): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294762526 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294762526 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (607.96737670898): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

153 (863.07525634766): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

154 (!!!!! 1023.0541229248): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (115.87142944336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

156 (117.06352233887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762526 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762526 AND published='1' LIMIT 1

157 (61.988830566406): select jos_twitters.link from jos_twitters where cat=10

158 (27.894973754883): select jos_facebook.link from jos_facebook where cat=10

159 (25.98762512207): select jos_google_plus.link from jos_google_plus where cat=10

160 (34.093856811523): select jos_linkedin.link from jos_linkedin where cat=10

161 (921.96464538574): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 2338.171005249): insert into jos_banners_delta values (14615,'2025-05-01 18:46:50','3.15.160.18','view'),(14202,'2025-05-01 18:46:50','3.15.160.18','view'),(14203,'2025-05-01 18:46:50','3.15.160.18','view')

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