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Technique Enables More Effective PET Scanning to Detect Cancer, Heart Conditions

By MedImaging International staff writers
Posted on 04 Nov 2014

A novel technique that reduces image degradation caused by respiratory motion during a positron emission tomography (PET) imaging scan was recently developed. The new technique is based on bioimpedance measurement, and it allows for image reconstruction at a specific phase of the patient’s breathing pattern. This, in turn, makes it possible to reduce image degradation caused by motion.

The new technique was presented in the PhD thesis of Tuomas Koivumäki, MSc (Tech), from the University of Eastern Finland (Joensuu, Finland), and is based on bioimpedance measurement. The strategy allows for image reconstruction at a specific phase of the patient’s breathing pattern. This, in turn, makes it possible to reduce image degradation caused by motion.

In the future, the newly developed technique will enable increasingly accurate image acquisition especially during PET scans performed to detect cancers of the chest and upper abdomen, and inflammatory disorders of the heart.

Due to enhanced image quality, PET images provide new and increasingly accurate data, potentially improving diagnosis effectiveness and treatment response monitoring. High-quality image data make the treatment more efficient, both medically and financially.

The study revealed that when synchronizing images on the basis of bioimpedance, it was possible to discern smaller details. Motion compensation also significantly influenced the parameters measured from the images. Bioimpedance measurement offers a straightforward technique for acquiring the data needed for motion compensation. Furthermore, the technique can be easily integrated into electrocardiogram (ECG) measurement, which is widely used to monitor heart function during the scan.

In techniques based on bioimpedance measurement, a very weak electrical current is passed through the patient's chest, and changes in the resulting voltage are measured. The voltage has been observed to change according to the patient’s breathing and cardiac function. Earlier, bioimpedance measurements have been used to assess, for example, body composition, fluid accumulations in lungs, and indicators of cardiac function.

The study focused on the feasibility of bioimpedance-based measurement techniques for respiratory and cardiac motion compensation in PET imaging. The study first used computational models and test subjects to determine an optimized bioimpedance measurement configuration for simultaneous measurement of respiratory and cardiac gating signals. The second phase of the study focused on analyzing whether bioimpedance techniques can be used to reduce respiration-related degradation of PET images.

PET scanning is used for cancer staging and evaluating treatment response, as well as for studying myocardial blood flow and inflammatory diseases of the heart. Typically, a PET scan takes several minutes, which is why movement caused by the patient’s breathing inevitably degrades image quality. Degraded image quality caused by respiratory motion has been reported to affect PET scanning performed to detect specifically cancer and heart conditions. At worst, image degradation may lead to a wrong diagnosis and inadequate or unnecessary treatment.

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69 (36.954879760742): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (295.87745666504): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294755487 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (324.01084899902): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294755487 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (42.200088500977): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (142.09747314453): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (74.148178100586): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294755487 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (36.001205444336): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294755487 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (36.001205444336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (381.9465637207): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (154.01840209961): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (341.17698669434): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (91.791152954102): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (327.82554626465): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (168.0850982666): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (434.16023254395): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (463.00888061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

105 (298.02322387695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

106 (98.943710327148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294755487 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (810.86158752441): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294755487 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (996.82807922363): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

109 (234.12704467773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

110 (102.04315185547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294755487 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (773.90670776367): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294755487 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (910.99739074707): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (576.97296142578): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (213.1462097168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

115 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

116 (153.0647277832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

117 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

118 (152.8263092041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

119 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

120 (420.09353637695): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 55650.949478149): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (151.15737915039): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

123 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

124 (437.97492980957): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294755487 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294755487 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 614114.99977112): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 10529.041290283): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 1367.0921325684): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (149.01161193848): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (281.81076049805): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (45.7763671875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (165.93933105469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (49.829483032227): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (416.04042053223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (273.9429473877): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (149.96528625488): SELECT name FROM jos_deeppockets WHERE id=213

136 (59.127807617188): SELECT name FROM jos_deeppockets WHERE id=213

137 (566.00570678711): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (617.02728271484): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (79.870223999023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

140 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

141 (!!!!! 8249.9980926514): TRUNCATE TABLE jos_trademed_module

142 (175.95291137695): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294755487 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (105.85784912109): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294755487 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (452.04162597656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (245.09429931641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

147 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

148 (!!!!! 1471.0426330566): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

150 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

151 (87.976455688477): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294755487 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294755487 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (504.0168762207): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

153 (95.129013061523): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

154 (!!!!! 3170.0134277344): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (!!!!! 2928.9722442627): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

156 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1' LIMIT 1

157 (242.94853210449): select jos_twitters.link from jos_twitters where cat=10

158 (176.90658569336): select jos_facebook.link from jos_facebook where cat=10

159 (32.186508178711): select jos_google_plus.link from jos_google_plus where cat=10

160 (25.98762512207): select jos_linkedin.link from jos_linkedin where cat=10

161 (349.04479980469): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1756.9065093994): insert into jos_banners_delta values (14615,'2025-05-02 09:37:32','3.137.161.250','view'),(14202,'2025-05-02 09:37:32','3.137.161.250','view'),(14203,'2025-05-02 09:37:32','3.137.161.250','view')

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