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PET Imaging Reveals Brain Benefits from Weight Loss After Bariatric Surgery

By MedImaging International staff writers
Posted on 31 Aug 2014

Imaging studies revealed that weight loss surgery has been found to suppress changes in brain metabolism associated with obesity and improve cognitive function involved in planning, strategizing, and organizing. Therefore, researchers have hypothesized that a specific surgical procedure could reduce risk of Alzheimer’s in obese people.

The findings were published online August 26, 2014, in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM). Obesity can overload the brain as well as other organs and obese individuals face a 35% higher risk of developing Alzheimer’s disease compared to normal weight people. Bariatric surgery is used for individuals who are severely obese lose weight by restricting the amount of food they can eat before feeling satiated by reducing the stomach’s size or limit the absorption of nutrients by removing part of the small intestine from the path food takes through the digestive tract. Some procedures, such as Roux-en-Y gastric bypass (RYBG) surgery, use a combination of these techniques. This study was the first to assess brain activity in women before and after bariatric surgery.

“When we studied obese women prior to bariatric surgery, we found some areas of their brains metabolized sugars at a higher rate than normal weight women,” said one of the study’s authors, Cintia Cercato, MD, PhD, from the University of Sao Paolo (Brazil). “In particular, obesity led to altered activity in a part of the brain linked to the development of Alzheimer’s disease—the posterior cingulate gyrus. Since bariatric surgery reversed this activity, we suspect the procedure may contribute to a reduced risk of Alzheimer’s disease and other forms of dementia.”

The longitudinal study examined the effect of RYBG surgery on the brain function of 17 obese women. Researchers used positron emission tomography (PET) imaging scans and neuropsychologic tests to evaluate brain function and activity in the participants prior to surgery and six months after the procedure. The same tests also were run once on a control group of 16 lean women.

The obese women, before undergoing surgery, had higher rates of metabolism in specific regions of the brain, including the posterior cingulate gyrus. Following surgery, there was no evidence of this exacerbated brain activity. Their brain metabolism rates were comparable to the activity seen in normal weight women. After surgery, the obese women also performed better on a test gauging executive function than they did before the procedures. Executive function is used in planning, organizing, and strategizing. Five other neuropsychologic tests measuring various aspects of memory and cognitive function demonstrated no change following the surgery.

“Our findings suggest the brain is another organ that benefits from weight loss induced by surgery,” Dr. Cercato concluded. “The increased brain activity the obese women exhibited before undergoing surgery did not result in improved cognitive performance, which suggests obesity may force the brain to work harder to achieve the same level of cognition.”

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69 (35.04753112793): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (310.89782714844): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754258 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (241.99485778809): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754258 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (40.054321289062): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (72.002410888672): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (67.949295043945): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754258 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (40.054321289062): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754258 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (42.915344238281): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (69.856643676758): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (117.06352233887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

105 (!!!!! 5747.7951049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

106 (130.89179992676): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754258 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (90.122222900391): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754258 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 1132.9650878906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

109 (125.16975402832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

110 (118.01719665527): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294754258 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (861.88316345215): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294754258 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (566.00570678711): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (370.97930908203): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (79.154968261719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

115 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

116 (114.91775512695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

117 (108.95729064941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

118 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

119 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

120 (443.93539428711): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 19655.94291687): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (136.8522644043): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

123 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

124 (583.88710021973): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754258 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754258 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 499892.95005798): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (78.916549682617): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (55.074691772461): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (33.855438232422): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (547.88589477539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (416.99409484863): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (262.02201843262): SELECT name FROM jos_deeppockets WHERE id=213

136 (51.021575927734): SELECT name FROM jos_deeppockets WHERE id=213

137 (487.08915710449): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (560.04524230957): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

140 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

141 (!!!!! 9431.8389892578): TRUNCATE TABLE jos_trademed_module

142 (109.91096496582): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754258 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (60.081481933594): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754258 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (860.92948913574): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

147 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

148 (!!!!! 1281.0230255127): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

150 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

151 (65.088272094727): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754258 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754258 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (586.98654174805): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

153 (42.915344238281): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

154 (33.140182495117): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

156 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754258 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754258 AND published='1' LIMIT 1

157 (53.882598876953): select jos_twitters.link from jos_twitters where cat=10

158 (38.862228393555): select jos_facebook.link from jos_facebook where cat=10

159 (35.04753112793): select jos_google_plus.link from jos_google_plus where cat=10

160 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

161 (262.02201843262): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1722.0973968506): insert into jos_banners_delta values (14615,'2025-06-19 05:08:31','216.73.216.120','view'),(14202,'2025-06-19 05:08:31','216.73.216.120','view'),(14203,'2025-06-19 05:08:31','216.73.216.120','view')

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