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Identifying Brain Networks Using Metabolic Brain Imaging-Based Mapping Strategy

By MedImaging International staff writers
Posted on 31 Jul 2014

A new image-based strategy has been used to identify and gauge placebo effects in randomized clinical trials for brain disorders. More...

The researchers employed a network mapping technique to identify specific brain circuits underlying the response to sham surgery in Parkinson’s disease (PD).

The study’s findings were published in the July 18, 2014, in the Journal of Clinical Investigation. PD is the second most common neurodegenerative disease in the United States. Those who suffer from Parkinson’s disease most frequently experience tremors, slowness of movement (bradykinesia), rigidity, and impaired balance and coordination. Patients may have a hard time talking, walking, or completing simple daily tasks. They may also experience depression and difficulty sleeping due to the disease. The current standard for diagnosis of PD disease relies on a skilled healthcare professional, typically an experienced neurologist, to determine through clinical examination that someone has it. Currently, there is no cure for PD, but drugs can improve symptoms.

Investigators from the Feinstein Institute’s Center for Neurosciences (Manhasset, NY, USA), led by David Eidelberg, MD, has developed a strategy to identify brain patterns that are abnormal or indicate disease using 18-F flurorodeoxyglucose (FDG) positron emission tomography (PET) metabolic imaging techniques. Up to now, this approach has been used effectively to identify specific networks in the brain that indicate a patient has or is at risk for PD and other neurodegenerative disorders.

“One of the major challenges in developing new treatments for neurodegenerative disorders such as Parkinson’s disease is that it is common for patients participating in clinical trials to experience a placebo or sham effect,” noted Dr. Eidelberg. “When patients involved in a clinical trial commonly experience benefits from placebo, it’s difficult for researchers to identify if the treatment being studied is effective. In a new study conducted by my colleagues and myself, we have used a new image-based strategy to identify and measure placebo effects in brain disorder clinical trials.”

The researchers used their network mapping technique in this study to identify specific brain circuits underlying the response to sham surgery in PD patients participating in a gene therapy trial. The expression of this network measured under blinded conditions correlated with the sham study participants’ clinical outcome; the network changes were reversed when the subjects learned of their sham treatment status.

Lastly, an individual’s network expression value measured before the treatment predicted his/her subsequent blinded response to sham treatment. This suggests, according to the investigators, that this innovative image-based measure of the sham-related network can help to reduce the number of subjects assigned to sham treatment in randomized clinical trials for brain disorders by excluding those patients who are more liable to display placebo effects under blinded conditions.

Related Links:
Feinstein Institute’s Center for Neurosciences

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61 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

62 (!!!!! 4712.8200531006): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

63 (646.82960510254): SELECT fid FROM jos_deeppockets WHERE id=294753757 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294753757 AND published='1' LIMIT 1

64 (97.990036010742): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

65 (77.962875366211): select jos_twitters.link from jos_twitters where cat=10

66 (42.915344238281): select jos_facebook.link from jos_facebook where cat=10

67 (43.153762817383): select jos_google_plus.link from jos_google_plus where cat=10

68 (38.14697265625): select jos_linkedin.link from jos_linkedin where cat=10

69 (53.882598876953): SELECT fid FROM jos_deeppockets WHERE id=294753757 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294753757 AND published='1' LIMIT 1

70 (46.968460083008): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

71 (317.81196594238): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753757 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (203.84788513184): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753757 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (59.843063354492): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

74 (144.00482177734): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (699.04327392578): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (123.02398681641): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (162.83988952637): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (504.97055053711): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (127.07710266113): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (164.98565673828): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (568.86672973633): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (!!!!! 3998.0411529541): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (198.1258392334): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (455.85632324219): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (!!!!! 3123.9986419678): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (90.122222900391): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (108.00361633301): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753757 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (51.975250244141): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753757 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (59.127807617188): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

91 (92.029571533203): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (149.96528625488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

106 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

107 (711.20262145996): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753757 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (102.04315185547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753757 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (146.15058898926): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

110 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

111 (108.95729064941): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294753757 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (576.97296142578): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294753757 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (778.9134979248): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (599.14588928223): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (!!!!! 1712.0838165283): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

116 (116.10984802246): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

117 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

118 (49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

119 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

120 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

121 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

122 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

123 (499.01008605957): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

124 (!!!!! 65186.977386475): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

125 (723.12355041504): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753757 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753757 AND type='deeppockets_item' AND published='1' LIMIT 1

126 (!!!!! 21323.919296265): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (353.09791564941): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (92.983245849609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (103.95050048828): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (164.98565673828): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (63.896179199219): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (485.18180847168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (56.028366088867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (50.067901611328): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (!!!!! 14187.812805176): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (844.00177001953): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (57.93571472168): SELECT name FROM jos_deeppockets WHERE id=213

139 (35.04753112793): SELECT name FROM jos_deeppockets WHERE id=213

140 (734.09080505371): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (582.93342590332): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (85.830688476562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

143 (79.870223999023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

144 (!!!!! 19562.005996704): TRUNCATE TABLE jos_trademed_module

145 (370.97930908203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753757 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (815.86837768555): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753757 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (!!!!! 2867.9370880127): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (119.92454528809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (121.11663818359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

150 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

151 (!!!!! 1894.9508666992): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

152 (!!!!! 1241.92237854): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

153 (134.94491577148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

154 (100.13580322266): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753757 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753757 AND type='deeppockets_item' AND published='1' LIMIT 1

155 (61.988830566406): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (!!!!! 1538.9919281006): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

157 (100.85105895996): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

158 (143.05114746094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

159 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753757 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753757 AND published='1' LIMIT 1

160 (70.095062255859): select jos_twitters.link from jos_twitters where cat=10

161 (41.961669921875): select jos_facebook.link from jos_facebook where cat=10

162 (36.001205444336): select jos_google_plus.link from jos_google_plus where cat=10

163 (51.021575927734): select jos_linkedin.link from jos_linkedin where cat=10

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