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Enhanced PET Imaging Radiotracers Designed for Better Tracking of Disease

By MedImaging International staff writers
Posted on 09 Jun 2014

Scientists have developed a direct approach for making single enantiomer positron emission tomography (PET) tracers.

Small molecules containing a radioactive isotope of fluorine called ¹⁸F radiotracers are used to detect and track specific diseases in patients. When injected into the body, these molecules collect in specific targets, such as tumors, and can be visualized by their radioactive tag on a PET imaging scan. The ¹⁸F tags rapidly decay, therefore, no radioactivity remains after approximately one day.

But there are only a few strategies available for making ¹⁸F radiotracers. Furthermore, existing techniques tend to require harsh conditions that jumble the placement of a radiotracer’s more delicate chemical bonds. Researchers at Princeton University (Princeton, NJ, USA) reported that they now have a way to produce ¹⁸F radiotracers that avoids that problem. “It’s the first method to do enantio-selective carbon-¹⁸F bond formation,” said lead investigator Dr. Abigail Doyle, a Princeton associate professor of chemistry.

Radiotracers up to now have mostly been evaluated as mixtures of enantiomers. Enantiomers are molecules that are totally identical in composition but the arrangement of atoms at the chiral center are mirror images. A chiral center is an atom, typically carbon, which is connected to four different groups. “We know in biology, small molecule interactions with enzymes often depend on the 3D [three-dimensional] properties of the molecule. Being able to prepare the enantiomers of a given chiral tracer, in order to optimize which tracer has the best binding and imaging properties could be really useful,” Dr. Doyle said.

The researchers developed a cobalt fluoride catalyst—[¹⁸F](salen)CoF—to install the radioactive fluoride through the ring-opening reaction of epoxides. Their approach demonstrated excellent enantioselectivity for 11 substrates, five of which are known pre-clinical PET tracers. With this new method, researchers can now assess single enantiomers of existing or new PET radiotracers and evaluate if these compounds offer any benefits over the enantiomeric combinations. Eventually, the goal is to use this chemistry to identify a completely new PET radiotracer for imaging.

Currently, there are only four US Food and Drug Administration (FDA)-approved ¹⁸F radiotracers. One of the major limitations to discovering PET tracers is the fact that the only commercially available source of ¹⁸F is nucleophilic fluoride. Existing ¹⁸F sources are very basic, and during the process of making the ¹⁸F radiotracer, can cause the elimination of alcohol and amine groups and rearrange the groups around a chiral center in a process called racemization. Under Dr. Doyle’s less basic reaction conditions, even alcohols and secondary amines are tolerated and no racemization is seen.

“Forming carbon-fluorine bonds by nucleophilic fluoride is challenging. One typically needs to use high temperatures or else the reactions are too slow to permit radioisotope incorporation,” Dr. Doyle commented. “Whereas most reactions require temperatures greater than 100° Celsius, our reaction can be run at 50° Celsius.”

Small amounts of radioactivity were sufficient to develop the reaction at first but to perform imaging studies, larger amounts of radioactivity are necessary. “When you go to higher activity, that’s when you do automated chemistry in a hot cell, which is basically a block of lead so you get no exposure,” Dr. Doyle said.

To be efficient in an industrial environment, the chemistry needs to be converted from the laboratory to an automated hot cell. The researchers were given access to an automated hot cell nearby at Merck’s West Point (PA, USA) site. The whole process of radiolabeling takes about 30 to 45 minutes when it is automated. The set-up includes a robotic arm that delivers solutions to designated vials, a high-performance liquid chromatography (HPLC) system and a rotary evaporator, which are devices for the analysis and purification of the radiotracers.

“The catalyst is very robust and the fact that we can translate the reaction directly to the hot cell bodes very well for non-experts to be able to run these sorts of reactions,” Dr. Doyle concluded. “We demonstrated that the radioactivity is high enough that we could actually use it for imaging. That’s an exciting next step.”

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60 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

61 (92.983245849609): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (550.0316619873): SELECT fid FROM jos_deeppockets WHERE id=294752886 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294752886 AND published='1' LIMIT 1

63 (53.167343139648): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (51.021575927734): select jos_twitters.link from jos_twitters where cat=10

65 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

66 (31.232833862305): select jos_google_plus.link from jos_google_plus where cat=10

67 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

68 (32.186508178711): SELECT fid FROM jos_deeppockets WHERE id=294752886 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294752886 AND published='1' LIMIT 1

69 (32.901763916016): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (292.06275939941): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752886 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (290.87066650391): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752886 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (43.869018554688): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (43.153762817383): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752886 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752886 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (34.093856811523): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

105 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

106 (55.074691772461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752886 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752886 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

109 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

110 (58.889389038086): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752886 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (512.83836364746): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752886 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (505.92422485352): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (316.14303588867): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

115 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

116 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

117 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

118 (108.95729064941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

119 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

120 (253.20053100586): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 19215.822219849): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (118.01719665527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

123 (49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

124 (380.03921508789): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752886 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752886 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 548933.98284912): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (87.976455688477): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (28.848648071289): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (494.00329589844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (430.10711669922): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (50.067901611328): SELECT name FROM jos_deeppockets WHERE id=213

136 (34.093856811523): SELECT name FROM jos_deeppockets WHERE id=213

137 (603.19900512695): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (422.00088500977): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

140 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

141 (!!!!! 9377.0027160645): TRUNCATE TABLE jos_trademed_module

142 (139.95170593262): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752886 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (69.141387939453): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752886 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (531.91184997559): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

147 (52.213668823242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

148 (!!!!! 1079.797744751): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

150 (49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

151 (43.869018554688): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752886 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752886 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (34.809112548828): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

153 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

154 (32.901763916016): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

156 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752886 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752886 AND published='1' LIMIT 1

157 (46.014785766602): select jos_twitters.link from jos_twitters where cat=10

158 (31.948089599609): select jos_facebook.link from jos_facebook where cat=10

159 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

160 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

161 (285.14862060547): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1471.0426330566): insert into jos_banners_delta values (14615,'2025-06-19 04:49:55','216.73.216.120','view'),(14202,'2025-06-19 04:49:55','216.73.216.120','view'),(14203,'2025-06-19 04:49:55','216.73.216.120','view')

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