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Using Sugar-Based Tracers to Improve Detecting Heart Disease with PET

By MedImaging International staff writers
Posted on 30 Jan 2014

An international research team of investigators is evaluating a new sugar-based tracer to help in cardiovascular imaging detection of inflamed high-risk, susceptible artery plaques before they rupture.

The team led by Mount Sinai Heart at Icahn School of Medicine at Mount Sinai (New York, NY, USA) is evaluating its innovative sugar-based tracer contrast agent to be used with positron emission tomography (PET) imaging to help in the identification of lethal inflammation and high-risk vulnerable atherosclerotic plaque inside vessel walls that causes acute heart attacks and strokes.

Their findings, reported January 12, 2014, in the journal Nature Medicine, examined the possible benefits of the imaging agent, fluorodeoxymannose (FDM) sugar-based tracer in comparison to fluorodeoxyglucose (FDG), the current glucose-based tracer widely used in patients undergoing PET imaging.

“Our preclinical testing shows that PET imaging with the radiotracer FDM may potentially offer a more targeted strategy to detect dangerous, high-risk plaques and inflammation that may be associated with serious cardiovascular events,” stated Jagat Narula, MD, PhD, the lead investigator for the study, and director of the Cardiovascular Imaging Program at The Mount Sinai Hospital, and associate dean of global health at Icahn School of Medicine at Mount Sinai.

Glucose forms the source of chief energy supply in the human body, and in the radiolabeled form, FDG has been traditionally used for the identification of atherosclerosis. Valentin Fuster, MD, PhD, the director of the Mount Sinai Heart and physician-in-chief of The Mount Sinai Hospital, was one of the earliest investigators to use FDG for the detection of atherosclerosis.

A known biomarker for high inflammation in arterial plaque is the presence of an abundant level of macrophage cells. Macrophage-rich inflammation lining the artery walls filled with plaque is known to be associated with increased risk of heart attack and stroke. “Macrophage cells have a very high metabolic demand for sugars and are dependent on the exogenous source of sugars, and that’s why the sugar-based tracers are able to identify the inflamed or dangerous plaques,” according to Dr. Fuster.

“Although the research team’s investigations of the FDM tracer shows that it performs comparably to the traditional FDG tracer, it is expected that the new sugar tracer may have an advantage to more specifically target inflammation because the plaque infiltrating macrophages develop mannose receptors [MRs],” according to Dr. Narula.

Coauthor Jogeshwar Mukherjee, PhD, and his group of radiochemists from the University of California, Irvine (USA) had labeled the FDM with fluorine-18, which, similar to glucose, enters the cells through glucose transporters. The current study results show mannose is taken up by a specific subset of macrophage cells that dwell in high-risk plaques, which have developed the mannose receptors. This may represent the hypothetic advantage of FDM over the FDG tracer. These macrophages called “M2” within atherosclerotic plaques, are apt to excessively express MRs in inflamed and hemorrhagic arterial lesions, and are particularly common.

In the study, FDG and FDM were compared using PET imaging in atherosclerosis animal models. Whereas uptake of each tracer within atherosclerotic plaques and macrophage cells were similar, according to the researchers the research FDM tracer showed at least a 25% higher FDM uptake advantage due to MR-bearing macrophages.

“The FDM binds to MR-bearing macrophages while FDG does not bind to the MR receptors. This specific binding provides clinically relevant avenue why FDM uptake in high-risk plaques should be further investigated,” said study coauthor Zahi Fayad, PhD, the director of the Translational and Molecular Imaging Institute at Icahn School of Medicine at Mount Sinai. Researchers also observed FDM uptake occurred in the presence of atherosclerosis and nearly none in non-atherosclerosis control models.

“We are excited about our possibly sweeter imaging breakthrough, but further research and clinical trial testing will need to confirm its potential advantage,” stressed Dr. Narula.

“The labeling of FDM is cumbersome and the yield of radiolabeled material is extremely low; the labeling methodology would need to be perfected,” Dr. Mukherjee warned.

Related Links:
Mount Sinai Heart at Icahn School of Medicine at Mount Sinai
University of California, Irvine

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61 (!!!!! 1424.0741729736): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (427.9613494873): SELECT fid FROM jos_deeppockets WHERE id=294750482 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294750482 AND published='1' LIMIT 1

63 (339.03121948242): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (71.048736572266): select jos_twitters.link from jos_twitters where cat=10

65 (27.894973754883): select jos_facebook.link from jos_facebook where cat=10

66 (29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10

67 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

68 (34.093856811523): SELECT fid FROM jos_deeppockets WHERE id=294750482 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294750482 AND published='1' LIMIT 1

69 (33.140182495117): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (175.95291137695): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750482 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (185.96649169922): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750482 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (115.15617370605): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (77.962875366211): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (58.174133300781): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (26.226043701172): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (41.007995605469): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750482 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (27.894973754883): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750482 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (41.007995605469): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (276.08871459961): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (65.088272094727): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (93.936920166016): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (92.029571533203): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (101.08947753906): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (99.897384643555): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (54.836273193359): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (74.863433837891): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (73.909759521484): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1945.972442627): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

105 (123.02398681641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

106 (92.983245849609): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750482 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (72.956085205078): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750482 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (104.90417480469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

109 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

110 (147.81951904297): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750482 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (517.84515380859): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750482 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (544.07119750977): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (379.08554077148): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

115 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

116 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

117 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

118 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

119 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

120 (269.88983154297): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 43343.067169189): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

123 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

124 (443.2201385498): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750482 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750482 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 1353147.0298767): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 823006.15310669): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (125.88500976562): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (49.829483032227): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (601.76849365234): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (622.03407287598): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (319.00405883789): SELECT name FROM jos_deeppockets WHERE id=213

136 (49.829483032227): SELECT name FROM jos_deeppockets WHERE id=213

137 (627.99453735352): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (625.1335144043): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (!!!!! 1451.0154724121): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

140 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

141 (!!!!! 8507.0133209229): TRUNCATE TABLE jos_trademed_module

142 (86.069107055664): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750482 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (944.13757324219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750482 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (375.98609924316): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

147 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

148 (!!!!! 1106.9774627686): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

150 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

151 (370.02563476562): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750482 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750482 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (415.08674621582): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

153 (37.908554077148): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

154 (31.948089599609): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

156 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750482 AND published='1' LIMIT 1

157 (36.954879760742): select jos_twitters.link from jos_twitters where cat=10

158 (25.98762512207): select jos_facebook.link from jos_facebook where cat=10

159 (25.98762512207): select jos_google_plus.link from jos_google_plus where cat=10

160 (25.98762512207): select jos_linkedin.link from jos_linkedin where cat=10

161 (260.82992553711): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 2081.8710327148): insert into jos_banners_delta values (14615,'2025-06-19 10:23:47','216.73.216.120','view'),(14202,'2025-06-19 10:23:47','216.73.216.120','view'),(14203,'2025-06-19 10:23:47','216.73.216.120','view')

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