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HIV Cure Possible Using Radioimmunotherapy

By MedImaging International staff writers
Posted on 18 Dec 2013

Image: Radiolabeled human antibody binds to the viral gp41 protein expressed on the surface of the HIV infected human lymphocyte and the cell is killed by alpha radiation delivered by the antibody (Photo courtesy of RSNA).

Researchers are using radioimmunotherapy (RIT) to destroy remaining human immunodeficiency virus (HIV)-infected cells in the blood samples of patients treated with antiretroviral therapy, offering the potential for an actual cure for HIV infection.

The study’s findings were presented at the annual meeting of the Radiological Society of North America (RSNA), held December 1–6, 2013, in Chicago (IL, USA). Highly active antiretroviral therapy (HAART) has changed the outlook for patients infected with HIV by inhibiting the replication of the virus in the body. However, in spite of the success of HAART in effectively decreasing the burden of HIV, scientists believe reservoirs of latently infected cells persist in the body, preventing the possibility of a permanent cure.

“In an HIV patient on HAART, drugs suppress viral replication, which means they keep the number of viral particles in a patient’s bloodstream very low. However, HAART cannot kill the HIV-infected cells,” said the study’s lead author, Ekaterina Dadachova, PhD, professor of radiology, microbiology and immunology at Albert Einstein College of Medicine (Bronx, NY, USA). “Any strategy for curing HIV infection must include a method to eliminate viral-infected cells.”

Dr. Dadachova and coworkers of the study administered RIT to blood samples from 15 HIV patients treated with HAART at the Einstein-Montefiore Center for AIDS Research. RIT, which has typically been employed to treat cancer, uses monoclonal antibodies—cloned cells that are recruited by the immune system to identify and neutralize antigens. Antigens are foreign objects such as bacteria and viruses that trigger an immune response in the body. The antibody, designed to recognize and bind to a specific cell antigen, is paired with a radioactive isotope. When injected into the patient’s bloodstream, the laboratory-developed antibody travels to the target cell where the radiation is then delivered. “In RIT, the antibodies bind to the infected cells and kill them by radiation,” Dr. Dadachova said. “When HAART and RIT are used together, they kill the virus and the infected cells, respectively.”

Dr. Dadachova’s team combined the monoclonal antibody (mAb2556) designed to target a protein expressed on the surface of HIV-infected cells with the radionuclide bismuth-213. The researchers discovered that RIT was able to kill HIV-infected lymphocytes earlier treated with HAART, decreasing the HIV infection in the blood samples to undetectable levels. “The elimination of HIV-infected cells with RIT was profound and specific,” Dr. Dadachova said. “The radionuclide we used delivered radiation only to HIV-infected cells without damaging nearby cells.”

An important part of the study assessed the ability of the radiolabeled antibody to reach HIV-infected cells in the brain and central nervous system. Using an in vitro human blood-brain-barrier model, the researchers revealed that radiolabeled mAb2556 could cross the blood brain barrier and destroy HIV-infected cells without any overt damage to the barrier itself.

“Antiretroviral treatment only partially penetrates the blood brain barrier, which means that even if a patient is free of HIV systemically, the virus is still able to rage on in the brain, causing cognitive disorders and mental decline,” Dr. Dadachova said. “Our study showed that RIT is able to kill HIV-infected cells both systemically and within the central nervous system.”

Clinical trials in HIV patients are the next phase for the RIT therapy, according to Dr. Dadachova.

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63 (62.942504882812): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (43.869018554688): select jos_twitters.link from jos_twitters where cat=10

65 (32.901763916016): select jos_facebook.link from jos_facebook where cat=10

66 (35.04753112793): select jos_google_plus.link from jos_google_plus where cat=10

67 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

68 (35.04753112793): SELECT fid FROM jos_deeppockets WHERE id=294749756 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294749756 AND published='1' LIMIT 1

69 (32.186508178711): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (370.97930908203): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749756 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (269.88983154297): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749756 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (41.961669921875): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (92.029571533203): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (138.0443572998): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749756 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (51.021575927734): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749756 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (49.114227294922): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (81.062316894531): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (111.10305786133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

105 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

106 (75.101852416992): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749756 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (68.902969360352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749756 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

109 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

110 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294749756 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (708.81843566895): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294749756 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (694.99015808105): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (463.96255493164): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

115 (104.90417480469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

116 (108.95729064941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

117 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

118 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

119 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

120 (308.03680419922): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 20270.109176636): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (156.16416931152): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

123 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

124 (470.16143798828): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749756 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749756 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 441369.05670166): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (129.93812561035): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (56.982040405273): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (28.848648071289): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (33.140182495117): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (575.06561279297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (449.89585876465): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (42.915344238281): SELECT name FROM jos_deeppockets WHERE id=213

136 (30.994415283203): SELECT name FROM jos_deeppockets WHERE id=213

137 (455.85632324219): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (396.9669342041): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

140 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

141 (!!!!! 9891.0331726074): TRUNCATE TABLE jos_trademed_module

142 (92.983245849609): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749756 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (68.902969360352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749756 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (!!!!! 1060.0090026855): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (111.81831359863): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

147 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

148 (!!!!! 1107.931137085): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

150 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

151 (57.93571472168): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749756 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749756 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

153 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

154 (32.901763916016): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

156 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749756 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749756 AND published='1' LIMIT 1

157 (38.14697265625): select jos_twitters.link from jos_twitters where cat=10

158 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

159 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

160 (34.093856811523): select jos_linkedin.link from jos_linkedin where cat=10

161 (226.97448730469): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1585.9603881836): insert into jos_banners_delta values (14615,'2025-06-19 12:16:15','216.73.216.120','view'),(14202,'2025-06-19 12:16:15','216.73.216.120','view'),(14203,'2025-06-19 12:16:15','216.73.216.120','view')

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