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Stroke Risk Assessment Helps Identify Cognitive Decline Early

By MedImaging International staff writers
Posted on 15 Apr 2013

Neuroscientists are employing a brain-imaging application and stroke risk assessment to identify signs of cognitive decline early on in individuals who do not yet show symptoms of dementia.

The connection between stroke risk and cognitive decline has been well established by earlier studies. Individuals with increased stroke risk, as gauged by factors such as high blood pressure, have traditionally performed worse on tests of attention, memory, and abstract reasoning.

This small study demonstrated that not only stroke risk, but also the burden of plaques and tangles, as measured by a brain scan, may influence cognitive decline. The imaging tool used in the study was developed at the University of California, Los Angeles (UCLA; USA) and reveals early signs of amyloid beta “plaques” and neurofibrillary tau “tangles” in the brain—the telltale features of Alzheimer’s disease (AD).

The study, published in the April 2013 issue of the Journal of Alzheimer’s Disease, demonstrated that taking both stroke risk and the burden of plaques and tangles into account might provide a more effective assessment of factors determining how people are doing now and will do in the future. “The findings reinforce the importance of managing stroke risk factors to prevent cognitive decline even before clinical symptoms of dementia appear,” said first author Dr. David Merrill, an assistant clinical professor of psychiatry and biobehavioral sciences at the Semel Institute for Neuroscience and Human Behavior at UCLA.

This is one of the first studies to examine both stroke risk and plaque and tangle levels in the brain in relation to cognitive decline before dementia has even set in, according to Dr. Merrill. According to the researchers, the UCLA brain-imaging tool could be beneficial in monitoring cognitive decline over time and offer additional insight when used with other assessment tools.

For the study, the researchers examined 75 individuals who were healthy or had mild cognitive impairment, a risk factor for the future development of AD. The average age of the participants was 63. The individuals underwent neuropsychologic testing and physical evaluations to calculate their stroke risk using the Framingham Stroke Risk Profile, which examines age, gender, smoking status, systolic blood pressure, diabetes, atrial fibrillation (irregular heart rhythm), use of blood pressure medications, and other factors.

Furthermore, each participant was injected with a chemical marker called FDDNP (fluoroethyl)(methyl)amino[-2-naph- thyl](ethylidene) malononitrile), which binds to deposits of amyloid beta plaques and neurofibrillary tau tangles in the brain. The researchers then used positron emission tomography (PET) to image the brains of the study participants—a method that enabled them to pinpoint where these abnormal proteins accumulate.

The findings demonstrated that greater stroke risk was significantly related to lower performance in several cognitive areas, including language, attention, data-processing speed, memory, visual-spatial functioning, problem-solving, and verbal reasoning.

The researchers, furthermore, observed that FDDNP-binding levels in the brain were linked with participants’ cognitive performance. Study participants, for example, who had greater difficulties with language and problem-solving displayed higher levels of the FDDNP marker in their brain regions that control those cognitive activities.

“Our findings demonstrate that the effects of elevated vascular risk, along with evidence of plaques and tangles, is apparent early on, even before vascular damage has occurred or a diagnosis of dementia has been confirmed,” said the study’s senior author, Dr. Gary Small, director of the UCLA Longevity Center and a professor of psychiatry and biobehavioral sciences who holds the Parlow-Solomon Chair on Aging at UCLA’s Semel Institute.

Researchers discovered that several individual factors in the stroke assessment were significant as predictors of decline in cognitive function, including age, systolic blood pressure, and use of blood pressure-related drugs. Dr. Small noted that the next phase of the research would be studies with a larger sample size to validate and expand the findings.

UCLA owns three US patents on the FDDNP chemical marker. Dr. Small and study author Dr. Jorge Barrio are among the inventors.

Related Links:
University of California, Los Angeles

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62 (631.80923461914): SELECT fid FROM jos_deeppockets WHERE id=294745665 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294745665 AND published='1' LIMIT 1

63 (531.91184997559): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (700.95062255859): select jos_twitters.link from jos_twitters where cat=10

65 (47.922134399414): select jos_facebook.link from jos_facebook where cat=10

66 (333.07075500488): select jos_google_plus.link from jos_google_plus where cat=10

67 (51.021575927734): select jos_linkedin.link from jos_linkedin where cat=10

68 (198.8410949707): SELECT fid FROM jos_deeppockets WHERE id=294745665 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294745665 AND published='1' LIMIT 1

69 (187.87384033203): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (!!!!! 4912.8532409668): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294745665 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (601.05323791504): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294745665 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (290.87066650391): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (507.11631774902): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (108.95729064941): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (159.02519226074): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (292.06275939941): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (75.817108154297): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (177.86026000977): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (!!!!! 1024.9614715576): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (59.127807617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (186.92016601562): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (463.00888061523): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294745665 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (33.140182495117): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294745665 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (122.0703125): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (75.101852416992): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (150.91896057129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

105 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

106 (97.990036010742): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294745665 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294745665 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 1219.0341949463): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

109 (123.02398681641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

110 (273.9429473877): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294745665 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (675.91667175293): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294745665 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (670.9098815918): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (772.95303344727): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 3552.1984100342): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

115 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

116 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

117 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

118 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

119 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

120 (289.2017364502): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 40805.101394653): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

123 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

124 (437.02125549316): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294745665 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294745665 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 930176.9733429): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (118.01719665527): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (68.902969360352): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (44.107437133789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (67.949295043945): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (590.08598327637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (505.92422485352): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (211.95411682129): SELECT name FROM jos_deeppockets WHERE id=213

136 (105.85784912109): SELECT name FROM jos_deeppockets WHERE id=213

137 (662.08839416504): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (512.83836364746): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

140 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

141 (!!!!! 7803.9169311523): TRUNCATE TABLE jos_trademed_module

142 (!!!!! 1286.0298156738): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294745665 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (301.83792114258): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294745665 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (421.04721069336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (149.96528625488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (135.89859008789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

147 (101.08947753906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

148 (!!!!! 1511.0969543457): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (94.175338745117): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

150 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

151 (75.101852416992): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294745665 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294745665 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (570.05882263184): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

153 (51.975250244141): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

154 (47.922134399414): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

156 (139.95170593262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294745665 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294745665 AND published='1' LIMIT 1

157 (248.90899658203): select jos_twitters.link from jos_twitters where cat=10

158 (84.161758422852): select jos_facebook.link from jos_facebook where cat=10

159 (51.975250244141): select jos_google_plus.link from jos_google_plus where cat=10

160 (84.161758422852): select jos_linkedin.link from jos_linkedin where cat=10

161 (361.91940307617): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1911.1633300781): insert into jos_banners_delta values (14615,'2025-06-20 05:15:34','216.73.216.120','view'),(14202,'2025-06-20 05:15:34','216.73.216.120','view'),(14203,'2025-06-20 05:15:34','216.73.216.120','view')

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