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Gold Nanoparticles to Deliver Powerful Radioactive Particles Directly to Tumors for Treatment

By MedImaging International staff writers
Posted on 18 Feb 2013

Researchers have demonstrated the ability to harness powerful radioactive particles and target them toward small cancerous tumors while doing negligible damage to healthy organs and tissues.

The study’s findings were published in February 2012 in the journal PLOS ONE. Typically, when radiation treatment is recommended for cancer patients, doctors are able to choose from several radiopharmaceuticals that use low-energy radiation particles, known as beta particles. For quite a while, scientists have been examining how to use alpha particles, which are radioactive particles that contain a large amount of energy, in cancer treatments. The challenges to using alpha particles, which are more than 7,000 times heavier than beta particles, include confining the powerful alpha particles in a selected location inside the body while preventing radiation from wandering to healthy organs and tissues.

“If you think of beta particles as slingshots or arrows, alpha particles would be similar to cannon balls,” said J. David Robertson, director of research at the University of Missouri (MU; Columbia, USA) research reactor and professor of chemistry in the College of Arts and Science. “Scientists have had some successes using alpha particles recently, but nothing that can battle different cancers. For example, a current study using radium-223 chloride, which emits alpha particles, has been fast-tracked by the US Food and Drug Administration because it has been shown to be effective in treating bone cancer. However, it only works for bone cancer because the element, radium, is attracted to the bone and stays there. We believe we have found a solution that will allow us to target alpha particles to other cancer sites in the body in an effective manner.”

Dr. Robertson and researchers from Oak Ridge National Laboratory (Oak Ridge, TN, USA) and the School of Medicine at the University of Tennessee (Knoxville, USA) used the element actinium, which is an element known as an alpha emitter because it generates alpha particles. As it decays, actinium creates three additional elements that produce alpha particles. Because of the strength of these particles, keeping the elements positioned at cancer sites was not possible, until the investigators designed a gold-plated nanoparticle that serves as a holding cell for the elements, keeping them in place at the cancer site.

Dr. Robertson’s nanoparticle is a layered device. At the core is the original element, actinium. The researchers then added four layers of material and then coated the nanoparticle with gold. This made the nanoparticle strong enough to hold the actinium—and the other alpha emitters that are ultimately created—long enough for any alpha particles to destroy nearby cancer cells. “Holding these alpha emitters in place is a technical challenge that researchers have been trying to overcome for 15 years,” Dr. Robertson said. “With our nanoparticle design, we are able to keep more than 80% of the element inside the nanoparticle 24 hours after it is created.”

Whereas alpha particles are very powerful, they do not travel very far, so when the nanoparticles get close to cancer cells, the alpha particles move out and destroy the cell more successfully than current radiation therapy options, according to Dr. Robertson. “Previously, basic research had established that scientists can attach antibodies onto gold nanoparticles that help drive the nanoparticles to the tumor sites in the body,” Dr. Robertson said. “Without that groundbreaking work, we would not have been able to put this puzzle together.”

The preliminary results of this research are promising. If additional studies are successful within the next few years, MU officials will request authority from the federal government to begin human drug development (referred to as the investigative new drug [IND] status). After this status has been granted, researchers may conduct human clinical trials with the potential of developing new cancer therapies.

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63 (96.797943115234): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (71.048736572266): select jos_twitters.link from jos_twitters where cat=10

65 (56.982040405273): select jos_facebook.link from jos_facebook where cat=10

66 (34.093856811523): select jos_google_plus.link from jos_google_plus where cat=10

67 (62.942504882812): select jos_linkedin.link from jos_linkedin where cat=10

68 (168.0850982666): SELECT fid FROM jos_deeppockets WHERE id=294744804 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294744804 AND published='1' LIMIT 1

69 (79.154968261719): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (244.140625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294744804 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (189.78118896484): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294744804 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (56.028366088867): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (293.01643371582): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (95.844268798828): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (109.91096496582): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (59.127807617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (59.127807617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (370.02563476562): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294744804 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (75.101852416992): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294744804 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (58.889389038086): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (832.08084106445): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (!!!!! 4178.0471801758): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (128.03077697754): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (64.849853515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (23.841857910156): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

105 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

106 (89.883804321289): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294744804 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (59.843063354492): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294744804 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

109 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

110 (97.990036010742): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294744804 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (633.00132751465): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294744804 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (550.98533630371): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (389.09912109375): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

115 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

116 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

117 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

118 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

119 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

120 (221.96769714355): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 52483.797073364): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

123 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

124 (535.01129150391): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294744804 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294744804 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 680764.91355896): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (277.04238891602): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (224.11346435547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (232.93495178223): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (225.06713867188): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (279.90341186523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (257.01522827148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (179.05235290527): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (!!!!! 1039.0281677246): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (733.1371307373): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (!!!!! 1031.1603546143): SELECT name FROM jos_deeppockets WHERE id=213

136 (50.067901611328): SELECT name FROM jos_deeppockets WHERE id=213

137 (684.97657775879): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (618.21937561035): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (!!!!! 1387.1192932129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

140 (802.04010009766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

141 (!!!!! 16167.163848877): TRUNCATE TABLE jos_trademed_module

142 (399.11270141602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294744804 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (164.03198242188): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294744804 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (526.18980407715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (186.92016601562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

147 (185.96649169922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

148 (!!!!! 2491.9509887695): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (502.8247833252): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

150 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

151 (40.054321289062): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294744804 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294744804 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (32.901763916016): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

153 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

154 (87.02278137207): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (195.02639770508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

156 (283.95652770996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744804 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744804 AND published='1' LIMIT 1

157 (56.982040405273): select jos_twitters.link from jos_twitters where cat=10

158 (33.140182495117): select jos_facebook.link from jos_facebook where cat=10

159 (29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10

160 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

161 (234.84230041504): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 6838.0832672119): insert into jos_banners_delta values (14615,'2025-06-20 13:16:18','216.73.216.120','view'),(14202,'2025-06-20 13:16:18','216.73.216.120','view'),(14203,'2025-06-20 13:16:18','216.73.216.120','view')

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