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Applications Designed to Generate Isotopes for the Development of New Radiopharmaceuticals for Cancer Treatment

By MedImaging International staff writers
Posted on 24 Jan 2013

Scientists have developed innovative ways to generate ⁹⁰Y and ¹⁷⁷Lu radionuclides. The isotopes are soon to be implemented on an industrial scale, providing more treatment opportunities to ever-increasing number of cancer patients worldwide.

Innovative applications in production technology of the ⁹⁰Y and ¹⁷⁷Lu radioisotopes will help to obtain new pharmaceuticals for cancer treatment. These applications were developed at the National Centre for Nuclear Research (NCBJ) Radioisotope Center POLATOM (Otwock, Swierk, Poland) within the framework of a three-year-long project partly financed from the Innovative Economy Program of the European Regional Development Fund. The PLN 7.8 million worth project is soon to be finished.

Polish researchers have shown that both radioisotopes (up to now only produced only at a small scale) in combination with such biologically active materials as peptides and monoclonal antibodies may form extremely effective medicines to cure some cancers. New radioisotopes will create a foundation to produce unique radiopharmaceuticals capable to effectively and safely treat cancer cases in which medicine has up to now been powerless. A new technologic production line customized for the generation of these radioisotopes has been implemented in POLATOM labs in Swierk. The pilot production is now ongoing. The first generated batches and complete analytic/technologic/validation documentation will be a basis to apply for formal registration of both radionuclides as radiopharmaceutical precursors.

“The new radioisotope preparations have been named by us Itrapol and Lutapol. They are precursors necessary to produce radiopharmaceuticals, i.e., highly specialized medicines useful in oncology. They will help to devise more effective ways to fight cancer,” explained Assoc. Prof. Renata Mikolajczak, Radioisotpe Centre POLATOM director proxy for scientific matters. “Technological solutions we have developed may be used to produce both radionuclides at an industrial scale. Increased supply of radioisotopes to the market should increase availability of the derivative cancer treatment radiopharmaceuticals, and help to disseminate new forms of internal radiotherapy that are capable to improve quality of life of several cancer patients.”

The developed technology features high specific activity (that directly influences efficacy of radiotherapy) and high chemical/radiological purity (i.e., low level of contamination with other ions/nuclides) of the ⁹⁰Y and ¹⁷⁷Lu preparations. Moreover, the applied cutting-edge applications reduce the amount of the by-produced chemical/radioactive waste.

“Production of pilot batches of Itrapol and Lutapol will be a world-class success. Our works are a perfect example of how scientific achievements may find their applications in every-day life, in this case in a particularly sensitive area related to saving human lives,” pointed out Prof. Grzegorz Wrochna, NCBJ director general. “Isotopes produced for medicine in research reactors are an exemplification of benefits brought about by ionizing radiation. Without the radiation the progress observed in medicine would not be possible.”

According to Polish Society of Endocrinology, global occurrence of endocrine tumors is on the level of 30 cases per year per one million people. Nuclear medicine is currently one of the fastest growing fields among all medical sciences. The intense interest seen in isotope diagnostics is specifically attributable to the positron emission tomography (PET) imaging. Radionuclide therapeutic technology is also developing very rapidly. Growth of demand for radiopharmaceuticals is a worldwide trend: in the United States, the growth rate is estimated for about 30% yearly, similar growth of interest is also observed in Poland.

The Polish development was awarded by the international community with a silver medal during the Innova 2012 Fair in Brussels (Belgium).

Related Links:
National Center for Nuclear Research Radioisotope Centre POLATOM

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63 (58.889389038086): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (72.002410888672): select jos_twitters.link from jos_twitters where cat=10

65 (38.862228393555): select jos_facebook.link from jos_facebook where cat=10

66 (41.007995605469): select jos_google_plus.link from jos_google_plus where cat=10

67 (37.908554077148): select jos_linkedin.link from jos_linkedin where cat=10

68 (33.140182495117): SELECT fid FROM jos_deeppockets WHERE id=294744454 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294744454 AND published='1' LIMIT 1

69 (32.901763916016): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (332.11708068848): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294744454 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (224.82872009277): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294744454 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (37.908554077148): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (64.13459777832): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (65.088272094727): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294744454 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (66.041946411133): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294744454 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (41.961669921875): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (49.829483032227): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (101.80473327637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

105 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

106 (62.942504882812): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294744454 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (48.160552978516): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294744454 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

109 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

110 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294744454 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (629.90188598633): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294744454 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (656.1279296875): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (368.11828613281): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (119.92454528809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

115 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

116 (139.95170593262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

117 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

118 (149.01161193848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

119 (190.97328186035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

120 (311.13624572754): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 23027.896881104): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (153.0647277832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

123 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

124 (607.01370239258): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294744454 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294744454 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 493324.04136658): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (92.029571533203): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (54.121017456055): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (33.855438232422): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (74.863433837891): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (553.13110351562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (401.97372436523): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (41.007995605469): SELECT name FROM jos_deeppockets WHERE id=213

136 (31.948089599609): SELECT name FROM jos_deeppockets WHERE id=213

137 (519.0372467041): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (422.95455932617): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

140 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

141 (!!!!! 17157.077789307): TRUNCATE TABLE jos_trademed_module

142 (113.96408081055): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294744454 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294744454 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (435.11390686035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

147 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

148 (!!!!! 1433.8493347168): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

150 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

151 (49.114227294922): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294744454 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294744454 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (49.829483032227): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

153 (40.054321289062): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

154 (190.01960754395): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (185.01281738281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

156 (95.844268798828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294744454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294744454 AND published='1' LIMIT 1

157 (49.114227294922): select jos_twitters.link from jos_twitters where cat=10

158 (39.100646972656): select jos_facebook.link from jos_facebook where cat=10

159 (37.193298339844): select jos_google_plus.link from jos_google_plus where cat=10

160 (38.862228393555): select jos_linkedin.link from jos_linkedin where cat=10

161 (385.99967956543): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 3508.0909729004): insert into jos_banners_delta values (14615,'2025-06-20 13:03:37','216.73.216.120','view'),(14202,'2025-06-20 13:03:37','216.73.216.120','view'),(14203,'2025-06-20 13:03:37','216.73.216.120','view')

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