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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Fat-Enclosed Nanoparticles Designed to Effectively Irradiate Brain Tumors

By MedImaging International staff writers
Posted on 01 Apr 2012

Radiation has long been the most effective way to treat deadly brain tumors called glioblastomas. Although the targeting strategy has been refined, beams of radiation still must pass through healthy brain tissue to reach the tumor, and patients can only endure small amounts before developing serious side effects. A group of scientists have created a technique to deliver nanoparticle radiation directly to the brain tumor and keep it there.

This approach doses the tumor itself with much higher levels of radiation--20 to 30 times the current dose of radiation therapy to patients--but spares a much greater area of brain tissue. The study, published March 21, 2012, in the journal Neuro-Oncology, has been successful enough in laboratory experiments that they are preparing to launch a clinical trial at the Cancer Therapy & Research Center (CTRC), according to Andrew Brenner, MD, PhD, the study’s corresponding author and a neuro-oncologist from the University of Texas (UT) Health Science Center at San Antonio (USA), who will lead the clinical trial. “We saw that we could deliver much higher doses of radiation in animal models,” Dr. Brenner said. “We were able to give it safely and we were able to completely eradicate tumors.”

The radiation comes in the form of an isotope called rhenium-186, which has a short half-life. Once positioned inside the tumor, the rhenium emits radiation that only extends out a few millimeters.

But merely placing the rhenium into a brain tumor would not work well without a way to keep it there--the miniscule particles would be captured by the bloodstream and carried away. That hurdle was resolved by a team led by nuclear medicine physician William T. Phillips, MD, and biochemist Beth A. Goins, PhD, in the department of radiology; and Ande Bao, PhD, a medical physicist, and pharmaceutical chemist in the department of otolaryngology, all of the School of Medicine at the UT Health Science Center. They encapsulated the rhenium in miniscule fat molecules, known as liposomes, about 100 nm across.

“The technology is unique,” Dr. Brenner said. “Only we can load the liposomes to these very high radioactivity levels.”

The researchers plan to begin the clinical trial by the summer of 2012.

Related Links:
University of Texas Health Science Center at San Antonio

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64 (51.975250244141): select jos_twitters.link from jos_twitters where cat=10

65 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

66 (29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10

67 (25.98762512207): select jos_linkedin.link from jos_linkedin where cat=10

68 (30.994415283203): SELECT fid FROM jos_deeppockets WHERE id=294740021 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294740021 AND published='1' LIMIT 1

69 (27.894973754883): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (226.97448730469): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294740021 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (149.01161193848): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294740021 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (36.001205444336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 1001.8348693848): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (251.77001953125): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (94.890594482422): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (316.14303588867): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (415.08674621582): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (200.03318786621): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (748.1575012207): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (147.10426330566): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (217.91458129883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (287.05596923828): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294740021 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (33.140182495117): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294740021 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (32.901763916016): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (72.002410888672): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (82.015991210938): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (195.02639770508): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (!!!!! 1344.9192047119): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (49.829483032227): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

105 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

106 (90.837478637695): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294740021 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (169.99244689941): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294740021 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 1379.9667358398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

109 (380.9928894043): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

110 (58.889389038086): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294740021 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (743.15071105957): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294740021 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (638.00811767578): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (411.03363037109): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (112.05673217773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

115 (105.14259338379): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

116 (105.85784912109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

117 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

118 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

119 (36.001205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

120 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

121 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

122 (257.96890258789): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 19932.03163147): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (489.95018005371): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294740021 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294740021 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 7174.9687194824): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (73.909759521484): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (28.848648071289): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (318.05038452148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (37.193298339844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (39.815902709961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (488.9965057373): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (392.91381835938): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (205.99365234375): SELECT name FROM jos_deeppockets WHERE id=213

138 (32.901763916016): SELECT name FROM jos_deeppockets WHERE id=213

139 (622.03407287598): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (543.83277893066): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

142 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

143 (!!!!! 9362.9360198975): TRUNCATE TABLE jos_trademed_module

144 (96.08268737793): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294740021 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (52.213668823242): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294740021 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (792.9801940918): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

149 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

150 (!!!!! 1096.0102081299): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

152 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

153 (88.930130004883): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294740021 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294740021 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (399.11270141602): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (51.021575927734): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (38.862228393555): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

158 (42.200088500977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294740021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294740021 AND published='1' LIMIT 1

159 (36.954879760742): select jos_twitters.link from jos_twitters where cat=10

160 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

161 (34.093856811523): select jos_google_plus.link from jos_google_plus where cat=10

162 (31.948089599609): select jos_linkedin.link from jos_linkedin where cat=10

163 (211.95411682129): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1102.9243469238): insert into jos_banners_delta values (14615,'2025-06-21 02:59:40','216.73.216.120','view'),(14202,'2025-06-21 02:59:40','216.73.216.120','view'),(14203,'2025-06-21 02:59:40','216.73.216.120','view')

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