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Lifelong Brain-Stimulating Practices Leads to Lower Alzheimer’s Protein Levels

By MedImaging International staff writers
Posted on 01 Feb 2012
Image: PET scans reveal amyloid plaques, which appear as warm colors such as red and orange. The middle scan is from a person with no symptoms of cognitive problems, but with evident levels of amyloid plaque in the brain (Photo courtesy of Susan Landau and William Jagust).
Image: PET scans reveal amyloid plaques, which appear as warm colors such as red and orange. The middle scan is from a person with no symptoms of cognitive problems, but with evident levels of amyloid plaque in the brain (Photo courtesy of Susan Landau and William Jagust).
Neuroimaging scans have revealed that individuals with no symptoms of Alzheimer’s who engaged in cognitively stimulating activities throughout their lives had fewer deposits of beta-amyloid, a destructive protein that is major characteristic of the disease.

Whereas earlier studies have implied that engaging in mentally stimulating activities--such as reading, writing, and playing games--may help stave off Alzheimer’s disease later in life, this new study identifies the biologic target at play. This finding could guide future research into effective prevention strategies.

“These findings point to a new way of thinking about how cognitive engagement throughout life affects the brain,” said study lead investigator Dr. William Jagust, a professor with joint appointments at University of California, Berkeley’s (USA) Helen Wills Neuroscience Institute, the School of Public Health and Lawrence Berkeley National Laboratory. “Rather than simply providing resistance to Alzheimer’s, brain-stimulating activities may affect a primary pathological process in the disease. This suggests that cognitive therapies could have significant disease-modifying treatment benefits if applied early enough, before symptoms appear.”

The new study, published January 23, 2012, in the journal Archives of Neurology, places the focus on amyloid--protein fibers folded into tangled plaques that accumulate in the brain. Beta-amyloid is considered the top culprit in the pathology of Alzheimer’s disease; therefore, finding a way to reduce its development has become a major new direction of research.

The researchers noted that the buildup of amyloid can also be influenced by genes and aging-- one-third of people age 60 and over have some amyloid deposits in their brain--but how much reading and writing one does is under each individual’s control. “This is the first time cognitive activity level has been related to amyloid buildup in the brain,” said study lead author Dr. Susan Landau, research scientist at the Helen Wills Neuroscience Institute and the Berkeley Lab. “Amyloid probably starts accumulating many years before symptoms appear. So it’s possible that by the time you have symptoms of Alzheimer’s, like memory problems, there is little that can be done to stop disease progression. The time for intervention may be much sooner, which is why we’re trying to identify whether lifestyle factors might be related to the earliest possible changes.”

The researchers asked 65 healthy, cognitively normal adults aged 60 and over (median age was 76) to rate how frequently they participated in such mentally stilmulating activities as going to the library, reading books or newspapers, and writing letters or email. The questions focused on various points in life from age six to the present.

The participants took part in extensive neuropsychologic testing to evaluate memory and other cognitive functions, and received positron emission tomography (PET) scans at the Berkeley Lab using a new tracer called Pittsburgh compound B that was developed to visualize amyloid. The results of the brain scans of healthy older individuals with various levels of lifetime cognitive activity were compared with those of 10 patients diagnosed with Alzheimer’s disease and 11 healthy individuals in their 20s.
The researchers discovered a significant association between higher levels of cognitive activity over a lifetime and lower levels of beta-amyloid in the PET scans. They analyzed the impact of other factors such as memory function, physical activity, self-rated memory ability, level of education and gender, and found that lifelong cognitive engagement was independently linked to amyloid deposition.

Significantly, the researchers did not find a strong connection between amyloid deposition and levels of current cognitive activity alone. “What our data suggest is that a whole lifetime of engaging in these activities has a bigger effect than being cognitively active just in older age,” said Dr. Landau.

The researchers stressed that the study does not contradict the benefits of jolting brain activity in later years. “There is no downside to cognitive activity. It can only be beneficial, even if for reasons other than reducing amyloid in the brain, including social stimulation and empowerment,” said Dr. Jagust. “And actually, cognitive activity late in life may well turn out to be beneficial for reducing amyloid. We just haven’t found that connection yet.”

Other researchers involved in the study were from the University California (UC) San Francisco’s (USA) Memory and Aging Center and department of neurology, and Rush University Medical Center’s Alzheimer’s Disease Center (Chicago, IL, USA).

Related Links:

University of California, Berkeley
University California, San Francisco
Rush University Medical Center’s Alzheimer’s Disease Center


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87 (571.96617126465): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294739107 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
88 (34.093856811523): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294739107 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
89 (31.948089599609): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
90 (422.00088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1
91 (400.06637573242): SELECT show_live FROM jos_com_show_setting LIMIT 1
92 (145.91217041016): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (87.02278137207): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (763.89312744141): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (190.97328186035): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (168.0850982666): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (140.90538024902): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (829.93507385254): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (200.98686218262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
105 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
106 (102.04315185547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739107 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (82.015991210938): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739107 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (746.9654083252): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
109 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
110 (100.13580322266): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294739107 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (454.90264892578): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294739107 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (!!!!! 1115.083694458): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (528.81240844727): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (303.98368835449): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
115 (508.06999206543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
116 (543.83277893066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
117 (380.9928894043): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
118 (!!!!! 1410.0074768066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
119 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
120 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
121 (176.19132995605): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
122 (509.02366638184): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
123 (!!!!! 52684.06867981): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
124 (!!!!! 3690.0043487549): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294739107 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294739107 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (386.95335388184): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (124.21607971191): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (180.95970153809): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
128 (152.1110534668): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (193.11904907227): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
130 (112.05673217773): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (183.10546875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
132 (162.83988952637): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (178.81393432617): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
134 (113.96408081055): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (329.01763916016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
136 (238.18016052246): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (160.93254089355): SELECT name FROM jos_deeppockets WHERE id=213
138 (33.140182495117): SELECT name FROM jos_deeppockets WHERE id=213
139 (524.99771118164): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
140 (499.96376037598): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (339.98489379883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
142 (52.213668823242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
143 (!!!!! 27765.989303589): TRUNCATE TABLE jos_trademed_module
144 (!!!!! 1924.0379333496): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739107 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
145 (118.01719665527): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294739107 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (!!!!! 1189.9471282959): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147 (311.85150146484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (396.9669342041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
149 (606.06002807617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
150 (!!!!! 3849.983215332): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
151 (110.86463928223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
152 (68.187713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
153 (384.09233093262): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294739107 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294739107 AND type='deeppockets_item' AND published='1' LIMIT 1
154 (59.127807617188): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)
155 (44.107437133789): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)
156 (40.054321289062): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
157 (!!!!! 1414.0605926514): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
158 (!!!!! 4880.9051513672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294739107 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294739107 AND published='1' LIMIT 1
159 (73.909759521484): select jos_twitters.link from jos_twitters where cat=10
160 (40.054321289062): select jos_facebook.link from jos_facebook where cat=10
161 (38.14697265625): select jos_google_plus.link from jos_google_plus where cat=10
162 (38.862228393555): select jos_linkedin.link from jos_linkedin where cat=10
163 (347.13745117188): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)
164 (!!!!! 1361.8469238281): insert into jos_banners_delta values (14615,'2025-06-21 03:15:00','216.73.216.120','view'),(14202,'2025-06-21 03:15:00','216.73.216.120','view'),(14203,'2025-06-21 03:15:00','216.73.216.120','view')