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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Research Reveals PET Effectively Identifies Dementia

By MedImaging International staff writers
Posted on 18 Jan 2012

In a new report of imaging studies covering more than 10 years, scientists revealed that a positron emission tomography (PET) imaging technique safely and effectively identifies dementia, including the most typical and debilitating form affecting older individuals, Alzheimer’s disease.

The study’s findings were published in the January 2012 issue of the Journal of Nuclear Medicine. Researchers reviewed many PET studies to assess a molecular imaging technique that combines PET, which provides functional images of biologic mechanisms, with an injected biomarker called 18F-FDG to target major areas of metabolic decrease in the brain indicating dementia. Having physiologic evidence of neurodegenerative disease by imaging patients with PET could provide clinicians with the data they need to make more accurate diagnoses earlier than ever before.

“The new data support the role of 18F-FDG PET as an effective addition to other diagnostic methods used to assess patients with symptoms of dementia,” commented Nicolaas Bohnen, MD, PhD, lead author of the study and professor of radiology and neurology at the University of Michigan (Ann Arbor, MI, USA). “The review also identified new literature showing the benefit of this imaging technique for not only helping to diagnose dementia but also for improving physician confidence when diagnosing a patient with dementia. This process can be difficult for physicians, especially when evaluating younger patients or those who have subtle signs of disease.”

Dementia is not a specific disease but a pattern of symptoms characterized by a loss of cognitive ability. These disorders can be caused by injury or progressive disease affecting regions of the brain that regulate attention, memory, language, and mobility. Whereas Alzheimer’s is most typically associated with progressive memory impairment, dementia with Lewy bodies, another form of the disease, can be associated with symptoms of Parkinson’s and prominent hallucinations, while another disorder, called frontotemporal dementia, can be seen in patients showing abnormal personality changes and problems in communicating and relating. Physicians can use FDG-PET with high accuracy to not only help diagnose dementia but also differentiate between the individual disorders. The role molecular imaging plays in the diagnosis of dementia has expanded enough that the official principles physicians use to diagnose patients now includes evidence from molecular imaging studies.

“For the first time, imaging biomarkers of Alzheimer’s disease are included in the newly revised clinical diagnostic criteria for the disease,” said Dr. Bohnen. “This is a major shift in disease definition, as previously an Alzheimer’s diagnosis was based mainly on a process of evaluating patients to exclude possible trauma, hemorrhage, tumor, or metabolic disorder. Now it is becoming a process of inclusion based on biomarker evidence from molecular imaging.”

The PET biomarker 18F-FDG comprises a radionuclide combined with fluorodeoxyglucose (FDG), which mimics glucose in the body. Cells metabolize FDG as fuel, and the variation in this uptake by cells throughout the body can then be imaged to identify a range of abnormalities. In the instance of dementia, marked reductions in the metabolism of different lobes of the cerebral cortex can confirm a disorder. Physicians can differentiate Alzheimer’s disease from other dementias, depending on the specific cortices affected.

This study, according to the investigators, represents the newest and most significant evidence of FDG-PET’s effectiveness for the assessment of patients with suspected dementia. The goal of the study was to replace earlier retrospective reviews that were performed as the technique was just emerging and that suggested methodologic improvements. The new review includes studies with better methodology, including validation of diagnoses with autopsy, more expansive recruitment of subjects, and use of multicenter studies. After reviewing 11 studies that occurred since the year 2000 and that met more stringent study review standards, researchers concluded that 18F-FDG is very effective for detecting the presence and type of dementia.

“Using 18F-FDG PET in the evaluation of patients with dementia can improve diagnostic accuracy and lead to earlier treatment and better patient care,” said Dr. Bohnen. “The earlier we make a diagnosis, the more we can alleviate uncertainty and suffering for patients and their families."

The biomarker 18F-FDG is among a range of imaging agents being studied for its effectiveness in Alzheimer’s imaging. As dementia treatments become available for clinical use, PET should play a significant role in not only the diagnosis of these diseases, but also the assessment and monitoring of future therapies.

According to the World Health Organization (Geneva, Switzerland), an estimated 18 million people worldwide are currently living with Alzheimer disease. That number is projected to nearly double by 2025.

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56 (872.85041809082): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738913 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

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58 (!!!!! 7709.0263366699): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

59 (!!!!! 6465.9118652344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

60 (!!!!! 3246.0689544678): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

61 (956.05850219727): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (504.97055053711): SELECT fid FROM jos_deeppockets WHERE id=294738913 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294738913 AND published='1' LIMIT 1

63 (!!!!! 4662.9905700684): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (!!!!! 8846.0445404053): select jos_twitters.link from jos_twitters where cat=10

65 (!!!!! 2181.0531616211): select jos_facebook.link from jos_facebook where cat=10

66 (!!!!! 4729.0325164795): select jos_google_plus.link from jos_google_plus where cat=10

67 (715.01731872559): select jos_linkedin.link from jos_linkedin where cat=10

68 (!!!!! 1495.1229095459): SELECT fid FROM jos_deeppockets WHERE id=294738913 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294738913 AND published='1' LIMIT 1

69 (305.17578125): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (560.04524230957): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294738913 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 1744.9855804443): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294738913 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 1656.0554504395): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 2437.1147155762): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (!!!!! 1513.0043029785): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (527.14347839355): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (494.00329589844): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (!!!!! 3005.0277709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (459.90943908691): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (!!!!! 1272.9167938232): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (669.95620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (520.94459533691): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (79.870223999023): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (!!!!! 1048.0880737305): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (545.97854614258): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (!!!!! 2934.9327087402): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (249.14741516113): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 2048.0155944824): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294738913 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (!!!!! 2288.818359375): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294738913 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (328.06396484375): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 3471.851348877): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (!!!!! 4013.0615234375): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (956.05850219727): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (799.17907714844): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (570.05882263184): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (!!!!! 1319.8852539062): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (!!!!! 3617.0482635498): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (580.0724029541): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (903.12957763672): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (!!!!! 2016.0675048828): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (319.9577331543): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (324.96452331543): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (291.10908508301): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (180.00602722168): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (308.03680419922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

105 (265.12145996094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

106 (!!!!! 1528.9783477783): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738913 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (134.94491577148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738913 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (573.15826416016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

109 (355.95893859863): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

110 (!!!!! 12490.034103394): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294738913 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (961.0652923584): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294738913 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 3462.0761871338): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 2823.1143951416): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 2094.9840545654): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

115 (!!!!! 3422.0218658447): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

116 (!!!!! 1760.0059509277): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

117 (!!!!! 2966.8807983398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

118 (689.98336791992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

119 (525.95138549805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

120 (!!!!! 1945.972442627): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

121 (!!!!! 2809.0476989746): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

122 (!!!!! 1420.9747314453): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 191690.92178345): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 2114.0575408936): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294738913 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294738913 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 1305.8185577393): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 1630.0678253174): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 3679.9907684326): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (!!!!! 1236.2003326416): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (398.87428283691): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (881.91032409668): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (!!!!! 1445.0550079346): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (939.84603881836): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (!!!!! 1688.0035400391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (431.06079101562): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 7437.9444122314): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (!!!!! 12196.063995361): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (!!!!! 7798.9101409912): SELECT name FROM jos_deeppockets WHERE id=213

138 (!!!!! 7998.9433288574): SELECT name FROM jos_deeppockets WHERE id=213

139 (!!!!! 1449.1081237793): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (!!!!! 4225.9693145752): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 19999.027252197): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

142 (!!!!! 4698.0381011963): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

143 (!!!!! 19791.126251221): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 6873.8460540771): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738913 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (!!!!! 8085.0124359131): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738913 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 7658.9584350586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (!!!!! 6568.9086914062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 8996.9635009766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

149 (!!!!! 7947.9217529297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

150 (!!!!! 7461.0710144043): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 5337.9535675049): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

152 (!!!!! 9994.9836730957): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

153 (!!!!! 7692.0986175537): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294738913 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294738913 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (!!!!! 7908.821105957): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (!!!!! 8200.1686096191): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (!!!!! 5568.9811706543): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 6150.9609222412): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

158 (708.10317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738913 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738913 AND published='1' LIMIT 1

159 (!!!!! 1212.8353118896): select jos_twitters.link from jos_twitters where cat=10

160 (216.00723266602): select jos_facebook.link from jos_facebook where cat=10

161 (946.044921875): select jos_google_plus.link from jos_google_plus where cat=10

162 (!!!!! 2407.0739746094): select jos_linkedin.link from jos_linkedin where cat=10

163 (796.07963562012): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1466.0358428955): insert into jos_banners_delta values (14615,'2025-06-21 04:00:09','216.73.216.120','view'),(14202,'2025-06-21 04:00:09','216.73.216.120','view'),(14203,'2025-06-21 04:00:09','216.73.216.120','view')

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