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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Imaging Technologies Evaluate Effectiveness of Heart Drug

By MedImaging International staff writers
Posted on 28 Sep 2011

Researchers for the first time have used several imaging techniques to prove the efficacy of a promising new treatment for atherosclerosis.

Using positron-emission tomography (PET)/computed tomography (CT) and magnetic resonance imaging (MRI), the research team showed that dalcetrapib, an innovative treatment for atherosclerosis, prevented the progression of disease, and reduced vascular inflammation over 24 months.

The study’s findings were published in the September 12, 2011, issue of the Lancet. The dal-PLAQUE (dalcetrapib’s effects on vascular function [dal-VESSEL] and on atherosclerotic disease progression [dal-PLAQUE]) study is the longest placebo-controlled, active-drug MRI study to date, and the first to use a variety of noninvasive imaging techniques to visualize arterial plaque. In this phase IIB, double-blind, multicenter trial, Mount Sinai School of Medicine (New York, NY, USA) researchers assessed 130 study participants with atherosclerosis who were randomized to receive dalcetrapib or placebo for 24 months. To determine the efficacy of dalcetrapib, the team used MRI to analyze plaque progression in the arterial wall and PET/CT to assess arterial inflammation. The images revealed that dalcetrapib considerably reduced atherosclerotic disease progression and inflammation.

“This milestone study shows that MRI and PET/CT are highly useful in assessing the safety and efficacy of dalcetrapib, and that this novel therapy may address a significantly unmet need in cardiovascular disease,” said Zahi A. Fayad, PhD, a professor of radiology and medicine in the division of cardiology, and the director of the Translational and Molecular Imaging Institute at Mount Sinai School of Medicine, and lead author on the study. “We are excited about the results obtained in this trial, which could have a great impact on the treatment of patients with cardiovascular disease.”

Lowering of the so-called bad cholesterol (low-density lipoprotein) through statin use, is a highly effective technique of improving cardiovascular outcome in a wide range of patients. However, despite optimal use, significant risk remains. Dalcetrapib is part of a class of drugs called cholesteryl ester transfer protein inhibitors that raise high-density lipoprotein (HDL) commonly known as “good” cholesterol. Research has shown that raising HDL cholesterol may reduce coronary artery disease risk. In the dal-PLAQUE study, patients who received dalcetrapib saw a 31% increase in HDL cholesterol levels, as examined through MRI scanning. The PET/CT scans showed that inflammation levels in the carotid artery of patients taking dalcetrapib were significantly reduced yet stayed the same in the placebo group.

“Considering the concerns surrounding this class of drugs, MRI and PET/CT imaging are valuable biomarkers for assessing safety and efficacy,” said Dr. Fayad. “The first drug in this class, torcetrapib, effectively increased HDL cholesterol but caused a significant increase in mortality due to vascular inflammation. Through noninvasive imaging, we were able to determine that the inflammation associated with torcetrapib was not found in dalcetrapib. The success of this trial indicates that noninvasive imaging may be a critical tool for evaluating other investigational treatments for heart disease as well.”

Mount Sinai is establishing a center that will use state of the art imaging technology to help treat and prevent atherosclerosis, heart attack, and heart failure. In collaboration with the Mount Sinai Cardiovascular Institute and Mount Sinai Heart, the new Translational and Molecular Imaging Institute will continue to innovate, validate, and translate new tools for the improvements of patients care.

“Cardiovascular disease impacts millions of people, and costs billions of dollars each year in the United States alone,” said Valentin Fuster, MD, PhD, director of Mount Sinai Heart, the Zena and Michael A. Wiener Cardiovascular Institute, and the Marie-Josee and Henry R. Kravis Center for Cardiovascular Health at The Mount Sinai Medical Center. “As demonstrated in the dal-PLAQUE study, Dr. Fayad has brought Mount Sinai to the forefront of using noninvasive imaging to help study, prevent, and treat heart disease. We look forward to using MRI and PET/CT in future clinical trials.”

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58 (!!!!! 2098.0834960938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

59 (!!!!! 9092.0925140381): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

60 (724.07722473145): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

61 (!!!!! 7493.9727783203): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (569.10514831543): SELECT fid FROM jos_deeppockets WHERE id=294737324 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294737324 AND published='1' LIMIT 1

63 (337.83912658691): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (52.928924560547): select jos_twitters.link from jos_twitters where cat=10

65 (35.04753112793): select jos_facebook.link from jos_facebook where cat=10

66 (36.001205444336): select jos_google_plus.link from jos_google_plus where cat=10

67 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

68 (54.836273193359): SELECT fid FROM jos_deeppockets WHERE id=294737324 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294737324 AND published='1' LIMIT 1

69 (33.140182495117): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (300.16899108887): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294737324 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (368.11828613281): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294737324 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (44.822692871094): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (375.03242492676): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (735.99815368652): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 2449.0356445312): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294737324 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (63.896179199219): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294737324 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (42.915344238281): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (68.902969360352): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (65.088272094727): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

105 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

106 (!!!!! 1393.0797576904): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737324 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737324 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (260.82992553711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

109 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

110 (!!!!! 2588.9873504639): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737324 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 3183.126449585): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737324 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 1235.9619140625): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (641.82281494141): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (617.98095703125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

115 (!!!!! 1484.1556549072): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

116 (118.97087097168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

117 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

118 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

119 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

120 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

121 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

122 (292.06275939941): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 37831.06803894): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 5522.9663848877): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294737324 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294737324 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 2216.100692749): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (333.07075500488): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (159.97886657715): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (153.0647277832): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (72.002410888672): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (54.121017456055): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (716.9246673584): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (774.86038208008): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (206.94732666016): SELECT name FROM jos_deeppockets WHERE id=213

138 (34.093856811523): SELECT name FROM jos_deeppockets WHERE id=213

139 (555.99212646484): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (446.08116149902): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 3271.8181610107): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

142 (283.00285339355): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

143 (!!!!! 16517.877578735): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 5351.0665893555): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737324 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (974.89356994629): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737324 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 1419.0673828125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 1538.0382537842): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

149 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

150 (!!!!! 1583.0993652344): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (967.02575683594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

152 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

153 (!!!!! 5233.0493927002): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294737324 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294737324 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (46.968460083008): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (32.901763916016): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (582.93342590332): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

158 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737324 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737324 AND published='1' LIMIT 1

159 (!!!!! 6730.0796508789): select jos_twitters.link from jos_twitters where cat=10

160 (!!!!! 7930.9940338135): select jos_facebook.link from jos_facebook where cat=10

161 (!!!!! 7943.1533813477): select jos_google_plus.link from jos_google_plus where cat=10

162 (!!!!! 7940.0539398193): select jos_linkedin.link from jos_linkedin where cat=10

163 (!!!!! 3849.0295410156): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1056.9095611572): insert into jos_banners_delta values (14615,'2025-06-22 02:20:35','216.73.216.120','view'),(14202,'2025-06-22 02:20:35','216.73.216.120','view'),(14203,'2025-06-22 02:20:35','216.73.216.120','view')

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