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Alzheimer’s Disease Imaging Guidelines Supported by New Research

By MedImaging International staff writers
Posted on 25 Aug 2011

Two new studies provide insights into the potential of positron emission tomography (PET) imaging to differentiate between types of dementia and to identify pharmaceutical agents to slow the progress of dementia.

With proposed US National Institute on Aging (NIA; Bethesda, MD, USA) and the Alzheimer’s Association (Chicago, IL, USA) guidelines for detecting Alzheimer’s-related brain changes expected in September 2011, these articles give a preview of what may be to come. The studies were both published in the August 2011 issue of the Journal of Nuclear Medicine (JNM).

Earlier in 2011, the NIA and the Alzheimer’s Association released new criteria and guidelines for the diagnosis of Alzheimer’s disease (AD). The new proposed guidelines available the fall of 2011 will offer additional information regarding the development of tests to measure biologic changes in the brain, blood, or spinal fluid to diagnose AD at an earlier stage.

Earlier diagnosis of AD is the focus of the new study, conducted by investigators from the department of medicine, the University of Melbourne (Parkville, Victoria, Australia) in which researchers compared cortical amyloid deposition using ¹⁸F-florbetaben and PET in 109 controls and study participants with mild cognitive impairment (MCI), frontotemporal lobar degeneration, dementia with Lewy bodies, vascular dementia, Parkinson’s disease, and AD. The study’s findings revealed that ¹⁸F-florbetaben performs with the same high accuracy as previously reported with ¹¹C-Pittsburgh compound B--the most specific and widely used amyloid-imaging agent--for differentiating between specific types of neurodegenerative dementia, particularly for diagnosis of AD from frontotemporal dementia.

“The difference between ¹¹C-Pittsburgh compound B and ¹⁸F-florbetaben is that the ¹⁸F-florbetaben has a longer half-life and is more affordable, making it appropriate for clinical use,” said Christopher Rowe, MD, FRACP, one of the authors of the study. “This distinction profoundly affects treatment and prognosis and has genetic implications for the family.”

In addition to detecting AD earlier, molecular imaging can also be used in clinical trials to help develop pharmaceuticals to prevent or delay the onset of dementia. This is particularly of significance to patients with MCI who have yet to develop Alzheimer’s disease.

“We urgently need tools for conducting drug trials for MCI more efficiently,” noted Karl Herholz, MD, lead author of the study, from the University of Manchester (UK). He continued, “Clinical outcome parameters show large variability and little sensitivity to progression at that stage, making these trials extremely costly and cumbersome. By using imaging biomarkers as primary outcome parameters, clinical trials can be performed with smaller sample sizes or shorter trial duration without loss of study power.”

The study evaluated a predefined quantitative measure--a PET score--that was extracted automatically from ¹⁸F-FDG PET scans using a sample of controls, patients with MCI, and patients with Alzheimer’s disease. The PET scores provided a much higher test-retest reliability than standard neuropsychologic test scores (Alzheimer’s Disease Assessment Scale-Cognitive and Mini-Mental State Examination) and superior strength for measuring progression, as well as a valid measurement of cognitive impairment. As such, the PET scores can be considered a valid imaging biomarker to monitor the progression of MCI to Alzheimer's disease.

“Prevention of dementia by drugs applied at MCI stage would greatly improve quality of life for patients and reduce costs of dementia care and treatment. Thus, development of such drugs and efficient tools for testing them are extremely important,” concluded Dr. Herholz.

AD is an irreversible, progressive brain disease that slowly destroys memory and thinking skills, and ultimately, the ability to carry out the simplest tasks of daily living. Although treatment can slow the progression of the disease and help manage its symptoms, there is no cure for Alzheimer’s disease.

Related Links:
University of Melbourne
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59 (94.175338745117): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

60 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

61 (77.962875366211): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (518.798828125): SELECT fid FROM jos_deeppockets WHERE id=294736763 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294736763 AND published='1' LIMIT 1

63 (267.02880859375): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (54.121017456055): select jos_twitters.link from jos_twitters where cat=10

65 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

66 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

67 (28.133392333984): select jos_linkedin.link from jos_linkedin where cat=10

68 (31.232833862305): SELECT fid FROM jos_deeppockets WHERE id=294736763 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294736763 AND published='1' LIMIT 1

69 (35.04753112793): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (355.00526428223): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294736763 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (217.19932556152): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294736763 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (36.001205444336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (45.061111450195): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294736763 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (28.848648071289): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294736763 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (33.140182495117): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (55.789947509766): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

105 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

106 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294736763 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (45.7763671875): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294736763 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

109 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

110 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294736763 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (535.96496582031): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294736763 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (576.97296142578): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (396.0132598877): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

115 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

116 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

117 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

118 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

119 (35.04753112793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

120 (40.769577026367): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

121 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

122 (277.99606323242): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 19300.937652588): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (626.0871887207): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294736763 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294736763 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 7337.8086090088): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (112.05673217773): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (281.81076049805): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (27.179718017578): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (437.02125549316): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (320.1961517334): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (253.91578674316): SELECT name FROM jos_deeppockets WHERE id=213

138 (33.855438232422): SELECT name FROM jos_deeppockets WHERE id=213

139 (638.00811767578): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (479.93659973145): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

142 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

143 (!!!!! 8598.804473877): TRUNCATE TABLE jos_trademed_module

144 (108.95729064941): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294736763 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (72.956085205078): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294736763 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (802.04010009766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

149 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

150 (!!!!! 1119.1368103027): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

152 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

153 (33.140182495117): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294736763 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294736763 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (28.133392333984): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (26.941299438477): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (52.928924560547): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

158 (!!!!! 3843.0690765381): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736763 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736763 AND published='1' LIMIT 1

159 (!!!!! 1094.8181152344): select jos_twitters.link from jos_twitters where cat=10

160 (44.822692871094): select jos_facebook.link from jos_facebook where cat=10

161 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

162 (28.133392333984): select jos_linkedin.link from jos_linkedin where cat=10

163 (262.02201843262): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1129.8656463623): insert into jos_banners_delta values (14615,'2025-06-22 01:48:51','216.73.216.120','view'),(14202,'2025-06-22 01:48:51','216.73.216.120','view'),(14203,'2025-06-22 01:48:51','216.73.216.120','view')

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