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Molecular Imaging for Early Alzheimer's Detection May Be Available Within a Year

By MedImaging International staff writers
Posted on 22 Jun 2011

Researchers worldwide are advancing positron emission tomography (PET) as an effective method of early detection for Alzheimer's disease (AD), a currently incurable and deadly neurologic disorder. Three studies are providing new insights into the development of AD while creating opportunities for future clinical screening and treatments.

According to the World Health Organization (WHO; Geneva, Switzerland), an estimated 18 million people worldwide are currently living with AD disease--a number projected to almost double by 2025. "The aging population around the world is escalating exponentially. From a macro perspective, amyloid imaging with PET scans can help to ascertain the likelihood that individuals will deteriorate cognitively within a few years, thereby enabling more efficient channeling of healthcare resources," said Kevin Ong, MD, lead author of a study presented at SNM's 58th annual meeting, held June 4-8, 2011, in San Antonio (TX, USA) and a research scientist at Austin Hospital (Heidelberg, VIC, Australia). "From a micro perspective, planning and lifestyle modifications are possible for individuals who seek screening for Alzheimer's disease."

Molecular imaging of AD is focused on detecting and analyzing the formation of a naturally occurring protein in the brain called beta-amyloid, which researchers now say is directly involved in the pathology of AD. "It turns out that increased amyloid is bad for cognition even in the healthy elderly," stated Michael Devous, Sr., PhD, director of neuroimaging for the Alzheimer's Disease Center at University of Texas (UT) Southwestern Medical Center (Dallas, TX, USA). "If you look at working memory, processing speed or fluent reasoning, three critical general domains of cognition, the more amyloid you have the worse your performance, and that's after correcting for age."

Not only is this significant for imaging the disease, but it may also prove to be the key to amyloid-associated therapies and vaccines. Investigators caution that the early stages of the disease can precede symptoms of dementia as much as a decade or more. Imaging patients when they first show signs of mild cognitive impairment could be crucial to determining their risk of future disease.

"For individuals who have already developed a measurable memory decline, a positive scan for amyloid is the most accurate predictor of progression to Alzheimer's disease," said Christopher Rowe, MD, a lead investigator for the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging and professor of nuclear medicine at Austin Hospital. "Amyloid imaging with PET scans is expected to be widely available soon for clinical practice. It will be an important new tool in the assessment of cognitive decline."

Beta-amyloid accumulates as neurotoxic plaque in individuals preceding the onset of AD, and as a result, extensive neural tissues that control major mental and physical functioning--including memory, language, and motor function--are decimated. In time, the disease becomes debilitating and has a devastating impact on individuals' quality of life.

Three ongoing studies presented at this year's meeting involve several years of research based on hundreds of participants ranging widely in age, cognitive ability, and stage of disease. Results of these studies show that amyloid plaques build up very slowly, by an estimated two to three percent per year, and that they are often already present in healthy older individuals--12% of those in their 60s, 30% of those in their 70s, and 55% in those over the age of 80. In one study, about 25% of subjects over the age of 60 had amyloid plaques. The presence of significant amyloid buildup is linked to faster memory decline and brain atrophy.

One of the major questions in Alzheimer's imaging has been which imaging agent is best for amyloid plaque screening. Several studies have been conducted using ¹¹C Pittsburgh compound-B (¹¹C-PIB), a PET imaging agent that binds to beta-amyloid in neural tissues, but two of the current studies are gauging the benefit of using F-18 labeled tracers (F-18 Florbetaben and F-18 Florbetapir), designed for routine clinical use. Both F-18 Florbetaben and F-18 Florbetapir are proving to be good predictors of progression to Alzheimer's disease, and F-18 amyloid imaging agents are the likeliest agents to move forward into clinical practice in the near future.

Researchers estimate that amyloid imaging agents will be available for clinical use in fewer than 12 months. These and additional studies will continue to amass data about the development of Alzheimer's disease, and potential treatments could eventually stop and perhaps even prevent or reverse damage in the brain caused by AD.

Related Links:
Austin Hospital
University of Texas Southwestern Medical Center
WHO

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58 (!!!!! 6333.1127166748): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

59 (!!!!! 17323.017120361): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

60 (580.0724029541): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

61 (!!!!! 2355.0987243652): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (710.01052856445): SELECT fid FROM jos_deeppockets WHERE id=294735690 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294735690 AND published='1' LIMIT 1

63 (!!!!! 6790.1611328125): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (!!!!! 4412.1742248535): select jos_twitters.link from jos_twitters where cat=10

65 (247.95532226562): select jos_facebook.link from jos_facebook where cat=10

66 (648.02169799805): select jos_google_plus.link from jos_google_plus where cat=10

67 (118.97087097168): select jos_linkedin.link from jos_linkedin where cat=10

68 (159.97886657715): SELECT fid FROM jos_deeppockets WHERE id=294735690 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294735690 AND published='1' LIMIT 1

69 (924.11041259766): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (571.01249694824): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294735690 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 1176.8341064453): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294735690 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 1315.1168823242): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 1701.831817627): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (167.1314239502): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (729.08401489258): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (45.7763671875): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (370.97930908203): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (99.897384643555): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (700.95062255859): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (303.03001403809): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (396.9669342041): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (308.99047851562): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (137.0906829834): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 1784.086227417): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294735690 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (507.11631774902): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294735690 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (210.04676818848): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 4180.908203125): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (215.05355834961): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (632.04765319824): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (113.96408081055): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (190.01960754395): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (138.99803161621): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (776.05247497559): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (301.12266540527): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (294.20852661133): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1781.9404602051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

105 (760.07843017578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

106 (299.21531677246): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294735690 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (633.00132751465): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294735690 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 5412.1017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

109 (566.00570678711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

110 (674.00932312012): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294735690 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 2177.9537200928): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294735690 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (601.05323791504): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (325.91819763184): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

115 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

116 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

117 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

118 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

119 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

120 (45.7763671875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

121 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

122 (375.98609924316): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 54432.86895752): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 1429.0809631348): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294735690 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294735690 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (160.93254089355): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (145.91217041016): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (128.03077697754): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (!!!!! 1276.0162353516): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (125.16975402832): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (722.88513183594): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (!!!!! 1044.9886322021): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (131.84547424316): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (232.21969604492): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (294.92378234863): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (773.90670776367): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (660.89630126953): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (61.988830566406): SELECT name FROM jos_deeppockets WHERE id=213

138 (41.007995605469): SELECT name FROM jos_deeppockets WHERE id=213

139 (!!!!! 1150.1312255859): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (824.92828369141): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 1374.9599456787): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

142 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

143 (!!!!! 29951.095581055): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 3613.9488220215): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294735690 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (167.1314239502): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294735690 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (597.00012207031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

149 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

150 (!!!!! 1622.9152679443): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (133.99124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

152 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

153 (56.028366088867): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294735690 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294735690 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (42.915344238281): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (37.908554077148): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (46.968460083008): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (188.11225891113): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

158 (120.16296386719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735690 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735690 AND published='1' LIMIT 1

159 (55.074691772461): select jos_twitters.link from jos_twitters where cat=10

160 (38.14697265625): select jos_facebook.link from jos_facebook where cat=10

161 (37.908554077148): select jos_google_plus.link from jos_google_plus where cat=10

162 (69.856643676758): select jos_linkedin.link from jos_linkedin where cat=10

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