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Clinical Research Supports Promising Outlook for Low-Dose Molecular Breast Imaging

By MedImaging International staff writers
Posted on 01 Jun 2011

New research revealed that low-dose molecular breast imaging (MBI) has a promising future as seen by the most recent clinical evidence.

The findings were presented in April 2011 at the US National Institutes of Health (NIH; Bethesda, MD, USA). Dr. Marcela Bohm-Velez and her colleagues from Weinstein Imaging Associates (Pittsburgh, PA, USA) shared preliminary findings from a prospective study on low-dose MBI, specifically breast-specific gamma imaging (BSGI), at the SNM (Society of Nuclear Medicine) Breast Cancer Imaging: State of the Art 2011. Their results suggest it may be possible to reduce the radiation dose patients receive from a BSGI procedure by up to 60%.

The tracer used in this procedure, technetium Tc99m sestamibi (MIBI), has typically been used in cardiac studies for a long time and was cleared by the US Food and Drug Administration (FDA) in the mid-1990s for diagnostic breast imaging. The recommended dose (20 mCi - 30 mCi) was established using an older, larger, less sensitive whole body imaging system. Newer breast-optimized imaging systems have an inherently higher photon sensitivity that may allow a lesser dose to be used.

At the Weinstein Imaging Center, BSGI has become a valuable diagnostic tool, especially for patients with dense breast tissue that limits the effectiveness of mammography. "In order to optimize care and use BSGI to screen specific populations, we wanted to examine the possibility of using a lesser dose," said Dr. Bohm-Velez. "The present challenge for the clinician is that the use of lower doses is currently an off-label use of the pharmaceutical."

The study compared breast tissue uptake at low-dose levels of 5 mCi, 10 mCi, and 15 mCi to those obtained with the traditional 20 mCi (740 MBq) injections. According to Dr. Bohm-Velez, "Although these are early results, we were quite surprised to see that we can reduce the dose to 15 mCi without any substantial impact on breast tissue uptake or image quality. Moreover, a 10-mCi image still provided a very good, clinically viable image. The good news is that at lower doses, the breast tissue uptake is still sufficient; leading us to believe that a dose of 8 mCi is likely possible with the current instrumentation."

Dr. Bohm-Velez also mentioned current studies are underway at the University of Virginia (Charlotte, VA, USA) to allow potentially doses as low as 2-4 mCi to be used, making the radiation dose a patient receives from a BSGI/MBI study equivalent to that from a mammogram. According to Dr. Bohm-Velez, "The next steps are to gain the funding needed to expand this to a multicenter trial, investigate the impact of these optimizations, and hopefully, in the end, change the drug insert package to include low-dose breast imaging."

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63 (68.187713623047): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (80.108642578125): select jos_twitters.link from jos_twitters where cat=10

65 (43.153762817383): select jos_facebook.link from jos_facebook where cat=10

66 (43.869018554688): select jos_google_plus.link from jos_google_plus where cat=10

67 (38.862228393555): select jos_linkedin.link from jos_linkedin where cat=10

68 (52.928924560547): SELECT fid FROM jos_deeppockets WHERE id=294735365 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294735365 AND published='1' LIMIT 1

69 (46.968460083008): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (569.82040405273): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294735365 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (437.97492980957): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294735365 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (60.081481933594): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (77.962875366211): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (72.002410888672): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (73.909759521484): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294735365 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (46.968460083008): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294735365 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (45.061111450195): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (77.962875366211): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (63.180923461914): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

105 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

106 (79.870223999023): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294735365 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (193.11904907227): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294735365 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

109 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

110 (66.041946411133): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294735365 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (757.93266296387): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294735365 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (828.02772521973): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (643.96858215332): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (175.95291137695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

115 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

116 (100.85105895996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

117 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

118 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

119 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

120 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

121 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

122 (452.04162597656): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 82067.012786865): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (658.98895263672): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294735365 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294735365 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 23450.85144043): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (231.02760314941): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (553.84635925293): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (58.889389038086): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (368.11828613281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (141.85905456543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (504.0168762207): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (55.074691772461): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (!!!!! 1142.9786682129): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (58.889389038086): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (595.0927734375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (!!!!! 2498.1498718262): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (70.095062255859): SELECT name FROM jos_deeppockets WHERE id=213

138 (!!!!! 11946.9165802): SELECT name FROM jos_deeppockets WHERE id=213

139 (!!!!! 1029.9682617188): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (!!!!! 1015.9015655518): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 1611.9480133057): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

142 (105.85784912109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

143 (!!!!! 21398.067474365): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 2549.8867034912): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294735365 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (114.91775512695): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294735365 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (613.92784118652): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (216.00723266602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (912.90473937988): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

149 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

150 (!!!!! 1730.9188842773): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (368.83354187012): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

152 (78.201293945312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

153 (79.870223999023): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294735365 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294735365 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (51.975250244141): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (42.915344238281): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (55.074691772461): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (740.05126953125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

158 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294735365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294735365 AND published='1' LIMIT 1

159 (62.942504882812): select jos_twitters.link from jos_twitters where cat=10

160 (42.915344238281): select jos_facebook.link from jos_facebook where cat=10

161 (41.007995605469): select jos_google_plus.link from jos_google_plus where cat=10

162 (38.862228393555): select jos_linkedin.link from jos_linkedin where cat=10

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