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Miniature, Wearable PET Scanner Ready for Use on Lab Rats

By MedImaging International staff writers
Posted on 24 Mar 2011
Scientists have demonstrated the effectiveness of a "wearable,” portable positron emission tomography (PET) scanner they have developed for research in laboratory rats. The technology will provide neuroscientists a new tool for simultaneously assessing brain function and behavior in fully awake, moving animals.

The researchers from the US Department of Energy's (DOE) Brookhaven National Laboratory, Stony Brook University (Stony Brook, NY, USA) described the tool and validation studies in the April 2011 issue of the journal Nature Methods. "PET is a powerful tool for studying the molecular processes that occur in the brain,” said Dr. Paul Vaska, head of PET physics at Brookhaven with a joint appointment at Stony Brook, who led the development of the portable scanner together with Brookhaven colleagues Dr. David Schlyer and DR. Craig Woody. PET studies in animals at Brookhaven and elsewhere have helped to reveal the molecular foundations of conditions such as drug addiction.

However, examining animals with PET imaging has required general anesthesia or other techniques to immobilize the animals. "Immobilization and anesthesia make it impossible to simultaneously study neurochemistry and the animals' behavior--the actions resulting from what goes on in the brain,” Dr. Schlyer said. "Our approach was to eliminate the need for restraint by developing a PET scanner that would move with the animal, thus opening up the possibility of directly correlating the imaging data with behavioral data acquired at the same time.”

After several years of development, the scientists have arrived at a design for a miniature, portable, donut-shaped PET scanner that can be "worn” like a collar on a rat's head for simultaneous studies of brain function and behavior. Weighing only 250 g, the device--named RatCAP (rat conscious animal PET), is counterbalanced by a system of springs and motion stabilizers to allow the animal significant freedom of movement.

Measurements of the rats' stress hormones indicated only moderate and temporary increases. "Rats wearing the device appear to adapt well and move freely about their environment,” Dr. Woody said.

To validate the use of the wearable scanner for simultaneous studies of brain function and behavior, the scientists conducted tests with 11C-raclopride, a typically used PET radiotracer, which incorporates a radioactive, positron-emitting isotope of the element carbon. When the positrons interact with electrons in ordinary matter, they immediately annihilate one another, emitting back-to-back gamma rays. Detectors in the circular PET scanner detect the signals from these back-to-back gamma rays to identify the location and concentration of the tracer in the body.

The tracer 11C-raclopride binds to receptors for dopamine, a brain chemical involved in movement, reward, and memory formation. A higher signal from the tracer means that less natural dopamine is in that specific part of the brain; a low signal indicates that that particular part of the brain has released dopamine (which binds to its receptors, thereby blocking the tracer from binding).

The key test was to see if the wearable scanner could be used to correlate dopamine levels with behavior--in this case, the rats' activity, i.e., movement, within their chambers. Unexpectedly, the level of activity was inversely related to dopamine levels--meaning, the more active the animals were, the lower the level of dopamine (as indicated by a stronger tracer signal).

"This is perhaps a counterintuitive result because behavioral activation is typically associated with an increase in dopamine release,” said Dr. Daniela Schulz, a Brookhaven behavioral neuroscientist and lead author of the paper. "So our method provides data which may challenge traditional paradigms and ultimately improve our understanding of the dopamine system. But regardless of the direction, the results clearly demonstrate that RatCAP can correlate brain function measurements with behavioral measures in a useful way.”

The scientists also presented study findings comparing RatCAP-wearing rats moving freely about their cages with animals that had been anesthetized, as well as comparisons of two methods of administering the tracer--injecting it all at once and in a steady infusion to maintain a constant concentration in the blood. "These measurements will help us further refine the technique and aid in our assessment of results obtained with RatCAP in comparison with other study techniques,” Dr. Schulz stated.

The researchers' next step will be to use RatCAP to explore distinct behavioral expressions that can be correlated with simultaneously acquired PET data. This research should enhance understanding of a wide array of human medical conditions including cancer, drug addiction, Alzheimer's and Parkinson's diseases, and normal aging. Earlier similar research led to the development of several promising treatment strategies.

Related Links:
Brookhaven National Laboratory, Stony Brook University



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88 (131.13021850586): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734030 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
89 (57.93571472168): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
90 (86.069107055664): SELECT show_live FROM jos_com_show_setting LIMIT 1
91 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1
92 (!!!!! 1399.9938964844): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (86.069107055664): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (40.769577026367): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (!!!!! 2703.9051055908): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
105 (159.97886657715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
106 (119.92454528809): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734030 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (691.89071655273): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734030 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (916.95785522461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
109 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
110 (161.17095947266): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294734030 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (818.01414489746): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294734030 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (922.91831970215): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (742.91229248047): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (143.05114746094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
115 (105.14259338379): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
116 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
117 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
118 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
119 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
120 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
121 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
122 (401.02005004883): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
123 (!!!!! 64100.980758667): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
124 (!!!!! 1176.118850708): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734030 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734030 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (!!!!! 26262.998580933): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (89.168548583984): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (814.91470336914): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
128 (90.122222900391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (303.98368835449): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
130 (!!!!! 1347.0649719238): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (571.96617126465): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
132 (61.03515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (68.902969360352): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
134 (48.160552978516): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (!!!!! 4184.9613189697): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
136 (!!!!! 3491.8785095215): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (!!!!! 3654.0031433105): SELECT name FROM jos_deeppockets WHERE id=213
138 (452.99530029297): SELECT name FROM jos_deeppockets WHERE id=213
139 (972.03254699707): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
140 (!!!!! 1075.9830474854): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (728.84559631348): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
142 (271.08192443848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
143 (!!!!! 30323.98223877): TRUNCATE TABLE jos_trademed_module
144 (!!!!! 3446.102142334): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734030 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
145 (290.87066650391): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734030 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (636.10076904297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147 (!!!!! 4507.7800750732): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (!!!!! 2755.880355835): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
149 (839.9486541748): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
150 (!!!!! 1864.1948699951): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
151 (!!!!! 7416.9635772705): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
152 (385.04600524902): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
153 (383.85391235352): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734030 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734030 AND type='deeppockets_item' AND published='1' LIMIT 1
154 (195.98007202148): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)
155 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)
156 (67.949295043945): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
157 (!!!!! 1003.9806365967): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
158 (183.10546875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734030 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734030 AND published='1' LIMIT 1
159 (38.862228393555): select jos_twitters.link from jos_twitters where cat=10
160 (26.941299438477): select jos_facebook.link from jos_facebook where cat=10
161 (213.8614654541): select jos_google_plus.link from jos_google_plus where cat=10
162 (377.17819213867): select jos_linkedin.link from jos_linkedin where cat=10