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Boron CT Radiotherapy Shown Effective for Advanced Head and Neck Cancer

By MedImaging International staff writers
Posted on 18 Mar 2011

New radiotherapy technology, biologically targeted boron computed tomography (BNCT) treatment, is based on producing radiation inside a tumor using boron-10 and thermal neutrons.

Boron-10 is introduced into cancer cells with the help of a special carrier compound (phenylalanine), after which the tumor is irradiated with low-energy neutrons. The latter react with the boron to generate high LET (linear energy transfer) radiation, which may destroy the cancer cells. One to two BNCT treatment sessions may be sufficient to destroy a tumor, while keeping the impact of radiation on surrounding healthy tissue to a minimum.

A research reactor is currently used as the neutron source, but customized neutron accelerators are being designed for BNCT. Clinical trials to evaluate the effectiveness and safety of BNCT in the treatment of locally recurrent head and neck cancer have been performed at the department of oncology at Helsinki University Central Hospital (HUCH; Finland). Apart from palliative chemotherapy, conventional treatment was no longer considered possible for the patients treated in the BNCT trials.

Thirty patients referred to HUCH's department of oncology from hospitals around Finland took part in the trial. Seventy-six percent of patients responded well to the treatment and 30% were still alive two years after treatment--while only one patient has survived 55 months. The results of the study, conducted by Prof. Heikki Joensuu, have recently been published in the April 1, 2011, issue of the International Journal of Radiation Oncology, Biology, Physics.

BNCT treatment is provided by Boneca Corp. (Helsinki, Finland), which is based at the main campus of Helsinki University Central Hospital and is the world's only provider of radiation safety-audited BNCT treatment. Boneca works closely with HUCH's department of oncology, and treatment-related decisions are taken jointly with the hospital's otolaryngology, radiation therapy, and oncology specialists. Boneca is responsible for administering the treatment, which is given at a special facility adjacent to the research nuclear reactor used at the VTT Technical Research Centre of Finland (Espoo, Finalnd).

"The positive results that we have achieved in treating head and neck tumors have convinced us of the benefits of further developing BNCT treatment and the services needed to administer it,” says the chairman of Boneca's Board of Directors, Seppo Pakkala, MD, PhD. "As BNCT saves healthy tissue, this promises to make it a good choice as a first-line therapy for patients with large head and neck tumors, avoiding the need for extensive surgery. Additional studies will be needed, however, before BNCT can be adopted for this use. We would also like to extend the use of BNCT to treating tumors in other anatomical areas for which there are no forms of treatment currently available.”

BNCT treatment has been given to over 200 patients to date, the majority of whom had recurred head and neck cancer or malignant brain tumor. Approximately 6% of patients have come from abroad as a result of international interest in BNCT.

"We have sufficient capacity to treat more patients and are very interested in collaborating with hospitals outside Finland that would like to offer the option of BNCT treatment for their patients,” said Boneca's CEO, Markku Pohjola.

Related links:

Helsinki University Central Hospital
Boneca

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62 (185.96649169922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

63 (!!!!! 5438.0893707275): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (!!!!! 1301.0501861572): SELECT fid FROM jos_deeppockets WHERE id=294733895 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294733895 AND published='1' LIMIT 1

65 (57.220458984375): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

66 (!!!!! 1471.0426330566): select jos_twitters.link from jos_twitters where cat=10

67 (53.167343139648): select jos_facebook.link from jos_facebook where cat=10

68 (44.107437133789): select jos_google_plus.link from jos_google_plus where cat=10

69 (37.908554077148): select jos_linkedin.link from jos_linkedin where cat=10

70 (272.98927307129): SELECT fid FROM jos_deeppockets WHERE id=294733895 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294733895 AND published='1' LIMIT 1

71 (!!!!! 1242.1607971191): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

72 (861.88316345215): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733895 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (!!!!! 1053.0948638916): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733895 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (54.121017456055): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (339.03121948242): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (241.99485778809): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (184.05914306641): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (695.94383239746): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (59.127807617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (!!!!! 5535.8409881592): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (68.902969360352): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (!!!!! 1239.0613555908): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733895 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (56.982040405273): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733895 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (56.028366088867): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (56.028366088867): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (26.226043701172): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (172.85346984863): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

107 (!!!!! 4045.0096130371): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

108 (70.810317993164): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733895 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (58.889389038086): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733895 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (119.92454528809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

111 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

112 (56.982040405273): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294733895 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (460.86311340332): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294733895 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (844.00177001953): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (602.96058654785): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

116 (183.10546875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

117 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

118 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

119 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

120 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

121 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

122 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

123 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

124 (347.85270690918): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 63544.034957886): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (!!!!! 5741.1193847656): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733895 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733895 AND type='deeppockets_item' AND published='1' LIMIT 1

127 (105.14259338379): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (53.167343139648): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

129 (!!!!! 2598.0472564697): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (891.92390441895): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

131 (145.91217041016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (220.06034851074): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

133 (224.11346435547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (108.00361633301): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

135 (116.10984802246): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (114.91775512695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

137 (756.02531433105): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (536.91864013672): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (66.995620727539): SELECT name FROM jos_deeppockets WHERE id=213

140 (46.968460083008): SELECT name FROM jos_deeppockets WHERE id=213

141 (736.95182800293): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (648.97537231445): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

144 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

145 (!!!!! 20251.989364624): TRUNCATE TABLE jos_trademed_module

146 (118.97087097168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733895 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (56.982040405273): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733895 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (608.92105102539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

151 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

152 (!!!!! 1693.0103302002): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

154 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

155 (58.889389038086): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733895 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733895 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (44.107437133789): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

157 (46.014785766602): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

158 (56.982040405273): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (117.06352233887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

160 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733895 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733895 AND published='1' LIMIT 1

161 (61.988830566406): select jos_twitters.link from jos_twitters where cat=10

162 (41.961669921875): select jos_facebook.link from jos_facebook where cat=10

163 (92.029571533203): select jos_google_plus.link from jos_google_plus where cat=10

164 (38.14697265625): select jos_linkedin.link from jos_linkedin where cat=10

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