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Revolutionizing Surgery with Real-Time Metabolic Profiling

By MedImaging International staff writers
Posted on 27 Jan 2011

Image: The NMR machine will rapidly analyze intact tissue samples from surgery patients (photo courtesy of Imperial College London).

Surgical metabonomics, the metabolic profiling of tissue samples, could transform the way surgeons make decisions in the operating theatre.

Researchers at the Imperial College London (ICL; London, United Kingdom) Surgical Metabonomics Laboratory (SML) are using a high-resolution solid-state nuclear magnetic resonance (NMR) spectrometer to analyze intact tissue samples, without preparation. Surgeons will be able to take tissue samples and have them loaded straight into the NMR machine, receiving a readily interpretable readout from the analysis within 20 minutes, which would provide information such as whether the tissues is infected or how good its blood supply is. Surgeons might also use the technology to determine exactly which areas of tissue are cancerous.

"This is a radical change of approach that doesn't just apply to surgery. We want to be able to provide a metabolic map of the entire patient journey. Before surgery, metabonomics could tell the doctor how risky surgery might be for that patient, or how best to prepare him for surgery,” said Prof. Jeremy Nicholson, PhD, a leading researcher in biomolecular medicine and head of the department of surgery and cancer, who will lead the SML together with surgical innovator Prof. Lord Ara Darzi, MD. "After the operation, metabonomics might help the doctor to monitor the patient's recovery and prescribe the most suitable drugs or diet. Ultimately we hope to apply this approach to every area of medicine.”

"People respond differently to the physical trauma of surgery, but currently the tools we have to measure how they respond are very limited,” added Lord Darzi. "Blood tests are slow and they can only measure one chemical component at a time; the doctor simply looks at whether a particular measure has gone up or down. Using NMR, we can simultaneously measure all of the chemicals that the body is producing, and analyze those data to give the surgeon real-time information about the patient's condition, which will help him make decisions.”

The science of metabonomics involves comprehensively measuring the metabolic changes in a person's body, using techniques from analytical chemistry that allow researchers to measure simultaneously all of the chemicals produced by the body's metabolism. With knowledge of which molecules correspond to which conditions in the body, this "metabolic fingerprint” can provide a wealth of information about the state of a person's health. Metabonomics has previously been applied to samples of bodily fluids (such as blood and urine) to look for indicators of disease or of how a person might respond to a particular drug.

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58 (450.13427734375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733148 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (!!!!! 1250.9822845459): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

60 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

61 (124.93133544922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

62 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

63 (99.897384643555): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (663.04206848145): SELECT fid FROM jos_deeppockets WHERE id=294733148 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294733148 AND published='1' LIMIT 1

65 (57.93571472168): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

66 (49.114227294922): select jos_twitters.link from jos_twitters where cat=10

67 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

68 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

69 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

70 (33.140182495117): SELECT fid FROM jos_deeppockets WHERE id=294733148 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294733148 AND published='1' LIMIT 1

71 (33.140182495117): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

72 (384.09233093262): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733148 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (309.94415283203): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733148 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (42.915344238281): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (72.002410888672): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (59.127807617188): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733148 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (31.948089599609): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733148 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (35.04753112793): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (63.896179199219): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (45.7763671875): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (108.95729064941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

107 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

108 (62.942504882812): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733148 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (52.928924560547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733148 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (86.784362792969): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

111 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

112 (475.16822814941): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294733148 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (411.9873046875): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294733148 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (57.93571472168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294733147 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (344.99168395996): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294733147 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (649.92904663086): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (394.10591125488): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

119 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

120 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

121 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

122 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

123 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

124 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

125 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

126 (401.97372436523): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

127 (!!!!! 25220.87097168): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

128 (545.02487182617): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733148 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733148 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 8498.1918334961): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (173.09188842773): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (70.810317993164): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

132 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

133 (72.956085205078): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

134 (38.862228393555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

135 (446.08116149902): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

136 (57.93571472168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

137 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

138 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

139 (637.05444335938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (550.0316619873): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (77.962875366211): SELECT name FROM jos_deeppockets WHERE id=213

142 (50.067901611328): SELECT name FROM jos_deeppockets WHERE id=213

143 (836.84921264648): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (858.06846618652): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

145 (110.86463928223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

146 (76.770782470703): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

147 (!!!!! 11048.078536987): TRUNCATE TABLE jos_trademed_module

148 (146.15058898926): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733148 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (83.208084106445): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733148 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

150 (571.96617126465): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

152 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

153 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

154 (!!!!! 1668.9300537109): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

155 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

156 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

157 (56.982040405273): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733148 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733148 AND type='deeppockets_item' AND published='1' LIMIT 1

158 (47.922134399414): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

159 (42.200088500977): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

160 (62.942504882812): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

161 (174.99923706055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

162 (484.94338989258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733148 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733148 AND published='1' LIMIT 1

163 (61.03515625): select jos_twitters.link from jos_twitters where cat=10

164 (41.007995605469): select jos_facebook.link from jos_facebook where cat=10

165 (39.815902709961): select jos_google_plus.link from jos_google_plus where cat=10

166 (39.815902709961): select jos_linkedin.link from jos_linkedin where cat=10

167 (385.04600524902): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

168 (!!!!! 1498.9376068115): insert into jos_banners_delta values (14615,'2025-08-20 13:15:39','216.73.216.0','view'),(14202,'2025-08-20 13:15:39','216.73.216.0','view'),(14203,'2025-08-20 13:15:39','216.73.216.0','view')

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