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Real-Time Visualization of Tumor Metabolism Possible with New Prostate Cancer Imaging Technology

By MedImaging International staff writers
Posted on 21 Dec 2010
Image: First Human Data: Hyperpolarized Pyruvate Injection in Subjects with Prostate Cancer (Photo courtesy University of California, San Francisco / GE Healthcare).
Image: First Human Data: Hyperpolarized Pyruvate Injection in Subjects with Prostate Cancer (Photo courtesy University of California, San Francisco / GE Healthcare).
Research collaboration has produced the first results in human trials of a new technology that has the potential to evaluate quickly the presence and aggressiveness of prostate tumors in real time, by imaging the tumor's metabolism. This is the first time researchers have employed this technology to perform real-time metabolic imaging in a human patient and represents a groundbreaking approach to assessing the precise outlines of a tumor, its response to treatment, and how rapidly it is growing.

Data on the first four patients were presented on December 2, 2010, at the Radiology Society of North America's (RSNA) weeklong annual conference held in Chicago, IL, USA. The initial results, from a collaboration of researchers from the University of California, San Francisco (UCSF; USA) and GE Healthcare (Chalfont St. Giles, UK), confirm extensive preclinical research that has tied the speed at which tumors metabolize nutrients to the aggressiveness of their growth. The new imaging technique also has been used to show early biochemical changes in animal tumors in real time as they respond to medication therapy, long before a physical change occurs.

Up to now, the technology has produced the same response in human patients' tumors as it did in laboratory studies, even at the lowest dose, according to Sarah Nelson, PhD, a professor of radiology and biomedical imaging and a member of the California Institute for Quantitative Biosciences (QB3) at UCSF. "This is a key milestone that could dramatically change clinical treatment for prostate cancer and many other tumors,” Dr. Nelson said. "We had shown this worked in animal models and tissues samples. Now, in men, we are seeing exactly the type of results we had hoped for.”

The method uses compounds involved in normal tissue function--in this case, pyruvate, which is a naturally occurring by-product of glucose, and lactate, also known as lactic acid--and uses newly developed equipment to increase the visibility of those compounds by a factor of 50,000 in a magnetic resonance imaging (MRI) scanner.

That process requires pyruvate to be prepared in a strong magnetic field at a temperature of -272 oC, then rapidly warmed to body temperature and transferred to the patient in an MRI scanner before the polarization decays back to its native state. The result is a highly defined and clear image of the tumor's outline, as well as a graph of the amount of pyruvate in the tumor and the rate at which the tumor converts the pyruvate into lactate.

The procedure must take place within minutes, which meant integrating a clean room into the scanning facility. The first trial involves men with prostate cancer involved in the "watchful waiting” phase of treatment, according to Dr. Nelson. Future studies will directly compare these data with the findings from surgically removed tumors and will look at how specific therapies change tumor metabolism. UCSF also will be studying the process for use in brain tumor patients.

For an oncologist, that means immediate feedback on whether a patient's therapy is working, either during standard treatment or in a clinical trial. "If we can see whether a therapy is effective in real time, we may be able to make early changes in that treatment that could have a very real impact on a patient's outcome and quality of life,” said Andrea Harzstark, MD, an oncologist with the UCSF Helen Diller Family Comprehensive Cancer Center who is leading the clinical aspects of the current study.

The disease ranges widely in its rate of growth and aggressiveness, according to John Kurhanewicz, PhD, a UCSF expert in prostate cancer imaging. As a result, there is great debate over the ideal strategy for treating the disease, he reported, leaving patients with a difficult and potentially life-changing decision over how aggressively to respond to the disease.

"This test could give both physicians and patients the information they need to make that decision,” said Dr. Kurhanewicz, whose work with Dan Vigneron, PhD, and their colleagues from the UCSF department of radiology and biomedical imaging first linked a prostate tumor's production of lactate to tumor aggressiveness. Other researchers also have linked that lactate production to tumor aggressiveness and response to therapy in other cancers.

Related Links:
University of California, San Francisco
GE Healthcare


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86 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1
87 (56.982040405273): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294732612 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
88 (37.908554077148): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294732612 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
89 (43.869018554688): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
90 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1
91 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1
92 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (74.148178100586): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (73.909759521484): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (!!!!! 3648.9963531494): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
105 (136.8522644043): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
106 (87.02278137207): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732612 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (631.09397888184): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732612 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
109 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
110 (84.877014160156): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294732612 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (738.14392089844): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294732612 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (669.95620727539): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (377.89344787598): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (478.02925109863): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
115 (260.1146697998): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
116 (376.93977355957): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
117 (159.02519226074): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
118 (172.13821411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
119 (393.86749267578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
120 (356.19735717773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
121 (190.01960754395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
122 (280.85708618164): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
123 (!!!!! 50719.022750854): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
124 (651.12113952637): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294732612 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294732612 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (!!!!! 19021.987915039): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (85.115432739258): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (43.153762817383): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
128 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
130 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (298.02322387695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
132 (33.855438232422): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
134 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (436.06758117676): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
136 (270.12825012207): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (113.01040649414): SELECT name FROM jos_deeppockets WHERE id=213
138 (31.948089599609): SELECT name FROM jos_deeppockets WHERE id=213
139 (621.79565429688): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
140 (511.88468933105): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (110.86463928223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
142 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
143 (!!!!! 4386.1865997314): TRUNCATE TABLE jos_trademed_module
144 (!!!!! 1103.8780212402): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732612 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
145 (68.902969360352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732612 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (320.9114074707): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
149 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
150 (!!!!! 1123.9051818848): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
151 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
152 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
153 (37.908554077148): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294732612 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294732612 AND type='deeppockets_item' AND published='1' LIMIT 1
154 (366.9261932373): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)
155 (36.954879760742): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)
156 (30.994415283203): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
157 (!!!!! 8411.8843078613): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
158 (212.9077911377): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732612 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732612 AND published='1' LIMIT 1
159 (44.107437133789): select jos_twitters.link from jos_twitters where cat=10
160 (!!!!! 1041.8891906738): select jos_facebook.link from jos_facebook where cat=10
161 (219.10667419434): select jos_google_plus.link from jos_google_plus where cat=10
162 (248.90899658203): select jos_linkedin.link from jos_linkedin where cat=10
163 (259.8762512207): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)
164 (!!!!! 2199.8882293701): insert into jos_banners_delta values (14615,'2025-06-27 16:24:39','216.73.216.249','view'),(14202,'2025-06-27 16:24:39','216.73.216.249','view'),(14203,'2025-06-27 16:24:39','216.73.216.249','view')