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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Positron Emission Mammography Scanners Offer an Alternative Screening Method for Women Who Cannot Tolerate MRI

By MedImaging International staff writers
Posted on 07 Dec 2010

Image: A positron emission mammography (PEM) system (photo courtesy of Naviscan).

A multisite study of hundreds of women with newly diagnosed breast cancer revealed that positron emission mammography (PEM) might reduce unnecessary breast biopsies. The study found that PEM was significantly more precise at identifying benign and cancerous lesions, in what scientists call positive predictive value (PPV), therefore reducing the number of unnecessary biopsies.

The new data came from a US National Institutes of Health (NIH; Bethesda, MD, USA)-sponsored multisite study. A common physician complaint regarding the use of breast magnetic resonance imaging (MRI) is its tendency to identify suspicious lesions, requiring biopsies, which ultimately are found to be benign.

This finding is a welcomed outcome for women and physicians looking for ways to reduce the patient trauma associated with biopsies and for payers looking to reduce the costs associated with unnecessary procedures. The findings from 388 woman in the study revealed that PEM not only demonstrated a 6% improvement in specificity at comparably high sensitivity, but that PEM also had 31 fewer unnecessary biopsies and 26% higher PPV than breast MR. These findings are also particularly significant for those women who cannot tolerate an MR exam and require an alternate imaging tool.

"The results of this study mean that not only do physicians have an additional, powerful tool to help treat breast cancer but that PEM is a legitimate and better alternative for the 16% of women who cannot tolerate MR due to claustrophobia, metallic implants, body habitus, or gadolinium reaction,” said Wendie Berg, MD, PhD and lead investigator for the trial. Dr. Berg recently published an article in the January 2010 issue in the journal Radiology assessing the reasons why high-risk women who were recommended for a MR breast-screening test refused to take the exam.

PEM scanners are high-resolution breast positron emission tomography (PET) systems that can show the location as well as the metabolic phase of a lesion. This information is vital in determining whether a lesion is malignant and influences the course of treatment. Other imaging systems, such as mammography and ultrasound, show only the location, not the metabolic phase. PEM scanners, which are about the size of an ultrasound system, are manufactured by Naviscan, Inc. (San Diego, CA, USA) and have been commercially available since 2007.

Related Links:
National Institutes of Health
Naviscan

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66 (!!!!! 3809.928894043): select jos_google_plus.link from jos_google_plus where cat=10

67 (!!!!! 1484.1556549072): select jos_linkedin.link from jos_linkedin where cat=10

68 (66.995620727539): SELECT fid FROM jos_deeppockets WHERE id=294732373 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294732373 AND published='1' LIMIT 1

69 (37.908554077148): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (215.05355834961): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294732373 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (191.92695617676): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294732373 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (39.100646972656): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (747.9190826416): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (24.080276489258): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (23.841857910156): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (43.869018554688): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294732373 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (27.179718017578): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294732373 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (29.802322387695): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (632.04765319824): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (177.86026000977): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (104.90417480469): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (114.91775512695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

105 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

106 (121.11663818359): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732373 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (67.949295043945): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732373 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (94.175338745117): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

109 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

110 (65.088272094727): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294732373 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (535.01129150391): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294732373 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (604.15267944336): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (344.03800964355): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

115 (65.803527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

116 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

117 (68.187713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

118 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

119 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

120 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

121 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

122 (176.90658569336): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 18810.987472534): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (380.9928894043): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294732373 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294732373 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 7907.1521759033): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (92.029571533203): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (33.855438232422): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (226.02081298828): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (64.849853515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (336.88545227051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (217.19932556152): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (35.04753112793): SELECT name FROM jos_deeppockets WHERE id=213

138 (27.894973754883): SELECT name FROM jos_deeppockets WHERE id=213

139 (606.06002807617): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (473.0224609375): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

142 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

143 (!!!!! 8023.9772796631): TRUNCATE TABLE jos_trademed_module

144 (112.05673217773): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732373 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (77.962875366211): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732373 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (810.14633178711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

149 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

150 (!!!!! 1150.1312255859): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

152 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

153 (31.948089599609): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294732373 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294732373 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (27.894973754883): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (27.894973754883): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (112.05673217773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

158 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732373 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732373 AND published='1' LIMIT 1

159 (38.862228393555): select jos_twitters.link from jos_twitters where cat=10

160 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

161 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

162 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

163 (335.9317779541): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1132.0114135742): insert into jos_banners_delta values (14615,'2025-06-27 21:06:22','216.73.216.249','view'),(14202,'2025-06-27 21:06:22','216.73.216.249','view'),(14203,'2025-06-27 21:06:22','216.73.216.249','view')

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