Download Mobile App

Video Library

Novel Target for Drug May Improve Effectiveness of Radiation Therapy

By MedImaging International staff writers
Posted on 13 Oct 2010

Image: Inhibition of the enzyme cPLA2 leads to collapsed vessels, stopping blood flow to the tumor (photo courtesy Washington University in St. Louis).

Scientists have found a new drug target that could improve the effectiveness of radiation for hard-to-treat cancers.

The study's findings, published online August 20, 2010, in the Journal of the National Cancer Institute, focuses on the role of the enzyme cytosolic phospholipase A2 (cPLA2). This enzyme promotes development and functioning of blood vessel networks that feed malignant tumors, enabling them to overcome the effects of radiation. They have also identified a drug that blocks production of the enzyme. Inhibiting the enzyme can stop the flow of blood tumors need to survive.

Tumors thrive and spread due to a unique ability to recruit networks of new blood vessels that penetrate into tumors, bringing oxygen, nutrients,and potentially transporting cancer cells to other areas of the body. Cancer cells trigger the process of new blood vessel construction, called angiogenesis, by releasing specific molecules into surrounding normal tissue, initiating a cascade of molecular signals that cause cells lining existing blood vessels to divide and create new vessels. These new vessel networks link the tumor to the circulatory system and its life-sustaining cargo.

Lung cancer and glioblastoma, the most common type of primary brain tumor, are particularly skillful at inducing new blood vessel creation via angiogenesis. They are also highly resistant to treatment by radiation. "Our original objective was to measure the signaling molecules that enable lung and brain cancer to be resistant to radiation,” noted Dennis Hallahan, M.D., a professor of medicine and chair of the department of radiation oncology at Washington University School of Medicine in St. Louis (MO, USA) and senior author of the study. "There are hundreds of signaling molecules, but the enzyme cPLA2 stood out,” Dr. Hallahan stated. "Radiation of tumor cells triggers production of cPLA2 within two minutes and it contributes to tumor survival.”

The cPLA2 enzyme is known to regulate the levels of at last three molecules that promote tumor angiogenesis (the creation of new blood vessel networks to feed cancer cells). The researchers set out to learn if they could enhance the effect of radiation therapy for lung and brain cancers by inhibiting this enzyme. The plan was to implant tumors into normal mice and into mice that had been genetically engineered to be unable to produce cPLA2 and then compare the effect of radiation therapy on tumor progression in each.

The enormous power of cPLA2 became apparent to Dr. Hallahan when a graduate student complained that her experiment failed because she could not grow tumors in mice that lacked the gene that produces cPLA2. "While implanted tumors progressed as expected in normal mice used in the experiment, they were virtually undetectable in cPLA2-deficient mice,” Dr. Hallahan stated. "The ‘failed experiment' was actually a significant discovery of the enormous control cPLA2 has in regulating tumor angiogenesis.”

The scientists then studied the blood vessels of the cPLA2-deficient mice. Whereas the blood vessels of cPLA2-deficient mice appeared normal, close inspection revealed the absence of a specific type of contractile cell that regulates blood flow. "Without these cells, blood vessels can still grow into the tumor but blood cannot flow to the tumor,” Dr. Hallahan stated. "Cancer cannot survive without blood flow to feed it.”

The essential role of cPLA2 in determining the presence or absence of these contractile cells makes it a prime target for interventional therapy. "Drugs that target cPLA2 have enormous potential for improving the success of radiation against highly angiogenic tumors,” Dr. Hallahan said.

Dr. Hallahan has already identified an existing drug that inhibits cPLA2. It is a compound originally developed by Wyeth (Madison, NJ, USA), now part of Pfizer (New York, NY, USA), as a treatment for arthritis. The drug had advanced to phase II testing before being discontinued as a potential arthritis treatment. Reaching phase II testing, however, suggests that a compound has been proven safe, regardless of whether or not it meets performance standards for the specific medical condition for which it was made. These drugs are typically then tested for other uses.

Dr. Hallahan learned of the Pfizer compound from a partnership between Pfizer and Washington University that allows Washington University scientists to evaluate extensive research data on a large range of Pfizer pharmaceutical candidates that are or were in clinical testing.

Don Frail, Ph.D., chief scientific officer of Pfizer's Indication's Discovery Unit, reported that most of drug candidates tested in development do not give the desired result. "Yet those drugs that do succeed typically have multiple uses,” Dr. Frail said. "Hallahan's research has led to an entirely new potential use for one of these compounds in an area of high patient need that otherwise might have been overlooked. This is exactly what our partnership with Washington University is about and is among the first to be funded through the new relationship.”

Dr. Hallahan is currently collaborating with Craig Wegner, Ph.D., in the Indications Discovery Unit of Pfizer to understand further the pathways impacted by cPLA2 and to assess the drug that suppresses its action.

Related Links:
Washington University School of Medicine in St. Louis
Pfizer

Visit expo >

Gold Member

Ultrasound System

FUTUS LE

Gold Member

Electrode Solution and Skin Prep

Signaspray

Afterloader For Brachytherapy

Flexitron

Web-Based DICOM Viewer

iQ-4VIEW

Latest Nuclear Medicine News

Channels

Radiography

view channel

Image: A 4mm square diamond radiation detector (Photo courtesy of Orbray)

World's Largest Class Single Crystal Diamond Radiation Detector Opens New Possibilities for Diagnostic Imaging

Diamonds possess ideal physical properties for radiation detection, such as exceptional thermal and chemical stability along with a quick response time. Made of carbon with an atomic number of six, diamonds... Read more

Image: The AI-powered FFR assessment is comparable to conventional assessment (Photo courtesy of 123RF)

MRI

view channel

Image: An AI tool has shown tremendous promise for predicting relapse of pediatric brain cancer (Photo courtesy of 123RF)

AI Tool Predicts Relapse of Pediatric Brain Cancer from Brain MRI Scans

Many pediatric gliomas are treatable with surgery alone, but relapses can be catastrophic. Predicting which patients are at risk for recurrence remains challenging, leading to frequent follow-ups with... Read more

AI Tool Tracks Effectiveness of Multiple Sclerosis Treatments Using Brain MRI Scans

Multiple sclerosis (MS) is a condition in which the immune system attacks the brain and spinal cord, leading to impairments in movement, sensation, and cognition. Magnetic Resonance Imaging (MRI) markers... Read more

Ultra-Powerful MRI Scans Enable Life-Changing Surgery in Treatment-Resistant Epileptic Patients

Approximately 360,000 individuals in the UK suffer from focal epilepsy, a condition in which seizures spread from one part of the brain. Around a third of these patients experience persistent seizures... Read more

Image: The automated MRI processing and machine learning software features a noninvasive biomarker technique (Photo courtesy of University of Florida)

AI-Powered MRI Technology Improves Parkinson’s Diagnoses

Current research shows that the accuracy of diagnosing Parkinson’s disease typically ranges from 55% to 78% within the first five years of assessment. This is partly due to the similarities shared by Parkinson’s... Read more

Ultrasound

view channel

AI-Powered Lung Ultrasound Outperforms Human Experts in Tuberculosis Diagnosis

Despite global declines in tuberculosis (TB) rates in previous years, the incidence of TB rose by 4.6% from 2020 to 2023. Early screening and rapid diagnosis are essential elements of the World Health... Read more

Image: Researchers are using AI to analyze images from a common heart test to identify signs of valve disease (Photo courtesy of 123RF)

AI Identifies Heart Valve Disease from Common Imaging Test

Tricuspid regurgitation is a condition where the heart's tricuspid valve does not close completely during contraction, leading to backward blood flow, which can result in heart failure. A new artificial... Read more

Image: Diagram of ULM processing (Photo courtesy of Cyborg and Bionic Systems)

Novel Imaging Method Enables Early Diagnosis and Treatment Monitoring of Type 2 Diabetes

Type 2 diabetes is recognized as an autoimmune inflammatory disease, where chronic inflammation leads to alterations in pancreatic islet microvasculature, a key factor in β-cell dysfunction.... Read more

Image: Artist’s impression of the new ultrasound technique, called nonlinear sound sheet microscopy (Photo courtesy of Maayan Harel/Maresca Lab)

Ultrasound-Based Microscopy Technique to Help Diagnose Small Vessel Diseases

Clinical ultrasound, commonly used in pregnancy scans, provides real-time images of body structures. It is one of the most widely used imaging techniques in medicine, but until recently, it had little... Read more

General/Advanced Imaging

view channel

Image: The LungVision system has received regulatory approval from the TGA in Australia (Photo courtesy of Body Vision Medical)

AI-Powered Imaging System Improves Lung Cancer Diagnosis

Given the need to detect lung cancer at earlier stages, there is an increasing need for a definitive diagnostic pathway for patients with suspicious pulmonary nodules. However, obtaining tissue samples... Read more

Image: The multimodal multitask foundation model enhances lung cancer screening (Photo courtesy of 123RF)

AI Model Significantly Enhances Low-Dose CT Capabilities

Lung cancer remains one of the most challenging diseases, making early diagnosis vital for effective treatment. Fortunately, advancements in artificial intelligence (AI) are revolutionizing lung cancer... Read more

Image: Axial noncontrast chest CT lung window images of three different sample patches shown in each row (Photo courtesy of Radiology: Cardiothoracic Imaging)

Ultra-Low Dose CT Aids Pneumonia Diagnosis in Immunocompromised Patients

Lung infections can be life-threatening for patients with weakened immune systems, making timely diagnosis crucial. While CT scans are considered the gold standard for detecting pneumonia, repeated scans... Read more

Image: Histologically confirmed lung cancer cases detected at immediate referral after baseline scan or 3-month short-term follow-up (Photo courtesy of DOI:10.1016/j.ejca.2025.115324)

AI Reduces CT Lung Cancer Screening Workload by Almost 80%

Lung cancer impacts over 48,000 individuals in the UK annually, and early detection is key to improving survival rates. The UK Lung Cancer Screening (UKLS) trial has already shown that low-dose CT (LDCT)... Read more

Imaging IT

view channel

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more

Global AI in Medical Diagnostics Market to Be Driven by Demand for Image Recognition in Radiology

The global artificial intelligence (AI) in medical diagnostics market is expanding with early disease detection being one of its key applications and image recognition becoming a compelling consumer proposition... Read more

AI-Based Mammography Triage Software Helps Dramatically Improve Interpretation Process

An artificial intelligence (AI)-based mammography triage software is helping dramatically improve the interpretation process for healthcare providers. In a new study, researchers at the Scripps Green... Read more

Artificial Intelligence (AI) Program Accurately Predicts Lung Cancer Risk from CT Images

An artificial intelligence (AI) program accurately predicts the risk that lung nodules detected on screening CT will become cancerous, according to a study published in the journal Radiology.... Read more

Industry News

view channel

GE HealthCare and NVIDIA Collaboration to Reimagine Diagnostic Imaging

GE HealthCare (Chicago, IL, USA) has entered into a collaboration with NVIDIA (Santa Clara, CA, USA), expanding the existing relationship between the two companies to focus on pioneering innovation in... Read more

Image: The patient-specific 3D-printed phantoms usher in a new era for medical imaging research (Photo courtesy of Siemens Healthineers)

Patient-Specific 3D-Printed Phantoms Transform CT Imaging

New research has highlighted how anatomically precise, patient-specific 3D-printed phantoms are proving to be scalable, cost-effective, and efficient tools in the development of new CT scan algorithms... Read more

Siemens and Sectra Collaborate on Enhancing Radiology Workflows

Siemens Healthineers (Forchheim, Germany) and Sectra (Linköping, Sweden) have entered into a collaboration aimed at enhancing radiologists' diagnostic capabilities and, in turn, improving patient care... Read more

Image: Virtual colonoscopy (CT colonography) is an approved option for screening for colorectal cancer in the US (Photo courtesy of Shtutterstock)

Bracco Diagnostics and ColoWatch Partner to Expand Availability CRC Screening Tests Using Virtual Colonoscopy

Over the last 25 years, virtual colonoscopy has been proven to be a highly accurate, safe, convenient, and cost-effective method of colorectal cancer (CRC) prevention and screening. It can reliably find... Read more

1 (53.882598876953): SET sql_mode = 'MYSQL40'

2 (50.067901611328): SELECT folder, element, published, params FROM jos_mambots WHERE published >= 1 AND access <= 0 AND folder = 'system' ORDER BY ordering

3 (285.86387634277): SELECT template FROM jos_templates_menu WHERE client_id = 0 AND ( menuid = 0 OR menuid = 294731558 ) ORDER BY menuid DESC LIMIT 1

4 (322.10350036621): DELETE FROM jos_session WHERE time < 1755520754 AND guest = 1 AND userid = 0

5 (36.954879760742): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

6 (30.040740966797): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

7 (30.040740966797): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

8 (!!!!! 1801.9676208496): SELECT * FROM jos_menu WHERE id = 294731558

9 (!!!!! 3542.9000854492): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

10 (770.09201049805): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

11 (99.897384643555): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

12 (941.99180603027): SELECT * FROM jos_deeppockets WHERE 1=1 AND cat=10 AND type='deeppockets_item' AND published='1' AND (id<>294731558) AND (fid=213) ORDER BY id DESC, `created` DESC LIMIT 0,16

13 (339.98489379883): SELECT * FROM jos_deeppockets WHERE 1=1 AND cat=10 AND type='deeppockets_item' AND published='1' AND (id<>294731558) AND (fid=213) ORDER BY id DESC, `created` DESC LIMIT 0,16

14 (!!!!! 4778.1467437744): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_item.fid=213 and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294731558 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

15 (!!!!! 6855.0109863281): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_item.fid=213 and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294731558 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

16 (!!!!! 4397.1538543701): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294731558 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

17 (!!!!! 3812.7899169922): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294731558 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

18 (71.048736572266): SELECT name,id,title FROM jos_deeppockets WHERE id=213 LIMIT 1

19 (34.809112548828): SELECT name,id,title FROM jos_deeppockets WHERE id=213 LIMIT 1

20 (481.84394836426): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

21 (566.00570678711): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

22 (87.976455688477): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

23 (52.928924560547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

24 (586.98654174805): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

25 (455.85632324219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

26 (57.220458984375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

27 (58.889389038086): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

28 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

29 (57.93571472168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

30 (60.081481933594): SELECT conference_items.channel_id, conference_items.tracking_code FROM conference_items LEFT JOIN conference_groups ON conference_groups.id = conference_items.group_id LEFT JOIN jos_deeppockets ON jos_deeppockets.id = conference_items.channel_id LEFT JOIN jos_journal ON jos_journal.cat = jos_deeppockets.cat AND jos_journal.real = 1 AND jos_journal.directory IS NOT NULL WHERE 1 = 1 ORDER BY conference_items.id

31 (349.99847412109): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294731558 LIMIT 1

32 (107.76519775391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294731558 LIMIT 1

33 (283.95652770996): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294731558 LIMIT 1

34 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294731558 LIMIT 1

35 (763.89312744141): SELECT id, title, module, position, content, showtitle, params FROM jos_modules AS m INNER JOIN jos_modules_menu AS mm ON mm.moduleid = m.id WHERE m.published = 1 AND m.access <= 0 AND m.client_id != 1 AND ( mm.menuid = 0 OR mm.menuid = 294731558 ) ORDER BY ordering

36 (!!!!! 2868.8907623291): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

37 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

38 (48.87580871582): SELECT * FROM jos_bannersmanager_banner WHERE `groupid` = 98 AND `site_id` = 10 AND `published` = 1

39 (35.04753112793): SELECT * FROM jos_bannersmanager_banner WHERE `groupid` = 99 AND `site_id` = 10 AND `published` = 1

40 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

41 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

42 (83.92333984375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294731558 LIMIT 1

43 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294731558 LIMIT 1

44 (33.855438232422): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294731558 LIMIT 1

45 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294731558 LIMIT 1

46 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

47 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

48 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

49 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

50 (83.208084106445): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

51 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

52 (260.82992553711): SELECT name FROM jos_deeppockets WHERE id=294731558 LIMIT 1

53 (185.01281738281): SELECT name FROM jos_deeppockets_archive WHERE id=294731558 LIMIT 1

54 (41.961669921875): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

55 (59.843063354492): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

56 (396.0132598877): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (!!!!! 1366.138458252): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

58 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

59 (174.04556274414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

60 (183.8207244873): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

61 (104.90417480469): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (550.98533630371): SELECT fid FROM jos_deeppockets WHERE id=294731558 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294731558 AND published='1' LIMIT 1

63 (45.061111450195): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (78.916549682617): select jos_twitters.link from jos_twitters where cat=10

65 (46.014785766602): select jos_facebook.link from jos_facebook where cat=10

66 (33.855438232422): select jos_google_plus.link from jos_google_plus where cat=10

67 (29.802322387695): select jos_linkedin.link from jos_linkedin where cat=10

68 (51.021575927734): SELECT fid FROM jos_deeppockets WHERE id=294731558 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294731558 AND published='1' LIMIT 1

69 (33.855438232422): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (406.02684020996): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731558 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (249.86267089844): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731558 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (46.014785766602): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (64.13459777832): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (60.081481933594): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731558 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (40.054321289062): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731558 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (50.067901611328): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (94.890594482422): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (85.830688476562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

105 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

106 (77.009201049805): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (61.03515625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (111.10305786133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

109 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

110 (89.883804321289): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (743.86596679688): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (656.8431854248): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (535.96496582031): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (123.02398681641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

115 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

116 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

117 (37.193298339844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

118 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

119 (37.193298339844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

120 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

121 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

122 (336.88545227051): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 25814.056396484): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (498.77166748047): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731558 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731558 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 8530.1399230957): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (123.97766113281): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (77.009201049805): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (87.976455688477): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (410.07995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (82.015991210938): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (62.942504882812): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (524.99771118164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (418.90144348145): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (43.869018554688): SELECT name FROM jos_deeppockets WHERE id=213

138 (47.922134399414): SELECT name FROM jos_deeppockets WHERE id=213

139 (854.9690246582): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (708.10317993164): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

142 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

143 (!!!!! 11008.024215698): TRUNCATE TABLE jos_trademed_module

144 (98.943710327148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (57.93571472168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731558 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (900.0301361084): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (267.02880859375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (729.08401489258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

149 (178.09867858887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

150 (!!!!! 1513.0043029785): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

152 (813.96102905273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

153 (725.98457336426): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731558 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731558 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (51.021575927734): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (197.8874206543): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (!!!!! 1204.0138244629): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 3278.0170440674): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

158 (!!!!! 1687.0498657227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731558 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731558 AND published='1' LIMIT 1

159 (47.922134399414): select jos_twitters.link from jos_twitters where cat=10

160 (!!!!! 2519.8459625244): select jos_facebook.link from jos_facebook where cat=10

161 (57.220458984375): select jos_google_plus.link from jos_google_plus where cat=10

162 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

Download Mobile App

Video Library

Novel Target for Drug May Improve Effectiveness of Radiation Therapy

Latest Nuclear Medicine News

Channels

Radiography

World's Largest Class Single Crystal Diamond Radiation Detector Opens New Possibilities for Diagnostic Imaging

AI-Powered Imaging Technique Shows Promise in Evaluating Patients for PCI

Higher Chest X-Ray Usage Catches Lung Cancer Earlier and Improves Survival

AI-Powered Mammograms Predict Cardiovascular Risk

MRI

AI Tool Predicts Relapse of Pediatric Brain Cancer from Brain MRI Scans

AI Tool Tracks Effectiveness of Multiple Sclerosis Treatments Using Brain MRI Scans

Ultra-Powerful MRI Scans Enable Life-Changing Surgery in Treatment-Resistant Epileptic Patients

AI-Powered MRI Technology Improves Parkinson’s Diagnoses

Ultrasound

AI-Powered Lung Ultrasound Outperforms Human Experts in Tuberculosis Diagnosis

AI Identifies Heart Valve Disease from Common Imaging Test

Novel Imaging Method Enables Early Diagnosis and Treatment Monitoring of Type 2 Diabetes

Ultrasound-Based Microscopy Technique to Help Diagnose Small Vessel Diseases

General/Advanced Imaging

AI-Powered Imaging System Improves Lung Cancer Diagnosis

AI Model Significantly Enhances Low-Dose CT Capabilities

Ultra-Low Dose CT Aids Pneumonia Diagnosis in Immunocompromised Patients

AI Reduces CT Lung Cancer Screening Workload by Almost 80%

Imaging IT

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Global AI in Medical Diagnostics Market to Be Driven by Demand for Image Recognition in Radiology

AI-Based Mammography Triage Software Helps Dramatically Improve Interpretation Process

Artificial Intelligence (AI) Program Accurately Predicts Lung Cancer Risk from CT Images

Industry News

GE HealthCare and NVIDIA Collaboration to Reimagine Diagnostic Imaging

Patient-Specific 3D-Printed Phantoms Transform CT Imaging

Siemens and Sectra Collaborate on Enhancing Radiology Workflows

Bracco Diagnostics and ColoWatch Partner to Expand Availability CRC Screening Tests Using Virtual Colonoscopy

MedImaging

Channels

Features

Partner Sites

Archive:

Click for LinkXpress Reader Inquiry Service
Enter code to receive information:

Where I can find code?

LinkXpress

Download Mobile App

Video Library

Novel Target for Drug May Improve Effectiveness of Radiation Therapy

Latest Nuclear Medicine News

Channels

MedImaging

Channels

Features

Partner Sites

Archive: