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Pencil Beam Scanning Lung Cancer Radiotherapy Delivered Successfully at German Proton Therapy Center

By MedImaging International staff writers
Posted on 07 Oct 2010

Germany clinicians are employing advanced proton therapy technology for the treatment of difficult lung cancer patients.

The treatments were performed at the Rinecker Proton Therapy Center (RPTC; Munich, Germany) using proton therapy systems supplied by Varian Medical Systems (Palo Alto, CA, USA). A 75-year-old patient with a large tumor in the right upper lung received 18 proton therapy treatments over three months. "By the end of the proton therapy treatment the tumor had halved in size and we expect it to regress further," said Prof. Manfred Herbst, medical director at RPTC.

Another patient with cancer in the left lung received a course of proton therapy at RPTC, which was able to protect the healthy right lung while at the same time keeping much of the remaining healthy tissue in the affected lung free of radiation. "A significant improvement in breathing was achieved after eight treatment days at the RPTC,” said Prof. Herbst. "Image-based clinical monitoring using computer tomography showed a clear reduction of the tumor volume.” Early results of both these innovative treatments were encouraging, according to RPTC clinicians.

To reduce tumor motion and increase targeted dose delivery during lung cancer treatments, patients at RPTC have controlled inflation of the lungs with oxygen during the application of a light anesthesia.

Whereas traditional X-ray based radiotherapy utilizes photons and electrons to destroy tumors, proton therapy involves delivering heavy proton particles with a unique energy characteristic to destroy tumors. The proton energy has a predictable drop-off that enables oncologists to deposit the peak of the energy within the tumor and reduce the exposure to the surrounding healthy tissue. Proton therapy enables oncologists to increase dose control and limit exposure to healthy tissue while treating cancer and other indications. The advanced treatment technique used at RPTC--called pencil beam scanning--enhances precision by enabling clinicians to maximize dose to the tumor while minimizing dose to nearby sensitive organs and tissue.

"Proton therapy could prove to be a very valuable weapon in the fight against lung cancer,” added Dr. Herbst. Recent findings from similar studies suggest that proton radiation treatment could potentially be more effective even than surgery in many cases of lung cancer. This research also reveals that proton therapy may reduce radiation exposure of healthy lung tissue and adjacent organs.

Related Links:
Rinecker Proton Therapy Center
Varian Medical Systems

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67 (38.862228393555): select jos_linkedin.link from jos_linkedin where cat=10

68 (41.007995605469): SELECT fid FROM jos_deeppockets WHERE id=294731448 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294731448 AND published='1' LIMIT 1

69 (30.040740966797): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (180.00602722168): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731448 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (241.04118347168): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731448 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (298.02322387695): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (65.088272094727): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (51.021575927734): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731448 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (27.894973754883): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731448 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (30.994415283203): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (55.789947509766): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

105 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

106 (46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731448 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (42.915344238281): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731448 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 2130.0315856934): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

109 (544.07119750977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

110 (61.988830566406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731448 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (405.07316589355): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731448 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (549.0779876709): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (456.80999755859): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (122.0703125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

115 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

116 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

117 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

118 (79.154968261719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

119 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

120 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

121 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

122 (376.22451782227): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 227950.09613037): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 4207.1342468262): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731448 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731448 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 81849.098205566): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (303.03001403809): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (87.976455688477): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (216.00723266602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (80.108642578125): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (209.80834960938): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (928.16352844238): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (232.93495178223): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (144.95849609375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (393.15223693848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (319.00405883789): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (199.0795135498): SELECT name FROM jos_deeppockets WHERE id=213

138 (51.021575927734): SELECT name FROM jos_deeppockets WHERE id=213

139 (968.93310546875): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (751.97219848633): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (124.93133544922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

142 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

143 (!!!!! 12066.841125488): TRUNCATE TABLE jos_trademed_module

144 (228.8818359375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731448 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (92.983245849609): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731448 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 8001.8043518066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (178.09867858887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (122.0703125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

149 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

150 (!!!!! 1303.9112091064): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

152 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

153 (61.03515625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731448 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731448 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (40.054321289062): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (35.04753112793): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (49.114227294922): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (144.00482177734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

158 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731448 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731448 AND published='1' LIMIT 1

159 (158.07151794434): select jos_twitters.link from jos_twitters where cat=10

160 (46.968460083008): select jos_facebook.link from jos_facebook where cat=10

161 (42.915344238281): select jos_google_plus.link from jos_google_plus where cat=10

162 (38.862228393555): select jos_linkedin.link from jos_linkedin where cat=10

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