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Scientists Create, Watch Tumor-Fighting Immune Cells Attack Cancer

By MedImaging International staff writers
Posted on 10 Aug 2010

Researchers have created a large, well-stocked army of tumor-seeking immune system cells, which they could see in real time, using positron emission tomography (PET) imaging as the cellular payload traveled throughout the body to locate and attack deadly melanomas.

The gene therapy research, conducted with melanomas grown in mice, utilized an inactive HIV-like virus to serve as a vehicle to arm the lymphocytes with T cell receptors, which caused the lymphocytes to become specific killers of cancerous cells. A reporter gene, which glows "hot” during PET scanning, also was inserted into the cells so researchers could track the genetically engineered lymphocytes after they were injected into the blood stream, made their way to the lungs and lymph nodes, and then specifically homed in on the tumors wherever they were located within the body.

"We're trying to genetically engineer the immune system to become a cancer killer and then image how the immune system operates at the same time,” said Dr. Antoni Ribas, an associate professor of hematology/oncology, a researcher at the University of California, Los Angeles' (UCLA) Jonsson Comprehensive Cancer Center (USA) and the senior author of the study. "We knew this approach of arming the lymphocytes with T cell receptors showed significant antitumor activity based on studies in humans. Now, by tracking the immune system's reaction to cancer and imaging it in real time, we can project how the same process that succeeded in mice might behave in people.”

The study was published July 12, 2010, in the early online issue of the journal Proceedings of the [U.S.] National Academy of Sciences (PNAS). "The novelty of our work is that we were able to pack together the cancer specific T cell receptor and the PET reporter genes in a single vector and use it in mice with an intact immune system that closely resembles what we would see in real patients,” stated Dr. Richard Koya, an assistant professor of surgical oncology at UCLA's David Geffen School of Medicine, and first author of the study. "We were also gladly surprised to see the targeted tumors literally melt away and disappear, underscoring the power of the combined approach of immune and gene therapy to control cancer.”

The immune system typically does not recognize cancer cells in the body as enemies. The insertion of the antigen-specific T cell receptors--modified to seek out a tumor antigen on the surface of the melanoma cells--in effect uncovers the malignant cells, revealing them as lethal invaders that must be sought out and destroyed. By imaging the genetically modified T cells as they seek out and attack the cancer, the scientists can closely examine the processes of the immune system as it fights malignancies, which could then result in better monitoring response to therapy in melanoma patients.

In this study, the cells were injected into the bloodstreams of the mice, which were found to begin to fight the melanoma within two to three days. The mice were imaged periodically for 10 days to ensure the lymphocytes were indeed killing the cancer. The process to find and kill the malignant cells could take longer in people, according to Dr. Ribas.

If a patient's tumor did not respond well to the administration of the genetically engineered T cells, scientists could determine by PET scanning whether the cells had not successfully made it to the tumor site or, if they did arrive, whether or not they functioned as expected. Monitoring the immune response also could provide insights into ways to better engineer the lymphocytes to more effectively enter and attack the tumors.

In this study, about one million genetically engineered lymphocytes were created and injected into a mouse. In humans, the number of tumor-seeking cells needed to fight the cancer is approximately one billion, according to Dr. Ribas. He and his team are working now on creating a vector, or vehicle, to insert the T cell receptors and reporter gene into the lymphocytes in a way that is safe to use in humans. If all goes well, human studies of the process could begin in approximately one year, Dr. Ribas noted.

Related Links:
University of California, Los Angeles' Jonsson Comprehensive Cancer Center

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56 (64.13459777832): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

57 (76.055526733398): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730633 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

58 (334.9781036377): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730633 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (!!!!! 1108.8848114014): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

60 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

61 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

62 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

63 (81.777572631836): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (500.91743469238): SELECT fid FROM jos_deeppockets WHERE id=294730633 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294730633 AND published='1' LIMIT 1

65 (45.061111450195): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

66 (44.822692871094): select jos_twitters.link from jos_twitters where cat=10

67 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

68 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

69 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

70 (33.140182495117): SELECT fid FROM jos_deeppockets WHERE id=294730633 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294730633 AND published='1' LIMIT 1

71 (30.994415283203): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

72 (293.97010803223): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730633 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (339.98489379883): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730633 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (42.915344238281): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (50.783157348633): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (46.968460083008): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730633 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (29.087066650391): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730633 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (40.054321289062): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

107 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

108 (55.074691772461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730633 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (42.915344238281): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730633 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

111 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

112 (394.82116699219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730633 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (383.13865661621): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730633 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730631 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (328.06396484375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730631 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (577.92663574219): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (354.05158996582): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

119 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

120 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

121 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

122 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

123 (35.04753112793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

124 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

125 (35.04753112793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

126 (263.92936706543): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

127 (!!!!! 18701.791763306): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

128 (490.18859863281): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730633 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730633 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (147.10426330566): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (36.001205444336): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

132 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

133 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

134 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

135 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

136 (28.848648071289): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

137 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

138 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

139 (472.06878662109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (324.96452331543): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (43.153762817383): SELECT name FROM jos_deeppockets WHERE id=213

142 (31.948089599609): SELECT name FROM jos_deeppockets WHERE id=213

143 (535.01129150391): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (491.85752868652): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

145 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

146 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

147 (!!!!! 7730.9608459473): TRUNCATE TABLE jos_trademed_module

148 (105.85784912109): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730633 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730633 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

150 (885.96343994141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

152 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

153 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

154 (!!!!! 1267.9100036621): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

155 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

156 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

157 (39.815902709961): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730633 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730633 AND type='deeppockets_item' AND published='1' LIMIT 1

158 (37.908554077148): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

159 (38.862228393555): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

160 (46.968460083008): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

161 (351.1905670166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

162 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730633 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730633 AND published='1' LIMIT 1

163 (39.100646972656): select jos_twitters.link from jos_twitters where cat=10

164 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

165 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

166 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

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