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New Molecular Imaging Biomarker Effectively Demonstrates Malignant Prostate Tumors

By MedImaging International staff writers
Posted on 22 Jul 2010

Thomas Jefferson University (Philadelphia, PA, USA) and NuView Life Sciences (Park City, UT, USA) have entered into an exclusive licensing agreement for advancing the development of a new molecular imaging (MI) compound that identifies genomic expressions linked to prostate cancer (PC).

"The prostate compound developed at Thomas Jefferson University may provide a noninvasive early and more accurate imaging technique to (a) localize primary PC, that will guide biopsy; (b) detect recurrent disease; (c) image metastatic disease; and (d) determine effectiveness of treatment,” said Dr. Mathew Thakur, professor of radiology and director and lead investigator. Developments in genomics and proteomics have shed light on the genesis of many diseases, including PC. PC cells express oncogene product VPAC1 exogenously in a large number. These specific fingerprints express themselves at a very early stage, well before cell morphology has altered for histologic confirmation, and even well before the elevation of PSA [prostate-specific antigen]. We hypothesize that targeting elevated VPAC1 with gene-guided radioactive probe for molecular imaging of PC will permit us to contribute toward this need. During the past 10 years, the Thakur laboratory at Thomas Jefferson University has gained extensive experience in successfully targeting these biomarkers with Tc-99m or Cu-64 labeled specific peptides, for early and accurate diagnosis of pancreatic and breast cancers in animals as well as in humans by planar, SPECT [single photon emission tomography] and PET [positron emission tomography] imaging. The early data for PET imaging of PC by Cu-64-peptide are highly encouraging,” said Dr. Thakur.

Among men in the United States, PC is the most deadly disease, second only to the cancers of the lung and bronchus combined. Statistical data indicate that PC affects one male in every six who are older than 60 years of age and the risk continues to rise as life expectancy increases. Although great advances have been made in the diagnosis and treatment of PC, 29,500 men succumbed to PC in 2007 alone. Early diagnosis of PC can necessitate aggressive therapeutic intervention; greatly improve the management of disease, and save patients from morbidity and mortality. Two prominent diagnostic tests for PC, namely the determination of PSA and the transrectal ultrasound (TRUS), suffer from serious limitations and require invasive systemic biopsy for histologic confirmation, considered to be the gold standard. In 2007, an estimated 750,000 prostate biopsies were performed, more than two-thirds of which had benign pathology, leading to a major ineffectiveness. Inaccurate or unreliable diagnosis results in under-, or over-treatment of patients leading to minimal benefits, incontinence, and/or impotence and significant loss of health care resources.

NuView CEO Paul Crowe, said, "The benefits from this MI biomarker are clear. If potentially terminal conditions such as prostate cancer can be accurately detected before manifesting into a structural change, patient outcomes would greatly improve, and healthcare costs would decline. MI is noninvasive, so the need for exploratory surgery would also be reduced, and MI can be used to track the progress and response from drug therapies or other treatments, enabling the physician to monitor and quickly respond to their patient's condition.”

NuView medical director Peter Conti, M.D. added, "This development of genomics-based molecular imaging diagnostics is very promising and may, with alterations to the biomarkers original complex, become a companion or paired targeted therapeutic. The potential for pairing a molecular diagnostic and a targeted therapy based on the individual patient characteristics, will contribute to the growing trend towards more efficient personalized medicine. We are pleased to part of this new frontier in medicine that should provide physicians with new approaches for diagnosis and treatment of medical disorders.” Dr. Conti is a professor of biomedical engineering, radiology, and pharmacy at the University Of Southern California (Los Angeles, USA).

Related Links:
Thomas Jefferson University
NuView Life Sciences

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59 (!!!!! 7086.0385894775): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

60 (499.96376037598): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

61 (!!!!! 13759.851455688): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 4597.1870422363): SELECT fid FROM jos_deeppockets WHERE id=294730374 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294730374 AND published='1' LIMIT 1

63 (350.9521484375): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (873.80409240723): select jos_twitters.link from jos_twitters where cat=10

65 (267.02880859375): select jos_facebook.link from jos_facebook where cat=10

66 (36.001205444336): select jos_google_plus.link from jos_google_plus where cat=10

67 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

68 (344.03800964355): SELECT fid FROM jos_deeppockets WHERE id=294730374 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294730374 AND published='1' LIMIT 1

69 (189.06593322754): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (!!!!! 1240.0150299072): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730374 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (661.13471984863): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730374 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (58.889389038086): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (181.91337585449): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (!!!!! 4966.9742584229): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (!!!!! 3521.9192504883): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (984.19189453125): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (384.09233093262): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (598.90747070312): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (478.98292541504): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (135.18333435059): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (262.97569274902): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (222.92137145996): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (283.00285339355): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (97.990036010742): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (687.1223449707): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730374 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (211.00044250488): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730374 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (!!!!! 2940.1779174805): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 5383.9683532715): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (82.015991210938): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (201.94053649902): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (323.05717468262): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (192.88063049316): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (633.00132751465): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (142.09747314453): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (275.85029602051): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 2681.9705963135): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

105 (!!!!! 2310.037612915): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

106 (447.98851013184): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730374 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (72.956085205078): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730374 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 6550.0736236572): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

109 (402.92739868164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

110 (96.08268737793): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730374 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 1174.9267578125): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730374 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 2911.0908508301): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 6948.9479064941): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 7522.1061706543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

115 (!!!!! 5676.9847869873): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

116 (!!!!! 7472.038269043): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

117 (!!!!! 6392.0021057129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

118 (!!!!! 2928.0185699463): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

119 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

120 (836.84921264648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

121 (579.1187286377): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

122 (904.08325195312): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 54979.085922241): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 2711.0576629639): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730374 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730374 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 27009.010314941): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (735.04447937012): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 1543.9987182617): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (228.1665802002): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (!!!!! 2191.7819976807): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (216.00723266602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (632.04765319824): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (114.91775512695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (468.96934509277): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (601.05323791504): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 1579.9999237061): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (!!!!! 2663.8507843018): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (!!!!! 4087.9249572754): SELECT name FROM jos_deeppockets WHERE id=213

138 (211.95411682129): SELECT name FROM jos_deeppockets WHERE id=213

139 (787.01972961426): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (728.84559631348): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 1281.9766998291): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

142 (293.01643371582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

143 (!!!!! 11770.009994507): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 1404.0470123291): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730374 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (!!!!! 1049.0417480469): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730374 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 2142.9061889648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 1340.8660888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

149 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

150 (!!!!! 1276.969909668): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 2610.9218597412): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

152 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

153 (564.0983581543): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730374 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730374 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (43.869018554688): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (33.855438232422): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (123.02398681641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

158 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730374 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730374 AND published='1' LIMIT 1

159 (195.98007202148): select jos_twitters.link from jos_twitters where cat=10

160 (36.954879760742): select jos_facebook.link from jos_facebook where cat=10

161 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

162 (!!!!! 3290.1763916016): select jos_linkedin.link from jos_linkedin where cat=10

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