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Silicone Oil Helps Shield Vision During Radiation Therapy for Eye Cancer

By MedImaging International staff writers
Posted on 22 Jul 2010

A commonly used substance called silicone oil could protect vision in patients undergoing radiation therapy for ocular melanoma.

Researchers at the University of California, Los Angeles (UCLA; USA) examined several vitreous substitutes, including silicone oil, heavy oil, and perfluorocarbon (PFC) for their radiation attenuation properties from iodine 125, using both empirical measurement and theoretical calculation. In vitro and ex vivo cadaveric dosimetry measurements were obtained with thermo-luminescent dosimeters to demonstrate the attenuation effect during simulated plaque brachytherapy. The results showed that radiation attenuation using the silicone oil at distances corresponding to vital ocular structures achieved the best results, with a projected attenuation reaching as high as 57%.

Based on these results, the researchers developed a new surgical technique, which takes place immediately before the patient's eye is exposed to the radiation. The patients first undergo an exam to measure baseline vision before treatment. The surgeon next removes the vitreous gel, which supports the interior shape of the eye; the gel is replaced with silicon oil, a substance that is often used to hold the retina in place during surgery to repair retinal detachment. The surgeons then treat the ocular melanoma by stitching a gold plaque containing radioactive seeds to the sclera of the eye, removing it a few days later; after removing the radiation plaque from the treated eye, the oil is flushed away with saline, which is eventually replaced by the patient's natural fluids. The study was published in the July 2010 issue of Archives of Ophthalmology.

"Until recently, physicians focused on killing the tumor and considered vision loss secondary. Our results suggest that silicon oil offers a safe tool for protecting the patient's vision during radiation,” said lead author Tara McCannel, M.D., an assistant professor of ophthalmology and director of the UCLA ophthalmic oncology center. "The substance acts like a physical shield, reducing the amount of radioactive rays that reach the back and sides of the eye. We hope that silicon oil's ability to block radiation translates into better vision for patients down the road.”

While radiation treatment for ocular melanoma kills the cancer cells, it also causes irreversible injury to the optic nerve fibers and macula, the section of the retina responsible for central vision; the radiation damage to the macula also weakens the blood vessels supplying the eye. Even when the radiation treatment is successful, the eye structures remain extremely fragile and prone to atrophy, which can lead to subsequent vision loss.

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59 (!!!!! 1248.836517334): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

60 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

61 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

62 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

63 (112.05673217773): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (586.03286743164): SELECT fid FROM jos_deeppockets WHERE id=294730367 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294730367 AND published='1' LIMIT 1

65 (446.08116149902): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

66 (52.213668823242): select jos_twitters.link from jos_twitters where cat=10

67 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

68 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

69 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

70 (35.04753112793): SELECT fid FROM jos_deeppockets WHERE id=294730367 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294730367 AND published='1' LIMIT 1

71 (33.140182495117): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

72 (385.04600524902): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730367 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (255.10787963867): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730367 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (46.014785766602): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (72.002410888672): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (77.009201049805): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730367 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (40.054321289062): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730367 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (73.909759521484): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (87.976455688477): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (69.141387939453): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (101.80473327637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

107 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

108 (89.883804321289): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730367 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (52.928924560547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730367 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

111 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

112 (411.03363037109): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730367 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (392.91381835938): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730367 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (55.074691772461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730366 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (343.08433532715): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730366 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (586.03286743164): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (364.06517028809): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (146.15058898926): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

119 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

120 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

121 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

122 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

123 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

124 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

125 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

126 (362.87307739258): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

127 (!!!!! 21792.888641357): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

128 (605.10635375977): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730367 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730367 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 8265.0184631348): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (108.95729064941): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

132 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

133 (74.863433837891): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

134 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

135 (306.84471130371): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

136 (77.962875366211): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

137 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

138 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

139 (499.96376037598): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (385.99967956543): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (203.13262939453): SELECT name FROM jos_deeppockets WHERE id=213

142 (32.901763916016): SELECT name FROM jos_deeppockets WHERE id=213

143 (586.03286743164): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (515.93780517578): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

145 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

146 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

147 (!!!!! 10274.171829224): TRUNCATE TABLE jos_trademed_module

148 (108.00361633301): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730367 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730367 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

150 (578.88031005859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

152 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

153 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

154 (!!!!! 1259.0885162354): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

155 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

156 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

157 (41.961669921875): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730367 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730367 AND type='deeppockets_item' AND published='1' LIMIT 1

158 (33.855438232422): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

159 (33.140182495117): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

160 (50.783157348633): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

161 (124.93133544922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

162 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730367 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730367 AND published='1' LIMIT 1

163 (41.007995605469): select jos_twitters.link from jos_twitters where cat=10

164 (39.815902709961): select jos_facebook.link from jos_facebook where cat=10

165 (39.815902709961): select jos_google_plus.link from jos_google_plus where cat=10

166 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

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