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Molecular Imaging of Insulin Growth Factor 1 Receptor Expression Is Effective for Triple-Negative Breast Cancer

By MedImaging International staff writers
Posted on 25 May 2010

New research revealed the successful utilization of new in vivo positron emission tomography (PET) and single photon emission computed tomography (SPECT) molecular imaging techniques, in laboratory animals with triple-negative breast cancer, to enable better patient selection for targeted therapies.

The research was presented April 2010 at the 101st meeting of the American Association of Cancer Research in Washington, D.C., USA. The purpose of the study, conducted by researchers from Radboud University Nijmegen Medical Center (Nijmegen, The Netherlands), was to develop a noninvasive method of visualizing the insulin-like growth factor 1 receptor (IGF-1R), which is expressed by 30% - 40% of patients with triple-negative breast cancer, thus making them uniquely identifiable and able to be treated with IGF-1R antibodies.

"The use of molecular imaging techniques, such as PET and SPECT, has been helpful in the progression of our research toward finding molecular targets to visualize the IGF-1R, expressed by cells of patients with triple-negative breast cancer. In the future, the ability to visualize the receptor may enable more effective patient selection from the triple-negative breast cancer patient population for IGF-1R targeted therapy,” remarked Otto C. Boerman, of the department of nuclear medicine, Radboud University Medical Center, Nijmegen. Siemens Healthcare (Erlangen, Germany) Inveon PET and MILabs U-SPECT preclinical imagers were used in the in vivo portion of the study. Small animal PET, SPECT, and computed tomography (CT) molecular imaging provides quantitative insight into understanding tumor biology and can aid in the development of therapeutic options.

The researchers concluded that ¹¹¹In-R1507 SPECT and ⁸⁹Zr-R1507 PET are excellent methods to visualize IGF-1R expression in vivo in triple-negative breast cancer xenografts. The study results verified that ¹¹¹In-R1507 was slowly internalized by SUM149 cells and was accumulated specifically and efficiently in the SUM149 xenografts. The specific tumor uptake was reported at 20% ID/g, 33% ID/g, and 31% ID/g at one, three and seven days post injection, respectively. At the optimal dose for imaging, the tumor uptake was 35% ID/g and enabled clear visualization of the subcutaneous xenograft with increasing contrast at later time points.

The study was conducted using R1507, a monoclonal antibody directed against an epitope on the extracellular domain of the IGF-1R. It was radiolabeled with ¹¹¹Indium, ¹²⁵Iodine, and ⁸⁹Zirconium. In vitro, the affinity and internalization kinetics of ¹¹¹In-R1507 were determined using the IGF-1R expressing breast cancer cell line SUM149, which is estrogen receptor-, progesterone receptor-, and HER2 receptor-negative. In vivo studies were performed in BALB/c nude mice with subcutaneous SUM149 xenografts. To determine the pharmacodynamics of R1507, mice received an intravenous injection of ¹¹¹In-R1507 and ¹²⁵I-R1507. One, three, and seven days postinjection, ex vivo tumor uptake was measured. Nonspecific uptake was determined by coinjection of an excess unlabeled R1507. A dose escalation study was performed with ¹¹¹In-R1507 to determine the optimal protein dose of R1507 for in vivo imaging (dose range 1 µg - 1000 µg). Finally, PET and SPECT images were acquired of mice with subcutaneous SUM149 tumors one, three, and seven days postinjection of ⁸⁹Zr-R1507 and ¹¹¹In-R1507, respectively.

Related Links:
Radboud University Nijmegen Medical Center
Siemens Healthcare

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60 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

61 (242.94853210449): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 1278.8772583008): SELECT fid FROM jos_deeppockets WHERE id=294729491 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294729491 AND published='1' LIMIT 1

63 (96.797943115234): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (814.19944763184): select jos_twitters.link from jos_twitters where cat=10

65 (77.962875366211): select jos_facebook.link from jos_facebook where cat=10

66 (58.889389038086): select jos_google_plus.link from jos_google_plus where cat=10

67 (48.160552978516): select jos_linkedin.link from jos_linkedin where cat=10

68 (97.036361694336): SELECT fid FROM jos_deeppockets WHERE id=294729491 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294729491 AND published='1' LIMIT 1

69 (!!!!! 1585.9603881836): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (601.05323791504): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294729491 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (343.08433532715): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294729491 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (56.982040405273): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (108.95729064941): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (62.942504882812): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (110.14938354492): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (83.208084106445): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294729491 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (48.160552978516): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294729491 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (46.014785766602): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (93.936920166016): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (65.088272094727): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (81.062316894531): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (54.836273193359): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (59.843063354492): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (129.93812561035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

105 (130.89179992676): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

106 (96.08268737793): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294729491 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (!!!!! 7846.1170196533): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294729491 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (227.92816162109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

109 (101.80473327637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

110 (80.82389831543): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294729491 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (866.88995361328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294729491 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (830.88874816895): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (988.00659179688): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (907.18269348145): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

115 (339.98489379883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

116 (289.9169921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

117 (252.00843811035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

118 (300.88424682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

119 (255.10787963867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

120 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

121 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

122 (440.83595275879): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 66664.934158325): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (627.99453735352): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294729491 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294729491 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 35866.975784302): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (137.0906829834): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (96.797943115234): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (356.91261291504): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (43.153762817383): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (482.08236694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (!!!!! 1718.9979553223): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (66.041946411133): SELECT name FROM jos_deeppockets WHERE id=213

138 (28.133392333984): SELECT name FROM jos_deeppockets WHERE id=213

139 (710.01052856445): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (663.99574279785): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

142 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

143 (!!!!! 7611.9899749756): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 3233.1943511963): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294729491 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (156.87942504883): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294729491 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (670.9098815918): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

149 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

150 (!!!!! 1341.1045074463): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

152 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

153 (43.869018554688): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294729491 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294729491 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (40.054321289062): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (36.954879760742): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (51.021575927734): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (153.0647277832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

158 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729491 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729491 AND published='1' LIMIT 1

159 (!!!!! 1905.9181213379): select jos_twitters.link from jos_twitters where cat=10

160 (324.01084899902): select jos_facebook.link from jos_facebook where cat=10

161 (123.02398681641): select jos_google_plus.link from jos_google_plus where cat=10

162 (494.95697021484): select jos_linkedin.link from jos_linkedin where cat=10

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