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Collaboration Initiated for PET Imaging Agent Manufacturing

By MedImaging International staff writers
Posted on 20 May 2010

Imaging biomarker production is set to expand the availability of a molecular imaging agent for positron emission tomography (PET) imaging of beta-amyloid deposits in the brain, a key pathologic component of Alzheimer's disease (AD) for clinical studies in the United States.

Avid Radiopharmaceuticals, Inc. (Philadelphia, PA, USA) and PETNET Solutions, Inc. (Knoxville, TN, USA), a wholly-owned subsidiary of Siemens Medical Solutions, USA, Inc. (Ann Arbor, MI, USA), marked the first dose shipped from a PETNET Solutions manufacturing facility as part of its collaboration with Avid on Florbetapir F18 (18F-AV-45), Avid's molecular imaging agent PET imaging of beta-amyloid deposits.

Florbetapir is currently being evaluated for brain PET imaging of beta-amyloid in clinical studies of patients with suspected AD or mild cognitive impairment (MCI) in the United States and the European Union. PETNET Solutions operates the industry's largest network of PET biomarker-production facilities worldwide. PETNET manufactures Florbetapir at multiple facilities in the United States, and continues to expand production capabilities to support the clinical development of Florbetapir.

"We are very pleased to be able to expand our clinical trial program by working with Siemens and PETNET on the manufacturing of Florbetapir for supply of our clinical trial sites throughout the U.S.,” said Daniel M. Skovronsky, M.D., Ph.D., Avid's president and CEO. "This partnership allows us to accelerate the development of Florbetapir and to extend our existing collaborations within the Alzheimer's researcher community and the pharmaceutical industry, both of which are in pursuit of new tools for the early detection and management of Alzheimer's disease.”

Siemens Healthcare, molecular imaging CEO Britta Fuenfstueck commented, "Siemens and Avid are organizations committed to changing the way chronic diseases are diagnosed and managed. Together, we share the view that new PET molecular imaging agents, such as Florbetapir, could have a major impact on healthcare for our aging population. We are pleased to be working with Avid on this exciting development and believe it fits well with our mission to deliver, expand, and advance the science of molecular imaging to the benefit of health care providers and their patients.”

Avid's Florbetapir was the first beta-amyloid imaging compound to enter multicenter, IND (Investigational New Drug) clinical studies in the United States, and has now been studied in more than a dozen trials in subjects ranging from cognitively normal individuals to those with Alzheimer's dementia. A pivotal phase III registration study, which was initiated early last year in the United States is nearing completion, and the compound is currently in additional clinical studies in the European Union, South America, Australia, and Asia.

Avid Radiopharmaceuticals is a developer of molecular imaging products with the potential for earlier and more effective detection, diagnosis and monitoring of major chronic human diseases. The company is a pioneer in the development of molecular imaging agents for Alzheimer's disease that could lead to earlier diagnosis and better evaluation of drugs designed to prevent or reverse beta-amyloid plaque build-up in the brain. Avid is currently conducting phase III clinical studies of Florbetapir (18F-AV-45), for imaging beta-amyloid plaques in AD, and is in phase I and II trials with 18F-AV-133 for imaging the vesicular monoamine transporter (VMAT2) in diseases involving dopaminergic degeneration (Parkinson's disease and dementia with Lewy Bodies) and beta cell dysfunction (type I and type II diabetes mellitus).

The Siemens Healthcare Sector (Erlangen, Germany) is one of the world's largest suppliers to the healthcare industry and a trendsetter in medical imaging, laboratory diagnostics, medical information technology, and hearing aids.

Related Links:
Avid Radiopharmaceuticals
PETNET Solutions
Siemens Healthcare

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60 (!!!!! 8132.9345703125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

61 (132.79914855957): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 1175.8804321289): SELECT fid FROM jos_deeppockets WHERE id=294729442 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294729442 AND published='1' LIMIT 1

63 (77.962875366211): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (!!!!! 4409.0747833252): select jos_twitters.link from jos_twitters where cat=10

65 (66.995620727539): select jos_facebook.link from jos_facebook where cat=10

66 (47.922134399414): select jos_google_plus.link from jos_google_plus where cat=10

67 (40.054321289062): select jos_linkedin.link from jos_linkedin where cat=10

68 (656.1279296875): SELECT fid FROM jos_deeppockets WHERE id=294729442 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294729442 AND published='1' LIMIT 1

69 (69.141387939453): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (725.03089904785): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294729442 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (892.16232299805): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294729442 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (41.961669921875): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 2944.9462890625): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (102.04315185547): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (92.983245849609): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (114.91775512695): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294729442 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (56.982040405273): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294729442 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (59.843063354492): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 7405.9963226318): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (!!!!! 7968.9025878906): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (!!!!! 11827.945709229): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (!!!!! 7961.9884490967): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (!!!!! 7827.0435333252): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (!!!!! 15961.885452271): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (!!!!! 11736.869812012): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (!!!!! 7980.1082611084): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (!!!!! 7825.1361846924): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (!!!!! 7978.2009124756): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (!!!!! 7783.8897705078): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (!!!!! 7975.8167266846): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (!!!!! 3832.1018218994): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (!!!!! 7956.9816589355): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 7403.8505554199): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

105 (!!!!! 9591.817855835): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

106 (!!!!! 11934.995651245): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294729442 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (!!!!! 11929.035186768): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294729442 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 6896.0189819336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

109 (!!!!! 7971.0483551025): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

110 (164.98565673828): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294729442 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (809.90791320801): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294729442 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (898.83804321289): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (705.00373840332): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 2623.7964630127): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

115 (115.87142944336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

116 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

117 (49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

118 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

119 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

120 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

121 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

122 (550.0316619873): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 85363.864898682): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (588.89389038086): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294729442 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294729442 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 23025.989532471): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (82.015991210938): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (70.095062255859): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (50.067901611328): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (564.0983581543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (56.982040405273): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (526.90505981445): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (341.89224243164): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (267.02880859375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (66.041946411133): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 5839.1094207764): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (!!!!! 7930.9940338135): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (!!!!! 6445.8847045898): SELECT name FROM jos_deeppockets WHERE id=213

138 (!!!!! 9292.1257019043): SELECT name FROM jos_deeppockets WHERE id=213

139 (!!!!! 7885.9329223633): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (!!!!! 8028.9840698242): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 11485.09979248): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

142 (!!!!! 8018.970489502): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

143 (!!!!! 39551.019668579): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 6054.162979126): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294729442 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (!!!!! 3986.120223999): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294729442 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 1101.016998291): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (173.09188842773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (696.18225097656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

149 (75.817108154297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

150 (!!!!! 5967.8554534912): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (499.96376037598): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

152 (328.06396484375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

153 (319.00405883789): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294729442 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294729442 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (234.12704467773): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (46.968460083008): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (334.02442932129): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (613.92784118652): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

158 (238.18016052246): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294729442 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294729442 AND published='1' LIMIT 1

159 (!!!!! 3825.9029388428): select jos_twitters.link from jos_twitters where cat=10

160 (368.11828613281): select jos_facebook.link from jos_facebook where cat=10

161 (185.01281738281): select jos_google_plus.link from jos_google_plus where cat=10

162 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

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