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Imaging Method Designed to Stratify Breast Cancer Without Biopsy

By MedImaging International staff writers
Posted on 04 Jan 2010

Scientists have discovered a possible way for malignant breast tumors to be detected, without the need for a biopsy.

The study's findings were published online in December 2009 ahead of print in the Journal of Nuclear Medicine (JNM). Current imaging technologies miss up to 30 percent of breast cancers and cannot differentiate malignant tumors from benign tumors, thus requiring invasive biopsies. Approximately 5.6 million biopsies performed in the United States find only benign lesions. These biopsies cause considerable stress for the patients and have significantly high costs.

"The challenge has been to develop an imaging agent that will target a specific, fingerprint biomarker that visualizes malignant breast lesions early and reliably,” said Mathew Thakur, Ph.D., professor of radiology at Jefferson Medical College of Thomas Jefferson University (Philadelphia, PA, USA) and director of Radiopharmaceutical Research and Nuclear Medicine Research.

Dr. Thakur and colleagues evaluated an agent called ⁶⁴Cu-TP3805, which is used to evaluate tumors via positron emission tomography (PET) imaging. ⁶⁴Cu-TP3805 detects breast cancer by finding a biomarker called VPAC1, which is overexpressed as the tumor develops. The researchers compared the images using that agent with images using the gold standard imaging agent, ¹⁸F-FDG. They used MMTVneu mice, which are mice that develop breast tumors spontaneously, similar to humans. The mice first received a PET scan using the ¹⁸F-FDG. Then they received a computed tomography (CT) scan, and then they received another PET scan using ⁶⁴Cu-TP3805.

Ten tumors were detected on the mice. Four tumors were detected using both ¹⁸F-FDG and ⁶⁴Cu-TP3805, and four additional tumors were found with ⁶⁴Cu-TP3805 only. All eight of these tumors overexpressed the VPAC1 oncogene on tumor cells and were malignant by histology. The remaining two tumors were benign and were detected only with ¹⁸F-FDG. They did not express the VPAC1 oncogene, and therefore were not detected by the ⁶⁴Cu-TP3805.

"If this ability of ⁶⁴Cu-TP3805 holds up in humans, then in the future, PET scans with ⁶⁴Cu-TP3805 will significantly contribute to the management of breast cancer,” Dr. Thakur concluded.

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Jefferson Medical College of Thomas Jefferson University

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63 (77.009201049805): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (49.829483032227): select jos_twitters.link from jos_twitters where cat=10

65 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

66 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

67 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

68 (32.186508178711): SELECT fid FROM jos_deeppockets WHERE id=294727251 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294727251 AND published='1' LIMIT 1

69 (30.994415283203): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (864.98260498047): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294727251 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (376.22451782227): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294727251 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (77.009201049805): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 2075.9105682373): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (64.849853515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (!!!!! 3223.8960266113): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (84.877014160156): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (72.956085205078): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294727251 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (467.77725219727): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294727251 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (62.227249145508): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1201.1528015137): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

105 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

106 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294727251 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (555.99212646484): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294727251 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (138.99803161621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

109 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

110 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294727251 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (625.8487701416): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294727251 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (693.08280944824): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (389.09912109375): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

115 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

116 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

117 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

118 (49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

119 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

120 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

121 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

122 (427.9613494873): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 47236.919403076): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (658.98895263672): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294727251 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294727251 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 16123.056411743): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (61.03515625): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (50.067901611328): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (320.9114074707): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (653.98216247559): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (!!!!! 7925.0335693359): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (154.97207641602): SELECT name FROM jos_deeppockets WHERE id=213

138 (53.167343139648): SELECT name FROM jos_deeppockets WHERE id=213

139 (891.92390441895): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (550.0316619873): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

142 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

143 (!!!!! 13723.134994507): TRUNCATE TABLE jos_trademed_module

144 (102.04315185547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294727251 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294727251 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (582.93342590332): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

149 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

150 (!!!!! 5575.8953094482): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

152 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

153 (37.908554077148): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294727251 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294727251 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (33.140182495117): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (29.802322387695): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (31.948089599609): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

158 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294727251 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294727251 AND published='1' LIMIT 1

159 (36.954879760742): select jos_twitters.link from jos_twitters where cat=10

160 (28.133392333984): select jos_facebook.link from jos_facebook where cat=10

161 (29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10

162 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

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