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PET Imaging Agent for Alzheimer's Disease Provides Automated Measurement of Glucose Metabolism

By MedImaging International staff writers
Posted on 07 Oct 2009

A new diagnostic imaging advance allows the precise, automated measurement of glucose metabolism in the hippocampus, a brain structure that is crucial new memory formation and which is affected very early in Alzheimer's disease (AD).

The Alzheimer's Drug Discovery Foundation (ADDF; New York, NY, USA) is providing a grant of US$200,000 to Abiant Inc. (Deerfield, IL, USA) for the development of a highly accurate diagnostic imaging agent for AD. Abiant is focused on the application of neuroimaging to improve the diagnosis and treatment of neurologic and neuropsychiatric disorders.

Abiant's diagnostic approach combines key advances in the analysis of positron emission tomography (PET) images of the brain. The first of these was developed by Lisa Mosconi, Ph.D., Henry Rusinek, Ph.D., and Wai Tsui, M.S., from the New York University (NYU) School of Medicine's Center for Brain Health (New York, NY, USA), directed by Mony de Leon, Ed.D. Abiant is combining this with other major advances in statistical analysis tools that consolidate information from many regions in the brain into measurable patterns of disease progression. In studies using patients from academic centers worldwide, these approaches have been able to predict future decline, and to distinguish between types of dementia with very high accuracy.

"Abiant's diagnostic approach provides a potential path to clinician adoption and use of a powerful aid in early, accurate diagnosis that has not yet been achieved,” commented Howard Fillit, M.D., ADDF's executive director. "The grant will enable Abiant to further validate and translate its approaches toward a beneficial tool for the Alzheimer's disease community.”

"We are very pleased that ADDF is helping to fund our development efforts,” commented Dawn Matthews, chief executive officer of Abiant. "Not only will this help to accelerate our progress, but the ADDF will be a valuable partner in the guidance of our work toward broad clinical use.”

Dr. de Leon added, "PET imaging measurement of activity in the brain, and in particular the hippocampus, can provide a powerful biomarker for the early and accurate detection of Alzheimer's disease. We are very pleased to see this step toward the translation of our research advances to clinical use.”

ADDF's mission is to accelerate the discovery and development of drugs to prevent, treat, and cure Alzheimer's disease, related dementias, and cognitive aging. The organization awards grants to leading scientists conducting breakthrough drug-discovery research.

Abiant uses proprietary image analysis methods and software to provide sensitive biomarkers of drug effects and disease progression. This imaging information is intended to accelerate and improve accuracy of decision making in both disease diagnosis and drug development. Abiant has exclusively licensed technologies for accurate, automated measurement of information in PET images from NYU School of Medicine. The company conducts imaging studies on novel pharmaceutical compounds for drug development companies.

Related Links:
Alzheimer's Drug Discovery Foundation
Abiant
New York University School of Medicine

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63 (64.13459777832): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (68.902969360352): select jos_twitters.link from jos_twitters where cat=10

65 (37.908554077148): select jos_facebook.link from jos_facebook where cat=10

66 (41.007995605469): select jos_google_plus.link from jos_google_plus where cat=10

67 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

68 (46.014785766602): SELECT fid FROM jos_deeppockets WHERE id=294725785 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294725785 AND published='1' LIMIT 1

69 (43.869018554688): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (479.22134399414): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725785 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (350.9521484375): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725785 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (52.928924560547): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (75.101852416992): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (72.002410888672): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725785 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (42.915344238281): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725785 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (48.160552978516): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (73.909759521484): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (104.90417480469): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

105 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

106 (69.856643676758): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725785 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (63.896179199219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725785 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (99.18212890625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

109 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

110 (72.002410888672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294725785 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (725.03089904785): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294725785 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (724.07722473145): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (487.08915710449): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (163.07830810547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

115 (73.19450378418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

116 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

117 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

118 (79.154968261719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

119 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

120 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

121 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

122 (360.01205444336): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 27543.067932129): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (702.85797119141): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725785 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725785 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 10082.006454468): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (174.04556274414): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (83.208084106445): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (92.029571533203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (61.03515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (428.91502380371): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (70.810317993164): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (59.843063354492): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (464.91622924805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (318.05038452148): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (37.193298339844): SELECT name FROM jos_deeppockets WHERE id=213

138 (29.087066650391): SELECT name FROM jos_deeppockets WHERE id=213

139 (573.87351989746): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (451.80320739746): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

142 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

143 (!!!!! 8672.9526519775): TRUNCATE TABLE jos_trademed_module

144 (89.168548583984): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725785 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294725785 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (349.04479980469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

149 (47.206878662109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

150 (!!!!! 1122.9515075684): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

152 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

153 (37.908554077148): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294725785 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294725785 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (35.04753112793): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (32.186508178711): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (34.093856811523): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

158 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294725785 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294725785 AND published='1' LIMIT 1

159 (39.815902709961): select jos_twitters.link from jos_twitters where cat=10

160 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

161 (32.186508178711): select jos_google_plus.link from jos_google_plus where cat=10

162 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

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