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Clinical Trials Network Expands Phantom Program for Evaluating Imaging Centers

By MedImaging International staff writers
Posted on 12 May 2009

A prototype chest simulator is the first control implemented to ensure consistency across multiple imaging sites.

The SNM Clinical Trials Network (Reston, VA, USA) has reported that a prototype clinical positron emission tomography (PET) oncology imaging simulator--or "phantom"--has been successfully scanned and imaged at four imaging centers. SNM intends to deliver and scan the phantom at an additional 20 imaging centers by the end of September.

SNM's Clinical Trials Network--as part of its mission to ensure standardization and harmonization across multiple imaging sites participating in clinical trials--evaluates images produced by phantoms to ensure that molecular imaging centers are providing consistent and accurate images. Imaging consistency among sites--both in the technology used and images produced--is vital for ensuring quality imaging and quantitative data and is essential to meet U.S. Food and Drug Administration (FDA) requirements for investigational clinical trials.

"The community agrees that a lack of uniformity across imaging sites is a primary barrier to using imaging in clinical trials to facilitate drug development," said Michael Graham, Ph.D., M.D., cochair of SNM's Clinical Trials Network, and director of nuclear medicine at the University of Iowa Carver College of Medicine (Iowa City, USA). "When pharmaceutical companies apply to FDA for approval of a new product, they must first demonstrate a certain level of disease detectability as evidenced by some imaging measurement. Many of the denials of new drugs are based on a rejection of data compiled from poor-quality images or images that don't appear to match those from another similar study."

Effectively scanning phantoms is one part of the overall process that the network will use to "validate" imaging sites for future clinical trials. Imaging of the PET phantoms, which contain a known quantity and distribution of radioactivity, will be used to evaluate each site's imaging capabilities both qualitatively and quantitatively and ensure standardization and compliance with defined protocols in order to ensure consistency across multiple centers in a single trial.

"The network's phantom program draws upon an SNM phantom imaging program that has been operational for over 10 years. In addition, SNM maintains a group of experts who evaluate a center's image quality," said Paul E. Christian, chair of the Clinical Trials Network's Phantom Subcommittee and associate director of molecular imaging at the Huntsman Cancer Institute, University of Utah (Salt Lake City, USA). "Based on these phantom images, experts can help imaging centers by recommending adjustments in the image acquisition parameters to produce images of a very high quality."

The first phantom in use is the oncology phantom (designed primarily to support investigational oncology clinical trials), which was scanned at each of four test sites--the University of Utah, University of Iowa, University of Pennsylvania (Philadelphia, PA, USA), and Mayo Clinic (Rochester, MN, USA)--using a standard imaging protocol. To test the resolution of the imaging equipment at each site, the phantom contained multiple simulated tumors of different sizes. Physicians at each of the four sites were able to evaluate the images and identify all the tumors.

Based on this initial success with the oncology phantom, the network is expanding its phantom imaging program by providing other phantoms to qualified sites in the network's registry. In this regard, a cardiac phantom is beginning testing at the four initial sites, and a brain phantom prototype is being developed and is anticipated to be available by June 2009 to assist a pharmaceutical company with site imaging evaluation for an upcoming phase-3 clinical trial. These three phantoms will be on display at the MI Gateway in the exhibit hall during SNM's 56th annual meeting, June 13-17, 2009, in Toronto, Canada.

The SNM Clinical Trials Network has registered more than 200 imaging sites worldwide, with the goal of validating every site that has registered. As part of the registry, each validated site will undergo periodic retesting to ensure the continuing quality of performance.

SNM (formerly the Society of Nuclear Medicine) is an international scientific and medical organization dedicated to raising public awareness about what molecular imaging is and how it can help provide patients with the best health care possible. SNM members specialize in molecular imaging, a vital element of today's medical practice that adds an additional dimension to diagnosis, changing the way common and devastating diseases are understood and treated. SNM's more than 17,000 members set the standard for molecular imaging and nuclear medicine practice by creating guidelines, sharing information through journals and meetings, and leading advocacy on key issues that affect molecular imaging and therapy research and practice.

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57 (!!!!! 1405.0006866455): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

58 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

59 (115.87142944336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

60 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

61 (176.90658569336): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (657.08160400391): SELECT fid FROM jos_deeppockets WHERE id=294723167 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294723167 AND published='1' LIMIT 1

63 (458.0020904541): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (91.791152954102): select jos_twitters.link from jos_twitters where cat=10

65 (31.948089599609): select jos_facebook.link from jos_facebook where cat=10

66 (77.009201049805): select jos_google_plus.link from jos_google_plus where cat=10

67 (42.915344238281): select jos_linkedin.link from jos_linkedin where cat=10

68 (46.014785766602): SELECT fid FROM jos_deeppockets WHERE id=294723167 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294723167 AND published='1' LIMIT 1

69 (57.220458984375): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (883.81767272949): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723167 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (438.92860412598): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723167 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (75.101852416992): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (77.962875366211): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (76.055526733398): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723167 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (35.04753112793): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723167 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (43.153762817383): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 3596.0674285889): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (124.93133544922): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (95.129013061523): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (158.07151794434): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

105 (80.82389831543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

106 (101.08947753906): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723167 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (745.05805969238): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723167 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (176.90658569336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

109 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

110 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294723167 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (712.87155151367): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294723167 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (836.84921264648): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (515.93780517578): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 1895.9045410156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

115 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

116 (124.93133544922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

117 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

118 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

119 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

120 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

121 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

122 (508.06999206543): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 48485.994338989): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (562.90626525879): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723167 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723167 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 14837.980270386): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (236.98806762695): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 3465.8908843994): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (461.81678771973): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (50.067901611328): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 1127.0046234131): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (439.88227844238): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (358.10470581055): SELECT name FROM jos_deeppockets WHERE id=213

138 (35.04753112793): SELECT name FROM jos_deeppockets WHERE id=213

139 (857.11479187012): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (630.85556030273): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (256.06155395508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

142 (169.99244689941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

143 (!!!!! 18355.846405029): TRUNCATE TABLE jos_trademed_module

144 (167.8466796875): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723167 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (356.91261291504): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723167 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (931.97822570801): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (559.80682373047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

149 (254.86946105957): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

150 (!!!!! 2110.9580993652): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

152 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

153 (132.08389282227): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723167 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723167 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (164.03198242188): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

158 (153.0647277832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723167 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723167 AND published='1' LIMIT 1

159 (59.127807617188): select jos_twitters.link from jos_twitters where cat=10

160 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

161 (28.133392333984): select jos_google_plus.link from jos_google_plus where cat=10

162 (28.133392333984): select jos_linkedin.link from jos_linkedin where cat=10

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