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Molecular Imaging Enables Earlier, Individualized Treatment of Thyroid Cancer

By MedImaging International staff writers
Posted on 27 Jan 2009

In a study to determine the diagnostic benefits of molecular imaging in nodal staging of patients with thyroid cancer, researchers were able for the first time to effectively distinguish between cancerous cells in regional lymph nodes and normal residual thyroid tissue directly after surgery.

Researchers from the University of Erlangen-Nuremberg (Germany) reported in an article in the January 2009 issue of The Journal of Nuclear Medicine (JNM) on the findings of a study using a hybrid single photon emission computed tomography-computed tomography (SPECT-CT) system to determine and locate the metastasis of cancer cells to nearby lymph nodes.

According to the researchers, the demonstration or exclusion of cancer spread in regional lymph nodes plays a major role in treating the disease since all patients with lymph node metastases are considered to be at high risk for recurrence.

Currently, patients with differentiated thyroid carcinoma (DTC) who have had their thyroid removed are treated with radioactive iodine, which effectively hones in on and kills any remaining cancerous thyroid cells. Because one of the functions of the thyroid gland is to absorb iodine from the blood, radioiodine is taken up by any thyroid tissue not removed by surgery, including cancerous cells spreading to other body areas, such as lymph nodes. In addition to emitting electrons that destroy the tissue harboring the radionuclide, radioactive iodine emits photons suitable for imaging.

"Normal thyroid tissue as well as residual cancer cells concentrate radioiodine. Performed after ingestion of radioiodine, SPECT-CT provides three-dimensional images of the distribution of the radionuclide in the human body and is therefore used for staging this type of cancer,” said Torsten Kuwert, M.D., coauthor of the study. "Incorporated at first treatment, SPECT-CT allows us to better stratify patients into treatment groups.”

In the study, 57 patients received radioiodine therapy. After that, a SPECT-CT camera was rotated around the patients at a variety of angles to capture where the radioactivity was occurring. SPECT imaging can locate cells in the body that are not behaving normally, but does not provide the detailed, X-ray-like images that CT imaging can. The hybrid camera, however, is able to reveal both the malignant cell activity and the exact anatomical location.

"With SPECT-CT imaging, we were able to determine tumor spread much earlier than before,” said Daniela Schmidt, M.D., another coauthor of the article. "Earlier detection will lead to earlier individualized treatment of this potentially deadly cancer.”

The researchers also reported that this information led to a revision of the original diagnosis in 35% of the study participants. The images reclassified as benign 6 of 11 lesions that had been considered lymph node metastases and 11 of 15 lesions considered to be indeterminate.

"Our data suggest that SPECT-CT should be used as a routine procedure in DTC patients at the first radioiodine treatment,” said Dr. Kuwert. "By upstaging or downstaging disease, this hybrid imaging tool may alter the management of more than one-third of patients with the disease.”

According to the American Cancer Society, DTC is the most common form of thyroid cancer and one of the success stories in the war on cancer. Since the advent of radioiodine therapy, it has been considered one of the more curable of cancers.

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62 (564.0983581543): SELECT fid FROM jos_deeppockets WHERE id=294721835 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294721835 AND published='1' LIMIT 1

63 (57.93571472168): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (54.836273193359): select jos_twitters.link from jos_twitters where cat=10

65 (57.220458984375): select jos_facebook.link from jos_facebook where cat=10

66 (45.061111450195): select jos_google_plus.link from jos_google_plus where cat=10

67 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

68 (33.855438232422): SELECT fid FROM jos_deeppockets WHERE id=294721835 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294721835 AND published='1' LIMIT 1

69 (33.855438232422): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (393.15223693848): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294721835 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (355.95893859863): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294721835 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (68.902969360352): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (81.062316894531): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (45.7763671875): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (92.029571533203): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (80.108642578125): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294721835 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (33.855438232422): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294721835 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (36.001205444336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (59.127807617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (101.08947753906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

105 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

106 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721835 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (66.041946411133): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721835 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

109 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

110 (55.074691772461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294721835 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (649.92904663086): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294721835 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (711.91787719727): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (440.12069702148): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (111.10305786133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

115 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

116 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

117 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

118 (80.82389831543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

119 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

120 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

121 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

122 (343.08433532715): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 21018.028259277): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (504.0168762207): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294721835 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294721835 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 8229.0172576904): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (116.10984802246): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (39.815902709961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (77.009201049805): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (43.869018554688): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (391.96014404297): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (81.062316894531): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (54.836273193359): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (661.84997558594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (590.08598327637): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (58.174133300781): SELECT name FROM jos_deeppockets WHERE id=213

138 (43.869018554688): SELECT name FROM jos_deeppockets WHERE id=213

139 (803.94744873047): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (692.12913513184): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

142 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

143 (!!!!! 8351.0875701904): TRUNCATE TABLE jos_trademed_module

144 (110.14938354492): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721835 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (59.843063354492): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721835 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (918.86520385742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

149 (47.206878662109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

150 (!!!!! 1219.0341949463): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

152 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

153 (41.007995605469): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294721835 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294721835 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (35.04753112793): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (33.140182495117): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (34.809112548828): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

158 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721835 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721835 AND published='1' LIMIT 1

159 (46.014785766602): select jos_twitters.link from jos_twitters where cat=10

160 (32.186508178711): select jos_facebook.link from jos_facebook where cat=10

161 (34.093856811523): select jos_google_plus.link from jos_google_plus where cat=10

162 (31.948089599609): select jos_linkedin.link from jos_linkedin where cat=10

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