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Improved Method Determines Structure in Membrane Proteins

By MedImaging International staff writers
Posted on 10 Sep 2008

Determining the shape and function of specific proteins in the human body is becoming faster and easier, due to recent advancements.

By integrating custom-built spectrometers, innovative probe designs, and faster pulse sequences, a team led by the University of Illinois at Urbana-Campaign (IL, USA) chemistry professor Dr. More...

Chad Rienstra has developed unique capabilities for probing protein chemistry and structure through the use of solid-state nuclear magnetic resonance spectroscopy.

The researchers' recent findings represent considerable progress toward atomic-scale resolution of protein structure by solid-state nuclear magnetic resonance (NMR) spectroscopy. The technique can be applied to a large range of membrane proteins and fibrils, which, because they are not water-soluble, are frequently not amenable to more traditional solution-NMR spectroscopy or X-ray crystallography. "In our experiments, we explore couplings between atoms in proteins,” Dr. Rienstra said. "Our goal is to translate genomic information into high-resolution structural information, and thereby be able to better understand the function of the proteins.”

Solid-state NMR spectroscopy relaxes the need for solubility of the sample. In solution NMR spectroscopy, molecules are allowed to tumble randomly in the magnetic field. In solid-state NMR spectroscopy, molecules are immobilized within a small cylinder called a rotor. The rotor is then spun at high speed in the magnetic field. "With increased speed and sensitivity, we can obtain very high resolution spectra,” Dr. Rienstra said. "And, because we can resolve thousands of signals at a time--one for each atom in the sample--we can determine the structure of the entire protein.”

To improve sensitivity and accelerate data collection, Dr. Rienstra's group is developing smaller rotors that can be spun at rates exceeding 25,000 rotations per second. The faster rotation rate and smaller sample size allows the researchers to obtain more data in less time, and solve structure with just a few milligrams of protein.

The determination of protein structure benefits not only from improvements in technology, but also from the researchers' novel approach to refining geometric parameters. Structure determination is typically based upon distances between atoms. Dr. Rienstra discovered a way of measuring both the distance between atoms and their relative orientations with very high precision. "Using this technique, we can more precisely define the fragments of the molecule, and how they are oriented,” Dr. Rienstra commented. "That allows us to define protein features and determine structure at the atomic scale.”

Dr. Rienstra presented his group's latest findings and techniques at the national meeting of the American Chemical Society, held in Philadelphia, PA, USA, August 17-21, 2008. Dr. Rienstra and his collaborators also described their work--creating the highest resolution protein structure solved by solid-state NMR--in the March 25, 2008, issue of the journal Proceedings of the [U.S.] National Academy of Sciences (PNAS).

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University of Illinois at Urbana-Campaign

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57 (51.021575927734): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

58 (63.896179199219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294720296 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (503.0632019043): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294720296 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

60 (!!!!! 1405.9543609619): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

61 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

62 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

63 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

64 (119.92454528809): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

65 (665.18783569336): SELECT fid FROM jos_deeppockets WHERE id=294720296 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294720296 AND published='1' LIMIT 1

66 (51.021575927734): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

67 (46.968460083008): select jos_twitters.link from jos_twitters where cat=10

68 (31.948089599609): select jos_facebook.link from jos_facebook where cat=10

69 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

70 (31.948089599609): select jos_linkedin.link from jos_linkedin where cat=10

71 (36.001205444336): SELECT fid FROM jos_deeppockets WHERE id=294720296 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294720296 AND published='1' LIMIT 1

72 (33.855438232422): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

73 (425.10032653809): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294720296 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (313.99726867676): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294720296 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (46.014785766602): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

76 (82.969665527344): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (79.870223999023): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294720296 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (34.093856811523): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294720296 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (35.04753112793): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

93 (81.062316894531): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

108 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

109 (87.02278137207): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294720296 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294720296 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

112 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

113 (502.10952758789): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294720296 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (520.22933959961): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294720296 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (67.949295043945): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294720294 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (413.89465332031): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294720294 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

117 (828.98139953613): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (581.97975158691): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

119 (180.95970153809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

120 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

121 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

122 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

123 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

124 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

125 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

126 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

127 (378.13186645508): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

128 (!!!!! 22558.927536011): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

129 (499.96376037598): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294720296 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294720296 AND type='deeppockets_item' AND published='1' LIMIT 1

130 (!!!!! 7622.9572296143): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (77.009201049805): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

132 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

133 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

134 (44.822692871094): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

135 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

136 (420.09353637695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

137 (66.995620727539): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

138 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

139 (29.802322387695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

140 (489.95018005371): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (368.11828613281): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

142 (55.074691772461): SELECT name FROM jos_deeppockets WHERE id=213

143 (40.054321289062): SELECT name FROM jos_deeppockets WHERE id=213

144 (746.9654083252): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

145 (555.99212646484): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

146 (86.784362792969): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

147 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

148 (!!!!! 8476.9725799561): TRUNCATE TABLE jos_trademed_module

149 (118.01719665527): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294720296 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

150 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294720296 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

151 (!!!!! 1034.0213775635): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

152 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

153 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

154 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

155 (!!!!! 1312.0174407959): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

156 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

157 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

158 (41.961669921875): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294720296 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294720296 AND type='deeppockets_item' AND published='1' LIMIT 1

159 (35.04753112793): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

160 (32.186508178711): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

161 (46.014785766602): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

162 (167.8466796875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

163 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720296 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720296 AND published='1' LIMIT 1

164 (73.909759521484): select jos_twitters.link from jos_twitters where cat=10

165 (43.869018554688): select jos_facebook.link from jos_facebook where cat=10

166 (41.007995605469): select jos_google_plus.link from jos_google_plus where cat=10

167 (44.822692871094): select jos_linkedin.link from jos_linkedin where cat=10

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