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Trial Initiated to Evaluate Compound for Molecular Imaging of Apoptosis

By MedImaging International staff writers
Posted on 28 Aug 2008

New imaging compounds have shown selective uptake in apoptotic cells in a variety of disease models, including solid tumors undergoing radio- and chemotherapy, different ischemic and inflammatory conditions, neurodegenerative disorders, atherosclerosis, acute myocardial infarction and others. More...

NST NeuroSurvival Technologies, Ltd. (NST; Petach Tikva, Israel), a clinical phase company developing molecular imaging agents and drugs that identify and target cells undergoing apoptosis, recently announced that the U.S. Food and Drug Administration (FDA) issued a "safe to proceed” letter for the company's Aposense [18F]-ML-10 Investigational New Drug Application (IND).

[18F]-ML-10 is a member of the Aposense family of molecules, a novel class of small molecular probes that detect and accumulate within cells undergoing apoptosis from its early stages. Apoptosis is a genetically controlled process of cell death, associated with most medical disorders, in multiple clinical areas including oncology, neurology, and cardiology. Upon recognizing apoptosis-specific changes on the cell membrane, Aposense molecules undergo a change enabling them to enter and accumulate within the dying cell from the early stages of the death process, while being excluded from viable or necrotic cells. The [18F]-ML-10 is labeled with the radioisotope 18F(fluorodeoxyglucose) for molecular imaging of programmed cell death in real time with positron emission tomography (PET).

Molecular imaging is an emerging field that aims to visualize noninvasively biologic processes in vivo. The ability to image disease-related biologic processes might allow physicians to detect disease early, characterize the disease better, and to personalize treatment by real-time monitoring of therapeutic effect. Molecular imaging depends on special molecules (probes) that can selectively target these biologic processes, while carrying an imaging moiety for visualization, such as 18F or other positron-emitting radioisotopes that can be visualized by PET imaging.

Apoptosis is a genetically controlled program of cell death, inherent in any nucleated cell in the body, and therefore, frequently referred to as "cell suicide.” Upon activation, the apoptotic program executes a well-characterized sequence of events by which the cell undergoes fragmentation and elimination by macrophages, without damaging the surrounding tissue. Apoptosis is a universal process of cell death and it plays a role in most medical disorders, making it one of the important processes of cell biology. For example, apoptosis has important roles in oncology, both in the process of tumor growth, as well as in treatment with most therapies that aim to induce death in cancer cells. Targeting cells undergoing apoptosis, for imaging or delivering therapy, can therefore have broad clinical applications.

"This is a major step for our company as we now can expand our Aposense clinical program into the largest healthcare market in the world,” said Yoram Ashery, CEO of NST NeuroSurvival Technologies. "Initial clinical data for our [18F]-ML-10 compound for molecular imaging of apoptosis suggest that we may be able to deliver on the promise of personalized medicine by using real-time images of cell death to monitor disease activity and patient response to treatment.”

Pre-clinical studies with [18F]-ML-10 and other Aposnese compounds showed selective uptake in apoptotic cells in a variety of disease models. A phase I clinical study conducted in Europe evaluated the safety, dosimetry, and biodistribution of [18F]-ML-10 in normal healthy volunteers, and its suitability for imaging of cell death in the region of the infarct in patients with acute ischemic cerebral stroke. In both parts of the study, [18F]-ML-10 manifested an excellent safety profile and efficacy in imaging cell death. A phase IIa study was recently initiated in Israel in patients with metastatic brain tumors, a serious complication found in up to 25% of patients with advanced cancer. The study evaluates [18F]-ML-10 in early assessment of response to radiotherapy, compared to magnetic resonance imaging (MRI), which typically can evaluate response only two months or longer after treatment has been completed.

Following the FDA's safe-to-proceed letter for the [18F]-ML-10 IND, NST will expand its clinical programs in neurovascular disorders and cancer into the U.S. The first protocol already submitted to the FDA evaluates [18F]-ML-10 in visualizing apoptosis and neurovascular damage in patients with relapsing-remitting multiple sclerosis, as well as the safety of administering [18F]-ML-10. NST intends to submit additional protocols in the near term for evaluating [18F]-ML-10 in detecting and monitoring tumor response to anticancer therapy.

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50 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

51 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

52 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

53 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

54 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

55 (322.81875610352): SELECT name FROM jos_deeppockets WHERE id=294720132 LIMIT 1

56 (201.94053649902): SELECT name FROM jos_deeppockets_archive WHERE id=294720132 LIMIT 1

57 (57.93571472168): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

58 (66.041946411133): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294720132 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (421.04721069336): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294720132 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

60 (!!!!! 1398.0865478516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

61 (!!!!! 7812.0231628418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

62 (105.14259338379): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

63 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

64 (128.03077697754): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

65 (597.95379638672): SELECT fid FROM jos_deeppockets WHERE id=294720132 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294720132 AND published='1' LIMIT 1

66 (72.956085205078): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

67 (59.127807617188): select jos_twitters.link from jos_twitters where cat=10

68 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

69 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

70 (31.948089599609): select jos_linkedin.link from jos_linkedin where cat=10

71 (32.901763916016): SELECT fid FROM jos_deeppockets WHERE id=294720132 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294720132 AND published='1' LIMIT 1

72 (35.04753112793): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

73 (351.90582275391): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294720132 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (330.92498779297): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294720132 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (54.836273193359): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

76 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (291.82434082031): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294720132 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (51.975250244141): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294720132 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (39.815902709961): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

93 (79.870223999023): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (45.7763671875): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (110.86463928223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

108 (105.85784912109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

109 (95.129013061523): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294720132 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (72.956085205078): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294720132 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (101.08947753906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

112 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

113 (578.16505432129): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294720132 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (626.0871887207): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294720132 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (85.115432739258): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294720130 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (540.01808166504): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294720130 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

117 (638.96179199219): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (422.00088500977): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

119 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

120 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

121 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

122 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

123 (47.206878662109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

124 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

125 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

126 (35.04753112793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

127 (297.06954956055): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

128 (!!!!! 21245.956420898): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

129 (635.86235046387): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294720132 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294720132 AND type='deeppockets_item' AND published='1' LIMIT 1

130 (!!!!! 7915.0199890137): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (118.97087097168): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

132 (55.074691772461): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

133 (33.855438232422): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

134 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

135 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

136 (370.97930908203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

137 (87.02278137207): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

138 (43.153762817383): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

139 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

140 (496.86431884766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (308.03680419922): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

142 (37.908554077148): SELECT name FROM jos_deeppockets WHERE id=213

143 (31.948089599609): SELECT name FROM jos_deeppockets WHERE id=213

144 (623.94142150879): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

145 (475.88348388672): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

146 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

147 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

148 (!!!!! 9613.037109375): TRUNCATE TABLE jos_trademed_module

149 (129.93812561035): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294720132 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

150 (57.93571472168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294720132 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

151 (720.97778320312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

152 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

153 (86.784362792969): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

154 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

155 (!!!!! 1555.9196472168): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

156 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

157 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

158 (59.127807617188): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294720132 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294720132 AND type='deeppockets_item' AND published='1' LIMIT 1

159 (51.021575927734): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

160 (47.922134399414): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

161 (68.187713623047): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

162 (432.01446533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

163 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294720132 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294720132 AND published='1' LIMIT 1

164 (36.954879760742): select jos_twitters.link from jos_twitters where cat=10

165 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

166 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

167 (41.007995605469): select jos_linkedin.link from jos_linkedin where cat=10

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