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Research Breakthroughs in Imaging Biomarker Technology

By MedImaging staff writers
Posted on 30 Jul 2008

While currently the largest distributor of positron emission tomography (PET) radiopharmaceuticals in the United States and expanding internationally into countries and regions, such as India, the United Kingdom, Korea, and Australia, Siemens Healthcare (Erlangen, Germany) is also making progress into developing new imaging biomarkers that may be used in the future.

Siemens Molecular Imaging Biomarker Research facility, located in Los Angeles, CA, USA, has recently submitted an Investigational New Drug (IND) application for a new imaging agent that will help with imaging hypoxic tumors, which may be resistant to standard treatment involving chemotherapy. This type of imaging biomarker may be valuable in managing the treatment options for cancer patients.

Siemens also recently announced that the U.S. National Cancer Institute (NCI) has filed a cross-reference letter to a Type II Drug Master File that Siemens submitted to the U.S. Food and Drug Administration for its investigational 3'Deoxy-3'[18F] fluorothymidine (F-18 FLT) imaging biomarker. The cross reference allows F-18 FLT to be produced by Siemens/PETNET and used by any principle investigator in an NCI multicenter clinical trial. Moreover, the imaging biomarker will be available to independent investigators if they receive NCI approval. F-18 FLT is produced by Siemens Molecular Imaging Biomarker Research and PETNET Solutions, subsidiaries of Siemens Medical Solutions USA, Inc. The imaging biomarker has been used in studies monitoring the proliferative activity of cancer cells and it is currently being used in phase I clinical trials at several research sites.

Siemens Molecular Imaging (MI) University provides a substantive training resource for Siemens' customers. Designed to be used by the interpreting physician, referring physician, and technologist, MI University demonstrates the benefits of hybrid PET-computed tomography (CT) and single photon emission tomography- (SPECT)-CT systems, including when and how hybrid imaging influences patient management, through access to valuable clinical data and detailed case studies; video lectures; product information; and a tool for information exchange among peers

Siemens Healthcare is one of the world's largest suppliers to the healthcare industry. The company is a medical solutions provider with core competence in diagnostic and therapeutic technologies as well as in knowledge engineering, including information technology and system integration. With its laboratory diagnostics acquisitions, Siemens Healthcare is a fully integrated diagnostics company, bringing together imaging and lab diagnostics, therapy, and healthcare information technology solutions, supplemented by consulting and support services.

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Siemens Molecular Imaging
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68 (30.994415283203): SELECT fid FROM jos_deeppockets WHERE id=293310000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=293310000 AND published='1' LIMIT 1

69 (102.04315185547): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (739.09759521484): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=293310000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (303.03001403809): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=293310000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (39.100646972656): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (24.080276489258): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (38.14697265625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=293310000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (27.179718017578): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=293310000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (29.802322387695): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (657.08160400391): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (49.829483032227): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (843.04809570312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

105 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

106 (54.121017456055): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=293310000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (65.088272094727): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=293310000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

109 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

110 (81.062316894531): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=293310000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (331.87866210938): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=293310000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (534.0576171875): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (344.99168395996): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

115 (44.822692871094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

116 (45.7763671875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

117 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

118 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

119 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

120 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

121 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

122 (274.8966217041): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 32991.170883179): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (556.94580078125): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=293310000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=293310000 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 15090.942382812): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (69.856643676758): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (313.04359436035): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (26.941299438477): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (338.07754516602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (235.08071899414): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (190.01960754395): SELECT name FROM jos_deeppockets WHERE id=213

138 (33.140182495117): SELECT name FROM jos_deeppockets WHERE id=213

139 (554.08477783203): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (513.07678222656): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

142 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

143 (!!!!! 6440.1626586914): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 1577.8541564941): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=293310000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (74.148178100586): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=293310000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (340.93856811523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (138.99803161621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

149 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

150 (!!!!! 1096.0102081299): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

152 (48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

153 (46.014785766602): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=293310000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=293310000 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (26.941299438477): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (35.04753112793): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (127.07710266113): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

158 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=293310000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=293310000 AND published='1' LIMIT 1

159 (41.007995605469): select jos_twitters.link from jos_twitters where cat=10

160 (28.848648071289): select jos_facebook.link from jos_facebook where cat=10

161 (26.941299438477): select jos_google_plus.link from jos_google_plus where cat=10

162 (27.179718017578): select jos_linkedin.link from jos_linkedin where cat=10

163 (380.03921508789): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1077.8903961182): insert into jos_banners_delta values (14615,'2025-08-23 03:24:49','216.73.216.171','view'),(14202,'2025-08-23 03:24:49','216.73.216.171','view'),(14203,'2025-08-23 03:24:49','216.73.216.171','view')

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