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Heat Combined with Radiation Makes Tumor Cells Easier to Destroy

By MedImaging staff writers
Posted on 27 May 2008

Image: Computer artwork of two chromosomes highlighted where the telomeres are located (Photo courtesy of Hybrid Medical Animation).

Tumors have a unique vulnerability that can be exploited to make them more sensitive to heat and radiation, researchers recently reported. Radiation oncology researchers discovered that tumors have a built-in mechanism that protects them from heat (hyperthermia) damage and most probably decreases the benefit of hyperthermia and radiation as a combined therapy.

By interfering with that protection, researchers from Washington University School of Medicine in St. Louis (MO, USA) have shown that tumor cells grown in culture can be made more sensitive to hyperthermia-enhanced radiation therapy.

Radiation therapy is a mainstay of cancer treatment but does not always totally control tumors. For several years, raising tumor temperature has been investigated as a radiation therapy enhancer with few adverse side effects. "Past research has shown that hyperthermia is one of the most potent ways to increase cell-killing by radiation,” said senior author Tej K. Pandita, Ph.D., associate professor of radiation oncology and of genetics and a researcher with the Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital. "But now we've found that heat also enhances the activity of an enzyme called telomerase in cancer cells. Telomerase helps protect the cells from stress-induced damage and allows some of them to survive. We used compounds that inhibit telomerase and showed that cancer cells then become easier to destroy with hyperthermia and radiation used in combination.”

Telomerase repairs the ends of chromosomes by maintaining stability of specialized cellular structures called telomeres after cells divide. Without telomerase, the number of cell divisions is limited. Telomerase is not active in most normal human cells but is active in most cancer cells, which rely on telomerase to continue to proliferate.

In this study, Dr. Pandita's research group found that moderately increasing the heat also increases the activity of telomerase in tumor cells. The researchers found that if they inactivated telomerase and then increased the temperature of tumor cells, more cells were killed by ionizing radiation. Because nearly all cancers have telomerase, drugs that inactivate its activity could be useful against many cancers.

The researchers evaluated three compounds, and one, GRN163L, more strongly suppressed telomerase than the others. Many groups are studying GRN163L as an anticancer therapeutic agent, and it recently received clearance by the U.S. Food and Drug Administration (FDA) to enter human phase I/II clinical testing in chronic lymphocytic leukemia patients. In some preliminary studies, GRN163L has been shown to be additive when used in combination with existing cancer drugs or radiation.

Next, Dr. Pandita and colleagues will assess the effect of GRN163L on tumors in mice to see if it will enhance the cell-killing effect of hyperthermia and radiation. They are also working to develop chemicals that have heat-like effects to bypass the need to supply a physical heat source to tissue.

The study was published in the May 1, 2008, issue of the journal Cancer Research.

Related Links:
Washington University School of Medicine in St. Louis

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62 (732.8987121582): SELECT fid FROM jos_deeppockets WHERE id=283160000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=283160000 AND published='1' LIMIT 1

63 (281.81076049805): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

64 (!!!!! 2017.0211791992): select jos_twitters.link from jos_twitters where cat=10

65 (200.98686218262): select jos_facebook.link from jos_facebook where cat=10

66 (34.093856811523): select jos_google_plus.link from jos_google_plus where cat=10

67 (28.848648071289): select jos_linkedin.link from jos_linkedin where cat=10

68 (411.03363037109): SELECT fid FROM jos_deeppockets WHERE id=283160000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=283160000 AND published='1' LIMIT 1

69 (144.00482177734): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (!!!!! 1011.1331939697): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=283160000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (281.09550476074): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=283160000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (535.01129150391): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 3715.991973877): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (269.17457580566): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (771.99935913086): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (72.002410888672): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (164.98565673828): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (163.07830810547): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (128.03077697754): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (31.232833862305): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (133.03756713867): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 1008.0337524414): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=283160000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (36.001205444336): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=283160000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (164.98565673828): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (775.09880065918): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (339.98489379883): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (159.97886657715): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (!!!!! 2664.0892028809): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (241.04118347168): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (420.09353637695): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 4389.0476226807): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

105 (760.07843017578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

106 (80.108642578125): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=283160000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (525.95138549805): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=283160000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 4747.8675842285): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

109 (178.09867858887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

110 (140.19012451172): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=283160000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 4051.9237518311): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=283160000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 2217.0543670654): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 4492.0444488525): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 3386.9743347168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

115 (246.04797363281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

116 (!!!!! 1108.1695556641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

117 (112.05673217773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

118 (!!!!! 1142.0249938965): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

119 (185.01281738281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

120 (!!!!! 1496.0765838623): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

121 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

122 (324.96452331543): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 47341.108322144): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (771.99935913086): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=283160000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=283160000 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 19098.997116089): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (82.969665527344): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (77.009201049805): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (!!!!! 1286.9834899902): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (195.02639770508): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (315.90461730957): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (385.99967956543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 1329.1835784912): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (442.9817199707): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (41.961669921875): SELECT name FROM jos_deeppockets WHERE id=213

138 (30.040740966797): SELECT name FROM jos_deeppockets WHERE id=213

139 (568.86672973633): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (519.99092102051): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (165.93933105469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

142 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

143 (!!!!! 20854.949951172): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 5227.0889282227): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=283160000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (!!!!! 7015.9435272217): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=283160000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 10946.035385132): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (!!!!! 2038.9556884766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 3485.9180450439): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

149 (!!!!! 4685.8787536621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

150 (!!!!! 5564.9280548096): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (828.98139953613): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

152 (305.8910369873): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

153 (628.94821166992): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=283160000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=283160000 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (41.961669921875): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (!!!!! 3638.0290985107): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (!!!!! 7824.8977661133): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 8466.0053253174): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

158 (!!!!! 6966.1140441895): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=283160000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=283160000 AND published='1' LIMIT 1

159 (503.0632019043): select jos_twitters.link from jos_twitters where cat=10

160 (108.00361633301): select jos_facebook.link from jos_facebook where cat=10

161 (166.17774963379): select jos_google_plus.link from jos_google_plus where cat=10

162 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

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