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Combined PET/CT Scanning Beneficial for Lymphoma Patients

By MedImaging staff writers
Posted on 07 Apr 2008

Combined positron emission tomography (PET) and computed tomography (CT) imaging of lymphoma patients is a more effective method to evaluate the response to radiation therapy, and may help patients avoid unnecessary follow-up treatments, according to a recent study.

The findings of the study, performed by researchers at the University of Southern California (USC; Los Angeles), were published in the March 2008 issue of the journal Radiology. The clinical study is the first to show the advantage of combined PET-CT imaging in evaluating radioimmunotherapy for patients with non-Hodgkin lymphoma, according to Gary Ulaner, M.D., Ph.D., radiology resident, and nuclear medicine fellow at the USC Keck School of Medicine and the lead investigator of the study.

"Combined PET-CT imaging is more accurate in defining a complete response to radio-immunotherapy treatment,” remarked Dr. Ulaner. "Specifically, PET-CT is able to correctly label inactive scar masses, which are sometimes mistaken for active cancer when CT is used alone.”

Radioimmunotherapy is a type of radiation treatment that targets cancer cells through antibodies. The therapy causes less harm to healthy cells and typically results in fewer side effects than other cancer treatments, according to Dr. Ulaner. Usually, the treatment has been evaluated by use of CT imaging alone, which uses special X-ray equipment to produce multiple images of the inside of the body.

PET is a type of nuclear medicine imaging that uses very small amounts of radioactive material to diagnose or treat disease and other abnormalities. When PET and CT scans are combined, they can produce a more complete image of the cancer metabolism.

Researchers from the USC Positron Emission Tomography Center evaluated five men and five women ranging in age from 38 to 70 years who underwent PET and CT imaging, both several weeks before and several months after radioimmunotherapy for non-Hodgkin lymphoma. After evaluation of CT images alone, 8 of 10 patients were classified as responders to treatment, and 2 patients were classified as having a complete response to the treatment.

After reevaluating with the fused PET-CT scans, researchers found that two patients who had residual lesions had been misclassified. Both of the patients were free of evident disease, and remained healthy after 18 or more months of follow-up.

"Using this relatively novel hybrid imaging means that some patients will only require a one-day treatment of radioimmunotherapy instead of several rounds of chemotherapy,” stated Peter Conti, M.D, Ph.D., professor of radiology at the Keck School of Medicine. "We will have a more accurate image that will identify the patients who have a complete response to the treatment.”

Dr. Conti is a leading specialist in treatment of non-Hodgkin lymphoma with radioimmunotherapy. "We hope this research will result in PET-CT imaging becoming the standard for evaluating patients after treatment. Greater accuracy will improve how physicians care for lymphoma patients.”

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65 (97.036361694336): select jos_facebook.link from jos_facebook where cat=10

66 (46.968460083008): select jos_google_plus.link from jos_google_plus where cat=10

67 (43.153762817383): select jos_linkedin.link from jos_linkedin where cat=10

68 (55.074691772461): SELECT fid FROM jos_deeppockets WHERE id=277360000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=277360000 AND published='1' LIMIT 1

69 (46.968460083008): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (476.12190246582): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=277360000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (419.13986206055): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=277360000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (61.03515625): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (117.06352233887): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (77.009201049805): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=277360000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (41.961669921875): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=277360000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (47.922134399414): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

105 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

106 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=277360000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=277360000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

109 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

110 (45.7763671875): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=277360000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (557.89947509766): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=277360000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (593.18542480469): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (488.9965057373): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (108.95729064941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

115 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

116 (123.97766113281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

117 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

118 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

119 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

120 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

121 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

122 (380.03921508789): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 23450.136184692): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (519.0372467041): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=277360000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=277360000 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (66.995620727539): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (49.829483032227): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (80.82389831543): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (28.848648071289): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (565.0520324707): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (401.97372436523): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (44.107437133789): SELECT name FROM jos_deeppockets WHERE id=213

138 (30.994415283203): SELECT name FROM jos_deeppockets WHERE id=213

139 (555.03845214844): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (550.0316619873): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

142 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

143 (!!!!! 8800.0297546387): TRUNCATE TABLE jos_trademed_module

144 (112.05673217773): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=277360000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (61.988830566406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=277360000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (532.86552429199): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

149 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

150 (!!!!! 1330.8525085449): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

152 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

153 (50.783157348633): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=277360000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=277360000 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (38.14697265625): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (49.829483032227): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

158 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=277360000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=277360000 AND published='1' LIMIT 1

159 (46.968460083008): select jos_twitters.link from jos_twitters where cat=10

160 (32.901763916016): select jos_facebook.link from jos_facebook where cat=10

161 (32.901763916016): select jos_google_plus.link from jos_google_plus where cat=10

162 (40.054321289062): select jos_linkedin.link from jos_linkedin where cat=10

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