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Earlier Diagnosis of Dementia and Alzheimer's Disease from Targeted Imaging

By MedImaging staff writers
Posted on 31 Mar 2008

Researchers involved in a large, multi-institutional study utilizing positron emission tomography (PET) imaging with the radiotracer fluorodeoxyglucose (FDG) were able to classify different types of dementia with very high rates of success, raising hopes that dementia diagnoses may one day be made at earlier stages.

"Previously, scientists have been able to look only at the surface of the brain to differentiate various types of dementia,” said Lisa Mosconi, Ph.D., assistant professor of psychiatry at the New York University School of Medicine (New York, NY, USA). "With FDG PET, we were able to develop standardized disease-specific patterns from which we could correctly classify dementia more than 94% of the time.”

The study, which was reported in the March 2008 issue of the Journal of Nuclear Medicine, measured the cerebral metabolic rate of glucose (CMRglc)--the amount of sugar the brain uses to fuel its activities--in various areas of the organ. A decrease in this rate is indicative of a loss of nerve cells and of dysfunction associated with dementia. Because FDG behaves like glucose when injected into the body, its location in the PET scans pinpointed the specific area where glucose utilization had fallen below normal levels as compared to an age-appropriate control group.

"Each type of dementia examined--Alzheimer's disease (AD), frontotemporal dementia [FTD], and dementia with Lewy bodies (DLB)--affects a different area of the brain. Based on where in the brain this decrease occurred, we were able to determine which type of dementia a patient had,” Dr. Mosconi explained.

For instance, only AD patients have severe CMRglc reductions in the hippocampus (a part of the brain located deep in the organ and, prior to this study, unreachable for examination), whereas FTD patients have only mild abnormalities in the area and DLB patients have no hippocampal hypometabolism. "We believe that the ability to measure this embedded area in the brain will be important in identifying AD at an early stage,” added Dr. Mosconi.

This is also the first study to use FDG PET to compare an early stage of dementia known as mild cognitive impairment (MCI) with dementing diseases other than AD. According to the researchers, the findings suggest that the ability to detect differentiated uptake of glucose may result in earlier and more accurate diagnoses of MCI and better disease management.

"Because the incidence of these disorders is expected to increase dramatically as the baby-boomer generation ages, accurate diagnosis is extremely important--particularly at the early and mild stages of dementia when life-style changes and therapeutic interventions would be most effective,” said Dr. Mosconi.

The study comprised 548 individuals and it is the largest FDG PET study measuring brain metabolism in different dementing disorders to date. Researchers from PET centers in the United States and Europe were able to apply and share objective image analysis procedures easily, opening up the possibility that this diagnostic procedure could be adapted to a clinical setting.

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64 (429.86869812012): select jos_twitters.link from jos_twitters where cat=10

65 (32.901763916016): select jos_facebook.link from jos_facebook where cat=10

66 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

67 (29.802322387695): select jos_linkedin.link from jos_linkedin where cat=10

68 (279.90341186523): SELECT fid FROM jos_deeppockets WHERE id=276680000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=276680000 AND published='1' LIMIT 1

69 (!!!!! 1230.001449585): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (677.82402038574): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=276680000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (478.98292541504): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=276680000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (136.13700866699): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 1144.1707611084): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (840.90232849121): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (185.96649169922): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (504.0168762207): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (!!!!! 3365.9934997559): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (!!!!! 1450.0617980957): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (!!!!! 3669.9771881104): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (!!!!! 1303.9112091064): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (!!!!! 4081.9644927979): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (341.89224243164): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (!!!!! 4938.8408660889): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (!!!!! 6309.0324401855): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 4921.9131469727): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=276680000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (!!!!! 5110.9790802002): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=276680000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (!!!!! 1039.981842041): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 1168.0126190186): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (272.98927307129): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (946.044921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (308.03680419922): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (530.00450134277): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (481.84394836426): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (447.98851013184): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (!!!!! 5911.111831665): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (79.154968261719): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (490.90385437012): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (420.09353637695): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (390.05279541016): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (396.9669342041): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1908.0638885498): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

105 (388.14544677734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

106 (560.04524230957): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=276680000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (874.99618530273): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=276680000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 7443.904876709): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

109 (625.1335144043): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

110 (500.91743469238): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=276680000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 1122.9515075684): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=276680000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 2754.9266815186): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 4275.0835418701): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (128.03077697754): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

115 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

116 (49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

117 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

118 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

119 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

120 (892.16232299805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

121 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

122 (!!!!! 1301.0501861572): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 62068.939208984): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 1125.8125305176): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=276680000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=276680000 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (284.19494628906): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (61.988830566406): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (252.00843811035): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (53.167343139648): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (!!!!! 1051.9027709961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (67.949295043945): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (44.822692871094): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (43.869018554688): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (60.081481933594): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 1764.0590667725): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (425.10032653809): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (!!!!! 3453.0162811279): SELECT name FROM jos_deeppockets WHERE id=213

138 (102.99682617188): SELECT name FROM jos_deeppockets WHERE id=213

139 (!!!!! 3837.1086120605): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (!!!!! 1275.0625610352): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (343.79959106445): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

142 (252.00843811035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

143 (!!!!! 15480.041503906): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 10478.973388672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=276680000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (150.91896057129): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=276680000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 3322.8397369385): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (117.06352233887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

149 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

150 (!!!!! 2180.814743042): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 1793.8613891602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

152 (733.85238647461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

153 (41.007995605469): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=276680000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=276680000 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (32.186508178711): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (!!!!! 2503.1566619873): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (74.863433837891): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (89.168548583984): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

158 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=276680000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=276680000 AND published='1' LIMIT 1

159 (93.936920166016): select jos_twitters.link from jos_twitters where cat=10

160 (41.961669921875): select jos_facebook.link from jos_facebook where cat=10

161 (42.915344238281): select jos_google_plus.link from jos_google_plus where cat=10

162 (46.014785766602): select jos_linkedin.link from jos_linkedin where cat=10

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