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Improved Medical Imaging and Drug Development May Result from Reference Isotope

By MedImaging staff writers
Posted on 28 Jan 2008

An increasingly popular radioactive isotope now has its own reference stand-in. The isotope may ultimately improve medical imaging, speed up clinical trials of many drugs, and facilitate efforts to develop more individualized medical treatment.

The number of medical images obtained through the technique known as positron emission tomography (PET) imaging is increasing at a rate of 20% per year, and this has correspondingly increased the use of fluorine-18, the radioactive isotope of choice in the vast majority of PET procedures. Injected into the bloodstream while bound to "carrier” molecules, fluorine-18 lights up the body during PET scans to perform such tasks as revealing tumors, tracking heart activity, and determining which regions of the brain are active during specific tasks.

However, fluorine-18 has a very short life --a batch of the compound decays to half its initial quantity in fewer than two hours, and less than one ten-thousandth of the original amount is left after a single day. Because the isotope decays so rapidly, it is not possible for a single central lab to make precise measurements on fluorine-18 solutions and then distribute them to remote centers to calibrate PET machines. This lack of a "standard reference” for fluorine-18 means that PET-related measurements from center to center, from patient to patient, and even in the same patient over time, are difficult or impossible to compare with one another.

Researchers from the U.S. National Institute of Standards and Technology (NIST; Gaithersburg, MD, USA) collaborating with a nuclear medicine company called RadQual (Concord, NH, USA), have looked to germanium-68 as a calibration surrogate for fluorine-18. This germanium isotope is much longer lived--its half-life is 270.95 days--but its radiation decay characteristics are otherwise similar to fluorine-18. Small differences between measurements of germanium-68 and fluorine-18 can be accounted for through the use of mathematic conversion factors. Germanium-68 never would be used in actual PET procedures; it would only be used to calibrate the machines properly, enabling more accurate measurements of the fluorine-18 isotopes. Although germanium-68 has been used for performing corrections on PET scanners, the industry has lacked a traceable standard reference material for instrument calibration.

NIST researchers have calibrated solutions of germanium-68 that could become the basis of a new standard reference material for this isotope. The next phase of this project involves working with RadQual to calibrate a new "mock” syringe standard that would use germanium-68 embedded in an epoxy to simulate fluorine-18 in a syringe. This would help researchers more accurately determine the amount of fluorine-18 to be injected into patients during the PET procedure so as to minimize radiation dose while still generating the best image. NIST is also working independently on a germanium-68-based PET "phantom” that can be used to calibrate PET scanners in a way that is traceable back to NIST.

The first commercial products from this collaboration may be reaching PET centers later in 2008. By giving clinicians more effective results on how specific patients are responding to cancer treatments and providing more accurate indications earlier in clinical trials as to how individual patients are metabolizing specific drugs, better standards for PET imaging may hasten the arrival of customized medicine.

Related Links:
National Institute of Standards and Technology
RadQual

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63 (73.19450378418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

64 (83.92333984375): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

65 (595.8080291748): SELECT fid FROM jos_deeppockets WHERE id=269350000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=269350000 AND published='1' LIMIT 1

66 (65.088272094727): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

67 (56.028366088867): select jos_twitters.link from jos_twitters where cat=10

68 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

69 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

70 (29.802322387695): select jos_linkedin.link from jos_linkedin where cat=10

71 (32.186508178711): SELECT fid FROM jos_deeppockets WHERE id=269350000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=269350000 AND published='1' LIMIT 1

72 (30.994415283203): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

73 (361.91940307617): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=269350000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (267.02880859375): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=269350000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (46.968460083008): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

76 (53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (49.114227294922): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=269350000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (65.803527832031): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=269350000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (36.954879760742): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

93 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (126.83868408203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

108 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

109 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=269350000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=269350000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

112 (49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

113 (72.956085205078): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=269350000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (600.09956359863): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=269350000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (658.03527832031): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

116 (343.79959106445): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

118 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

119 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

120 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

121 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

122 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

123 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

124 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

125 (309.94415283203): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

126 (!!!!! 20710.945129395): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

127 (495.91064453125): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=269350000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=269350000 AND type='deeppockets_item' AND published='1' LIMIT 1

128 (53.167343139648): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

129 (36.001205444336): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

131 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

132 (48.160552978516): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

133 (28.848648071289): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

134 (32.186508178711): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

135 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

136 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

137 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

138 (515.93780517578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (432.01446533203): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (49.114227294922): SELECT name FROM jos_deeppockets WHERE id=213

141 (45.061111450195): SELECT name FROM jos_deeppockets WHERE id=213

142 (671.8635559082): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (658.98895263672): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

145 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

146 (!!!!! 8934.0209960938): TRUNCATE TABLE jos_trademed_module

147 (143.05114746094): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=269350000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=269350000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (952.00538635254): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

152 (65.803527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

153 (!!!!! 1208.0669403076): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

154 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

155 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

156 (59.843063354492): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=269350000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=269350000 AND type='deeppockets_item' AND published='1' LIMIT 1

157 (48.87580871582): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

158 (43.153762817383): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

159 (51.021575927734): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

160 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

161 (57.220458984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=269350000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=269350000 AND published='1' LIMIT 1

162 (47.206878662109): select jos_twitters.link from jos_twitters where cat=10

163 (31.948089599609): select jos_facebook.link from jos_facebook where cat=10

164 (41.007995605469): select jos_google_plus.link from jos_google_plus where cat=10

165 (33.140182495117): select jos_linkedin.link from jos_linkedin where cat=10

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