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Technique Enables More Effective PET Scanning to Detect Cancer, Heart Conditions
By MedImaging International staff writers Posted on 04 Nov 2014
A novel technique that reduces image degradation caused by respiratory motion during a positron emission tomography (PET) imaging scan was recently developed. The new technique is based on bioimpedance measurement, and it allows for image reconstruction at a specific phase of the patient’s breathing pattern. This, in turn, makes it possible to reduce image degradation caused by motion.
The new technique was presented in the PhD thesis of Tuomas Koivumäki, MSc (Tech), from the University of Eastern Finland (Joensuu, Finland), and is based on bioimpedance measurement. The strategy allows for image reconstruction at a specific phase of the patient’s breathing pattern. This, in turn, makes it possible to reduce image degradation caused by motion.
In the future, the newly developed technique will enable increasingly accurate image acquisition especially during PET scans performed to detect cancers of the chest and upper abdomen, and inflammatory disorders of the heart.
Due to enhanced image quality, PET images provide new and increasingly accurate data, potentially improving diagnosis effectiveness and treatment response monitoring. High-quality image data make the treatment more efficient, both medically and financially.
The study revealed that when synchronizing images on the basis of bioimpedance, it was possible to discern smaller details. Motion compensation also significantly influenced the parameters measured from the images. Bioimpedance measurement offers a straightforward technique for acquiring the data needed for motion compensation. Furthermore, the technique can be easily integrated into electrocardiogram (ECG) measurement, which is widely used to monitor heart function during the scan.
In techniques based on bioimpedance measurement, a very weak electrical current is passed through the patient's chest, and changes in the resulting voltage are measured. The voltage has been observed to change according to the patient’s breathing and cardiac function. Earlier, bioimpedance measurements have been used to assess, for example, body composition, fluid accumulations in lungs, and indicators of cardiac function.
The study focused on the feasibility of bioimpedance-based measurement techniques for respiratory and cardiac motion compensation in PET imaging. The study first used computational models and test subjects to determine an optimized bioimpedance measurement configuration for simultaneous measurement of respiratory and cardiac gating signals. The second phase of the study focused on analyzing whether bioimpedance techniques can be used to reduce respiration-related degradation of PET images.
PET scanning is used for cancer staging and evaluating treatment response, as well as for studying myocardial blood flow and inflammatory diseases of the heart. Typically, a PET scan takes several minutes, which is why movement caused by the patient’s breathing inevitably degrades image quality. Degraded image quality caused by respiratory motion has been reported to affect PET scanning performed to detect specifically cancer and heart conditions. At worst, image degradation may lead to a wrong diagnosis and inadequate or unnecessary treatment.
Related Links: University of Eastern Finland
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(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 190
(44.107437133789): SELECT fid FROM jos_deeppockets
WHERE cat=10
AND id=294755487
AND (type='deeppockets_item' OR type='deeppockets_item_link')
AND published='1'
LIMIT 191
(30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294755487 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 192
(34.093856811523): SELECT id,name,title
FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
AND id != 294743300
AND id != 294743301
AND id != 294743302
AND id != 294743303
AND id != 294743304
AND id != 294743305
AND id != 294743306
AND id != 294743307
AND id != 294743308
AND id != 294743309
AND id != 294743310
AND metakey != 'aacc'
ORDER BY `ordering`93
(43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 194
(30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 195
(61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 196
(60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 197
(32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 198
(35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 199
(46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1100
(29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1101
(38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1102
(35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1103
(36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1104
(35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1105
(36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1106
(35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1107
(103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1108
(146.86584472656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1109
(53.882598876953): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294755487
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1110
(48.87580871582): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294755487
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1111
(73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1112
(41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1113
(49.829483032227): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.id=294755487
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1114
(660.89630126953): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.id=294755487
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1115
(677.10876464844): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
LEFT JOIN jos_experts as ex
ON ex.id = dp.author
LEFT JOIN jos_deeppockets as dp2
ON dp2.id = dp.fid
WHERE dp.author != 0
AND dp.cat = 10
AND dp.published = 1
AND (
(dp.fid = 294743300)
OR (dp.fid = 294743301)
OR (dp.fid = 294743302)
OR (dp.fid = 294743303)
OR (dp.fid = 294743304)
OR (dp.fid = 294743305)
OR (dp.fid = 294743306)
OR (dp.fid = 294743307)
OR (dp.fid = 294743308)
OR (dp.fid = 294743309)
OR (dp.fid = 294743310)
)
ORDER BY RAND()
LIMIT 1116
(342.13066101074): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
LEFT JOIN jos_experts as ex
ON ex.id = dp.author
LEFT JOIN jos_deeppockets as dp2
ON dp2.id = dp.fid
WHERE dp.author != 0
AND dp.cat = 10
AND dp.published = 1
AND (
(dp.fid = 294743300)
OR (dp.fid = 294743301)
OR (dp.fid = 294743302)
OR (dp.fid = 294743303)
OR (dp.fid = 294743304)
OR (dp.fid = 294743305)
OR (dp.fid = 294743306)
OR (dp.fid = 294743307)
OR (dp.fid = 294743308)
OR (dp.fid = 294743309)
OR (dp.fid = 294743310)
)
ORDER BY RAND()
LIMIT 1117
(75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1118
(47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1119
(133.03756713867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1120
(91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1121
(47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1122
(39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1123
(54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1124
(37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1125
(283.00285339355): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`126
(!!!!! 22262.096405029): SELECT
*
FROM
jos_deeppockets
WHERE
jos_deeppockets.cat = 10
AND
jos_deeppockets.type = 'deeppockets_item'
AND
jos_deeppockets.published = 1
AND
jos_deeppockets.created + INTERVAL 14 DAY >= NOW()
ORDER BY
jos_deeppockets.hits DESC
LIMIT
7127
(518.0835723877): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294755487 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294755487 AND type='deeppockets_item' AND published='1' LIMIT 1128
(!!!!! 7835.1497650146): (
SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.video != ''
AND
dp.video_source != ''
AND
dp.cat = 10
AND
dp.published = 1
AND
dp.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
UNION
(
SELECT
dpa.id,
dpa.name,
dpa.title,
dpa.video,
dpa.video_source,
dpa.created
FROM
jos_deeppockets_archive AS dpa
WHERE
dpa.video != ''
AND
dpa.video_source != ''
AND
dpa.cat = 10
AND
dpa.published = 1
AND
dpa.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
ORDER BY
created DESC
LIMIT
3129
(92.983245849609): (
SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.video != ''
AND
dp.video_source != ''
AND
dp.cat = 10
AND
dp.published = 1
AND
dp.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
UNION
(
SELECT
dpa.id,
dpa.name,
dpa.title,
dpa.video,
dpa.video_source,
dpa.created
FROM
jos_deeppockets_archive AS dpa
WHERE
dpa.video != ''
AND
dpa.video_source != ''
AND
dpa.cat = 10
AND
dpa.published = 1
AND
dpa.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
ORDER BY
created DESC
LIMIT
3130
(77.962875366211): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294803337
LIMIT 1131
(42.915344238281): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294803337
LIMIT 1132
(67.949295043945): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294803276
LIMIT 1133
(30.040740966797): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294803276
LIMIT 1134
(298.02322387695): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets_archive AS dp
WHERE
dp.id = 294803276
LIMIT 1135
(33.140182495117): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets_archive AS dp
WHERE
dp.id = 294803276
LIMIT 1136
(30.994415283203): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294802958
LIMIT 1137
(28.133392333984): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294802958
LIMIT 1138
(433.92181396484): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294755487
AND (type='deeppockets_item' OR type='deeppockets_item_link')
AND published='1'
LIMIT 1139
(346.89903259277): SELECT *
FROM jos_deeppockets_archive
WHERE 1=1
AND id=294755487
AND (type='deeppockets_item' OR type='deeppockets_item_link')
AND published='1'
LIMIT 1140
(192.88063049316): SELECT name FROM jos_deeppockets WHERE id=213141
(31.948089599609): SELECT name FROM jos_deeppockets WHERE id=213142
(564.0983581543): SELECT *,
DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
FROM jos_events
WHERE state=1
AND publish_up > NOW()
and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110)
ORDER BY publish_up ASC LIMIT 3143
(491.85752868652): SELECT *,
DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
FROM jos_events
WHERE state=1
AND publish_up > NOW()
and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110)
ORDER BY publish_up ASC LIMIT 3144
(66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1145
(43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1146
(!!!!! 8394.9565887451): TRUNCATE TABLE jos_trademed_module147
(97.990036010742): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294755487
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1148
(80.82389831543): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294755487
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1149
(977.0393371582): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294755487
AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1150
(59.127807617188): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294755487
AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1151
(95.844268798828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1152
(82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1153
(!!!!! 1071.9299316406): SELECT jos_item.*
FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id
WHERE 1=1
AND (jos_item.imgMini<>'')
AND jos_item.type='L'
AND jos_item.numberID= (
SELECT jos_number.id
FROM jos_number
WHERE jos_number.journalID IN (10)
and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P')
ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC
LIMIT 0,1
)
ORDER BY RAND() DESC LIMIT 6154
(65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1155
(43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1156
(41.961669921875): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294755487 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294755487 AND type='deeppockets_item' AND published='1' LIMIT 1157
(408.88786315918): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=213 or channel_id is null)158
(36.954879760742): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=213 or channel_id is null)159
(31.948089599609): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1160
(66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1161
(46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294755487 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294755487 AND published='1'
LIMIT 1162
(35.04753112793): select jos_twitters.link from jos_twitters where cat=10163
(30.994415283203): select jos_facebook.link from jos_facebook where cat=10164
(29.802322387695): select jos_google_plus.link from jos_google_plus where cat=10165
(29.802322387695): select jos_linkedin.link from jos_linkedin where cat=10166
(255.10787963867): update jos_bannersmanager_banner
set impmade=impmade+1
where id in(14615,14202,14203)167
(!!!!! 1152.0385742188): insert into jos_banners_delta values (14615,'2025-09-27 04:16:54','216.73.216.151','view'),(14202,'2025-09-27 04:16:54','216.73.216.151','view'),(14203,'2025-09-27 04:16:54','216.73.216.151','view')
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