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27 Jul 2025 - 30 Jul 2025

AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Deep Learning Based Algorithms Improve Tumor Detection in PET/CT Scans

By MedImaging International staff writers
Posted on 03 Jan 2025

Image: Automated methods enable the analysis of PET/CT scans (left) to accurately predict tumor location and size (right) (Photo courtesy of Nature Machine Intelligence, 2024. DOI: 10.1038/s42256-024-00912-9)

Imaging techniques are essential for cancer diagnosis, as accurately determining the location, size, and type of tumors is critical for selecting the appropriate treatment. The key imaging methods include positron emission tomography (PET) and computed tomography (CT). PET utilizes radionuclides to visualize metabolic activity within the body, with malignant tumors exhibiting significantly higher metabolic rates than benign tissues. For this, fluorine-18-deoxyglucose (FDG), a radioactively labeled glucose, is commonly employed. In CT, the body is scanned layer by layer using an X-ray tube to visualize anatomical structures and pinpoint tumors. Cancer patients often present with numerous lesions—pathological changes resulting from tumor growth—and capturing all lesions for a comprehensive view is necessary. Typically, doctors manually mark tumor lesions on 2D slice images, a process that is very time-consuming. An automated algorithm for evaluation could drastically reduce time and enhance diagnostic accuracy.

In 2022, researchers from the Karlsruhe Institute of Technology (KIT, Karlsruhe, Germany) participated in the international autoPET competition and placed fifth out of 27 teams, comprising 359 participants globally. autoPET combined imaging with machine learning to automate the segmentation of metabolically active tumor lesions visible on whole-body PET/CT scans. Teams had access to a large, annotated PET/CT dataset to train their algorithms. All final submissions relied on deep learning, a type of machine learning using multi-layered artificial neural networks to identify complex patterns and correlations in large datasets. The seven leading teams from the competition recently shared their findings in the journal Nature Machine Intelligence, highlighting the potential of automated analysis in medical imaging.

The researchers found that an ensemble of the best-performing algorithms outperformed individual models. This ensemble approach allowed for more efficient and accurate detection of tumor lesions. While the algorithm's performance is influenced by the quality and quantity of data, the design of the algorithm, particularly decisions made in post-processing the predicted segmentations, also plays a critical role. The researchers noted that further improvements are needed to enhance the algorithms’ resilience to external factors, with the goal of making them suitable for routine clinical use. The ultimate aim is to fully automate the analysis of PET and CT medical image data in the near future.

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87 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

91 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

92 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803607 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

93 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

94 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

95 (344.03800964355): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294803607 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (738.14392089844): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

97 (531.19659423828): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

98 (241.99485778809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

99 (127.07710266113): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

100 (205.99365234375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

101 (168.0850982666): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

102 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

103 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

104 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

105 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

106 (308.03680419922): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

107 (!!!!! 52875.04196167): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

108 (914.09683227539): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294803607 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294803607 AND type='deeppockets_item' AND published='1' LIMIT 1

109 (80.108642578125): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

110 (53.882598876953): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

111 (295.16220092773): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

112 (33.140182495117): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

113 (56.982040405273): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

114 (232.93495178223): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

115 (241.99485778809): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

116 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

117 (44.107437133789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

118 (31.232833862305): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

119 (436.06758117676): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

120 (235.08071899414): SELECT name FROM jos_deeppockets WHERE id=215

121 (34.093856811523): SELECT name FROM jos_deeppockets WHERE id=215

122 (535.96496582031): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

123 (518.0835723877): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

124 (176.19132995605): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

125 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

126 (!!!!! 11725.187301636): TRUNCATE TABLE jos_trademed_module

127 (106.8115234375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803607 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

128 (844.00177001953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

129 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

130 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

131 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

132 (!!!!! 1155.8532714844): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

133 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

134 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

135 (36.001205444336): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294803607 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294803607 AND type='deeppockets_item' AND published='1' LIMIT 1

136 (33.140182495117): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

137 (32.186508178711): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

138 (34.093856811523): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

139 (128.03077697754): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

140 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803607 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803607 AND published='1' LIMIT 1

141 (45.7763671875): select jos_twitters.link from jos_twitters where cat=10

142 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

143 (29.802322387695): select jos_google_plus.link from jos_google_plus where cat=10

144 (27.894973754883): select jos_linkedin.link from jos_linkedin where cat=10

145 (299.93057250977): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

146 (920.05729675293): insert into jos_banners_delta values (14202,'2025-06-21 02:48:12','216.73.216.120','view'),(14203,'2025-06-21 02:48:12','216.73.216.120','view')

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