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AI Analysis of PET/CT Images Predicts Side Effects of Immunotherapy in Lung Cancer

By MedImaging International staff writers
Posted on 18 Nov 2024

Immunotherapy has significantly advanced the treatment of primary lung cancer, but it can sometimes lead to a severe side effect known as interstitial lung disease. More...

This condition is characterized by lung scarring (fibrosis) and can be life-threatening due to respiratory failure. Predicting the onset of interstitial lung disease caused by immunotherapy remains a challenge. As a result, there is a need for reliable methods to assess the risk of developing this condition following immunotherapy. Now, a new study has found that PET/CT image analysis combined with artificial intelligence (AI) can predict the likelihood of developing interstitial lung disease.

In this retrospective study, researchers from Niigata University (Niigata, Japan) analyzed data from 165 patients with primary lung cancer who were undergoing immunotherapy. It is generally believed that interstitial lung disease might develop when inflammation triggered by immunotherapy affects healthy lung tissue in addition to cancer cells. Based on this, the researchers hypothesized that patients with significant inflammation in their healthy lungs prior to treatment might be at greater risk of developing interstitial lung disease.

To test this hypothesis, the researchers utilized PET/CT scans, a nuclear imaging technique that can detect inflammation throughout the body. They used AI to assess the level of inflammation in noncancerous regions of the lungs—areas not affected by the cancer. The study, published in Academic Radiology, found that patients with high levels of inflammation in the healthy lung tissue were about 6.5 times more likely to develop interstitial lung disease after immunotherapy compared to those with lower inflammation.

"PET/CT is generally performed to detect cancer metastasis, but it would potentially be useful for estimating the risks of side effects associated with cancer treatment,” said researcher Motohiko Yamazaki. “The results of our study may not only help to predict the occurrence of interstitial lung disease after immunotherapy, but also to elucidate the mechanism of this serious side effect. We should conduct a multicenter prospective study for further investigation."

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81 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

94 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

95 (83.92333984375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803163 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

96 (104.90417480469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

97 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

98 (537.87231445312): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294803163 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

99 (420.09353637695): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294803157 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

100 (761.98577880859): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

101 (565.0520324707): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

102 (116.10984802246): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

103 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

104 (75.817108154297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

105 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

106 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

107 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

108 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

109 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

110 (826.12037658691): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

111 (!!!!! 29885.053634644): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

112 (571.96617126465): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294803163 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294803163 AND type='deeppockets_item' AND published='1' LIMIT 1

113 (!!!!! 10353.088378906): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

114 (106.0962677002): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

115 (307.08312988281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

116 (65.088272094727): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

117 (220.06034851074): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

118 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

119 (39.815902709961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

120 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

121 (182.8670501709): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

122 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

123 (353.09791564941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

124 (257.96890258789): SELECT name FROM jos_deeppockets WHERE id=215

125 (87.02278137207): SELECT name FROM jos_deeppockets WHERE id=215

126 (753.16429138184): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

127 (661.84997558594): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

128 (100.85105895996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

129 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

130 (!!!!! 10664.939880371): TRUNCATE TABLE jos_trademed_module

131 (163.07830810547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294803163 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

132 (653.98216247559): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

133 (106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (689.98336791992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

135 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

136 (!!!!! 3920.0782775879): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

137 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

138 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

139 (59.127807617188): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294803163 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294803163 AND type='deeppockets_item' AND published='1' LIMIT 1

140 (45.061111450195): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

141 (41.007995605469): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

142 (58.889389038086): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

143 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

144 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294803163 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294803163 AND published='1' LIMIT 1

145 (192.16537475586): select jos_twitters.link from jos_twitters where cat=10

146 (45.061111450195): select jos_facebook.link from jos_facebook where cat=10

147 (40.054321289062): select jos_google_plus.link from jos_google_plus where cat=10

148 (37.193298339844): select jos_linkedin.link from jos_linkedin where cat=10

149 (405.07316589355): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

150 (!!!!! 1446.9623565674): insert into jos_banners_delta values (14202,'2025-08-01 22:34:23','216.73.216.210','view'),(14203,'2025-08-01 22:34:23','216.73.216.210','view')

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